Binding Efficiency and Transport Properties of Molecularly Imprinted Polymer Thin Films

Abstract

A model system for the characterization of molecular recognition events in molecularly imprinted polymers (MIPs) is presented. The use of a biologically inspired, three-point hydrogen-bonding motif and a thin film polymeric matrix allows for pre- and post-polymerization binding properties to be characterized by infrared spectroscopy. A method to determine binding constants was developed and utilized before and after cross-linking. These values showed a 10-fold decrease in binding after polymerization, which was attributed to an increase in molecular confinement after polymerization and a change in the local structural environment of the binding cavity. Transport of the guest molecule was shown to be reversible.

A Kinetic Consideration on the Selective Adsorption and Molecular Recognition by Molecularly Imprinted Polymer

“…In basic condition, as already displayed, 23,24 the absorption band ranged from 3200 to 3600 cm −1 can be related to the stretching of amido.…”

Tuning the hydrogen-bonding strength in 2,6-bis(cycloalkylcarbonylamino)pyridine assemblies by variable flexibility. Association constants measured by hydrogen-bonded vs. non-hydrogen-bonded protons

“…Triple hydrogen-bonded associates are met in many structures as in DNA [14,15], amides [16,17], artificial sensors [18][19][20][21][22], materials [23], non-covalent polymers [4,[24][25][26][27][28] and in recently observed associates of orotic acid [29,30]. Triple hydrogen-bonded assemblies carrying 2,6-diaminopyridine DAD-hydrogen bonding moiety were studied by some groups with the use of various methods [4,6,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] and also by us [48,49]. We noticed that the use of NH and CH proton shifts as probes in Previously [48] we confirmed results from other group [50] reporting that the 2,6-bis(acylamino)pyridine do not dimerize.…”

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

“…580,581 Planar films and grafts. Planar MIP structures such as films and membranes have been prepared either by polymerization within a mould 820,821 or on a planar surface layer. 822,823 Grafting approaches have also been applied 824 and elctropolymerization has also been used to build up layers of acrylamide-based MIPs on ISFETs (ion-sensitive field effect transistors).…”