Binding, Metabolism, and Action of Steroid Hormones in the Central Nervous System

Theoretical considerations of the differentiation of sexual behavior: Evidence from animal experiments

“…2) atL2mpts were made to relate this behavioral sex difference to receptor mechanisms of estrogen action in the brain. However, although some of the early evidence suggested reduced uptake of estrogen by the male rat brain compared to the female brain (Zigmond, 1975), most studies have shown a basic similarity in neural uptake and retention of estrogen by the brains of female and male rats (McEwen, 1976;Plapinger & McEwen, 1978). These findings are not surprising in view of the growing evidence that estrogen probably plays a physiological role in the control by T of the sexual behavior of male rats (Sodersten, 1979).…”