2015
DOI: 10.1093/molehr/gav051
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Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells

Abstract: Human parturition is associated with many pro-inflammatory mediators which are regulated by the nuclear factor-kappaB (NF-κB) family of transcription factors. In the present study, we employed a ChIP-on-chip approach to define genomic loci within chromatin of PHM1-31 myometrial cells that were occupied by RelA-containing NF-κB dimers in response to a TNF stimulation of 1 h. In TNF-stimulated PHM1-31 cells, anti-RelA serum enriched 13 300 chromatin regions; importantly, 11 110 regions were also enriched by anti… Show more

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“…We also found extracellular secretion of ET-1 was regulated by NF-kappaB (Figure 7B). The analysis of EDN1 showed it was at position 2055 bp upstream of the TSS, which contained RelA/p65 binding loci GGGCATTTCC [21]. Bioinformatics software JASPAR (http://jaspar.genereg.net) analyzed the promoter of EDN1 and found the binding loci of RelA gained the highest score.…”
Section: Resultsmentioning
confidence: 99%
“…We also found extracellular secretion of ET-1 was regulated by NF-kappaB (Figure 7B). The analysis of EDN1 showed it was at position 2055 bp upstream of the TSS, which contained RelA/p65 binding loci GGGCATTTCC [21]. Bioinformatics software JASPAR (http://jaspar.genereg.net) analyzed the promoter of EDN1 and found the binding loci of RelA gained the highest score.…”
Section: Resultsmentioning
confidence: 99%