Binding of aluminium/cacodylate complexes with DNA and RNA. Experimental and “<i>in silico</i>”study

Lozano, Héctor; Busto, Natalia; Lari, M Amin; Leal, José M.; Garcı́a, Begoña

doi:10.1039/c8nj01779d

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…However, such technology has not yet been extended to NA capture. There is a range of common compounds with promising properties for NA adsorption from ambient water, including clay minerals, silica, and alumina [91,[169][170][171][172], as well as less conventional substrates that show potential for NA binding, e.g., functionalized graphene, gold nanoparticles, polyamidoamines [165,173,174]. The use of marine invertebrates, such as sponges [175], as natural samplers and bioaccumulators, is also an area of promise for ongoing, low-cost, surveillance, and is worthy of being explored further.…”

Section: Discussionmentioning

confidence: 99%

Towards the Optimization of eDNA/eRNA Sampling Technologies for Marine Biosecurity Surveillance

Bowers

Pochon

Ammon

et al. 2021

Water

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The field of eDNA is growing exponentially in response to the need for detecting rare and invasive species for management and conservation decisions. Developing technologies and standard protocols within the biosecurity sector must address myriad challenges associated with marine environments, including salinity, temperature, advective and deposition processes, hydrochemistry and pH, and contaminating agents. These approaches must also provide a robust framework that meets the need for biosecurity management decisions regarding threats to human health, environmental resources, and economic interests, especially in areas with limited clean-laboratory resources and experienced personnel. This contribution aims to facilitate dialogue and innovation within this sector by reviewing current approaches for sample collection, post-sampling capture and concentration of eDNA, preservation, and extraction, all through a biosecurity monitoring lens.

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Section: Discussionmentioning

confidence: 99%

Towards the Optimization of eDNA/eRNA Sampling Technologies for Marine Biosecurity Surveillance

Bowers

Pochon

Ammon

et al. 2021

Water

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Vanillin allied 1,2,3- triazole as a selective sensor for detection of Al3+ ions: A potent inhibitor against Entamoeba histolytica

Singh

Gupta²,

Diksha³

et al. 2023

Journal of Molecular Structure

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Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study

Türkez

Yıldırım

Şahin

et al. 2022

Toxics

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Genetic, neuropathological and biochemical investigations have revealed meaningful relationships between aluminum (Al) exposure and neurotoxic and hematotoxic damage. Hence, intensive efforts are being made to minimize the harmful effects of Al. Moreover, boron compounds are used in a broad mix of industries, from cosmetics and pharmaceuticals to agriculture. They affect critical biological functions in cellular events and enzymatic reactions, as well as endocrinal and mineral metabolisms. There are limited dose-related data about boric acid (BA) and other boron compounds, including colemanite (Col), ulexite (UX) and borax (BX), which have commercial prominence. In this study, we evaluate boron compounds’ genetic, cytological, biochemical and pathological effects against aluminum chloride (AlCl3)-induced hematotoxicity and neurotoxicity on different cell and animal model systems. First, we perform genotoxicity studies on in vivo rat bone marrow cells and peripheric human blood cultures. To analyze DNA and chromosome damage, we use single cell gel electrophoresis (SCGE or comet assay) and micronucleus (MN) and chromosome aberration (CA) assays. The nuclear division index (NDI) is used to monitor cytostasis. Second, we examine the biochemical parameters (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), total antioxidant capacity (TAC) and total oxidative status (TOS)) to determine oxidative changes in blood and brain. Next, we assess the histopathological alterations by using light and electron microscopes. Our results show that Al increases oxidative stress and genetic damage in blood and brain in vivo and in vitro studies. Al also led to severe histopathological and ultrastructural alterations in the brain. However, the boron compounds alone did not cause adverse changes based on the above-studied parameters. Moreover, these compounds exhibit different levels of beneficial effects by removing the harmful impact of Al. The antioxidant, antigenotoxic and cytoprotective effects of boron compounds against Al-induced damage indicate that boron may have a high potential for use in medical purposes in humans. In conclusion, our analysis suggests that boron compounds (especially BA, BX and UX) can be administered to subjects to prevent neurodegenerative and hematological disorders at determined doses.

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Binding of aluminium/cacodylate complexes with DNA and RNA. Experimental and “in silico”study

Abstract: Mechanism of the interaction of a dinuclear aluminium/cacodylate complex with nucleic acids.

Cited by 3 publications

References 30 publications

Towards the Optimization of eDNA/eRNA Sampling Technologies for Marine Biosecurity Surveillance

Towards the Optimization of eDNA/eRNA Sampling Technologies for Marine Biosecurity Surveillance

Vanillin allied 1,2,3- triazole as a selective sensor for detection of Al3+ ions: A potent inhibitor against Entamoeba histolytica

Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study

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