Bimodal effect of humic acids on the LPS-induced TNF-α release from differentiated U937 cells

Junek, Ralf; Morrow, R.; Schoenherr, J. I.; Schubert, Roland; Kallmeyer, R.; Phull, S.S.; Klöcking, R.

doi:10.1016/j.phymed.2008.10.003

Cited by 48 publications

(35 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Humic substances were found to exhibit many biological activities such as anti-inflammatory and pro-inflammatory properties31. K-humates isolated from oxihumolites could alleviate tobacco mosaic virus infection32 and humic acids from brown coals displayed biostimulation activity33.…”

Section: Discussionmentioning

confidence: 99%

Fungicidal activities of soil humic/fulvic acids as related to their chemical structures in greenhouse vegetable fields with cultivation chronosequence

Song

Liu

et al. 2016

Sci Rep

View full text Add to dashboard Cite

In the background of rapid expansion of plastic greenhouse vegetable production in China, many environmental risks have emerged in recent years. In this study, the soils with a chronosequence in greenhouse vegetable fields were collected and the soil humic acids (HAs) and fluvic acids (FAs) were extracted and purified. The soil HAs and FAs were found to show inhibition activities against phytopathogenic fungi for the first time. Fourier transform infrared spectroscopy was performed to investigate the chemical structures of HAs and FAs. The variation of relative peak areas indicated the chemical structure of HAs become more complex and stable under continuous cultivation. The PCA analysis showed HAs and FAs could be distinctly separated from each other and cultivation years mainly determined the variation. Mantel test and RDA analysis indicated the active components (aliphatic peaks for HAs and COOH, OH peaks for FAs) had positive correlation with the inhibition rates of HAs and FAs against phytopathogenic fungi. According to our research, the active fungicidal components in soil HAs and FAs decreased along with the extension of cultivation years, which made the soil suffer more risk to phytopathogenic fugi. So we believe continuous cultivation too many years in PGVP systems is inadvisable.

show abstract

Section: Discussionmentioning

confidence: 99%

Fungicidal activities of soil humic/fulvic acids as related to their chemical structures in greenhouse vegetable fields with cultivation chronosequence

Song

Liu

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…On the other hand, Chen et al () indicated that humic acid treatment increased the adhesion as well as the production of oxidants by stimulated neutrophils in vitro . Humic substances have also been reported to stimulate the release of pro‐inflammatory cytokines such as TNF‐alpha in vitro , but only in the presence of exogenous lipopolysaccharides (Junec et al, ), indicating that these substances should not cause inflammation under normal conditions.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

The Antiinflammatory Properties of Humic Substances: A Mini Review

Rensburg

2015

Phytotherapy Research

106

View full text Add to dashboard Cite

Humic substances are effective in the suppression of delayed type hypersensitivity, rat paw oedema, a graft-vs-host reaction and contact hypersensitivity in rats. They reduce the CRP (C reactive protein) levels of patients suffering from osteoarthritis of the knee and the wheel and flare reaction of patients suffering from hay fever. They have also been described as cardio protective and pro-angiogenic. Toxicity studies have indicated that potassium humate is safe in humans up to a daily dosage of 1g/kg, whereas fulvic acid is safe in humans up to a daily dosage of 1.8 g per adult. The anti-inflammatory action of potassium humate can be contributed to the inhibition of the release of inflammatory-related cytokines, an adhesion molecule, oxidants and components of the complement system.

show abstract

“…Research on the effect of the humic extract on the immune system, in vitro assay showed increased production of several cytokines (Joone et al, 2003;Junek et al, 2009) and improved the adhesion of neutrophils (Chen et al, 2003). Effect of humic acid from peat Kalimantan through supplementation in fish feed has been done by Rousdy (2013) showed an increase in the total antibody, total leukocyte count and phagocytic activity.…”

Section: Introductionmentioning

confidence: 99%

Immune Responses of Wistar Rat (Rattus novergicus) on Adduction of Humid Acid from Borneo Peat Soil

2016

View full text Add to dashboard Cite

Peat soil is a type of soil that dominates the island of Borneo. Typical compounds in peat soil is humic acid. Various in vitro studies performed have shown peat subtropical humic compounds can stimulate the immune system. However, in vivo study on animal has not been done. This study aimed to determine the effect of humic acid extracted from peat soil of Borneo against the immune system, both of non-specific and specific immunity Wistar rats (Rattus novergicus). Research using a completely randomized design with five treatments and five replicates, the normal controls, a positive control (isoprinosine), humic acid 125; 250; 500 mg/kg. Humic acid was administered orally for 10 days. The results showed humic acid adduction did not significantly affect levels of hemoglobin, erythrocytes and hematocrit. Humic acid adduction of 125 mg/kg significantly affects the total leukocyte count and differential leukocyte. Humic acid 125 mg/kg also showed increased phagocytic index better than normal controls. All humic acid treatments do not provide a significant effect on the total amount of antibody. The results of this study can be used for the development of Borneo tropical peat resources as natural imunostimulant.

show abstract

Bimodal effect of humic acids on the LPS-induced TNF-α release from differentiated U937 cells

Cited by 48 publications

References 17 publications

Fungicidal activities of soil humic/fulvic acids as related to their chemical structures in greenhouse vegetable fields with cultivation chronosequence

Fungicidal activities of soil humic/fulvic acids as related to their chemical structures in greenhouse vegetable fields with cultivation chronosequence

The Antiinflammatory Properties of Humic Substances: A Mini Review

Immune Responses of Wistar Rat (Rattus novergicus) on Adduction of Humid Acid from Borneo Peat Soil

Contact Info

Product

Resources

About