Binding of reactive organophosphate by oximes via hydrogen bond

Pappalardo, Andrea; Amato, Maria E.; Ballistreri, Francesco P.; Fragola, Valentina La Paglia; Tomaselli, Gaetano A.; Toscano, Rosa Maria; Sfrazzetto, Giuseppe Trusso

doi:10.1007/s12039-013-0463-1

Cited by 17 publications

(17 citation statements)

References 35 publications

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“…Our research group studied three different oximes (Figure 5A) having the ability to interact with DMMP in solution through the formation of hydrogen bond [50] . This ability was investigated by NMR and UV‐Vis spectroscopy.…”

Section: Sensing By Supramolecular Approachmentioning

confidence: 99%

Supramolecular Sensing of Chemical Warfare Agents

et al. 2021

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Chemical warfare agents are a class of organic molecules used as chemical weapons due to their high toxicity and lethal effects. For this reason, the fast detection of these compounds in the environment is crucial. Traditional detection methods are based on instrumental techniques, such as mass spectrometry or HPLC, however the use of molecular sensors able to change a detectable property (e. g., luminescence, color, electrical resistance) can be cheaper and faster. Today, molecular sensing of chemical warfare agents is mainly based on the “covalent approach”, in which the sensor reacts with the analyte, or on the “supramolecular approach”, which involves the formation of non‐covalent interactions between the sensor and the analyte. This Review is focused on the recent developments of supramolecular sensors of organophosphorus chemical warfare agents (from 2013). In particular, supramolecular sensors are classified by function of the sensing mechanism: i) Lewis Acids, ii) hydrogen bonds, iii) macrocyclic hosts, iv) multi‐topic sensors, v) nanosensors. It is shown how the supramolecular non‐covalent approach leads to a reversible sensing and higher selectivity towards the selected analyte respect to other interfering molecules.

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Section: Sensing By Supramolecular Approachmentioning

confidence: 99%

Supramolecular Sensing of Chemical Warfare Agents

et al. 2021

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“…For example, DMMP contains phosphoryl (P=O) groups, that give stronger hydrogen bonds to any available surface. (91) On the GO surface, oxygen functional and modified functional groups are available to form hydrogen bonds with DMMP. A study of the chemical interaction of DMMP and a self-assembled interface by Bertilsson et al showed that an acid surface (−COOH) has the strongest DMMP adsorption.…”

Section: Detection Of Chemical Warfare Agent Simulantmentioning

confidence: 99%

Graphene-based Materials in Gas Sensor Applications: A Review

Demon¹,

Kamisan²,

Abdullah³

et al. 2020

Sensors and Materials

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Graphene and chemically modified graphene can be fabricated via numerous routes each with its own merits concerning ease of processability, cost-effectiveness for large-scale production, and also health and safety. One of the promising applications of graphene-based composites is gas sensing, which is mainly useful for environmental monitoring. We review some of the significant findings on graphene-based sensing materials for the detection of organic vapors, toxic gases, and chemical warfare agent simulants using an electrochemical method. Electrochemical sensing can be performed by inducing interactions between gas molecules and a graphene layer, such as charge transfer that gives a change in an electrical signal. The intrinsic properties of graphene and its role in some gas sensing applications will be discussed. Graphene and graphene oxide (GO) work as continuous conductive networks with a large number of surface adsorption sites for many gas molecules. Hybrid graphene devices incorporate semiconductors, metals, and molecular binders to enhance the capabilities of solidstate gas sensors. This article also addresses current approaches to the commercialization of graphene-based gas sensors.

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“…Reactions of oximates with OP CWAs and their simulants are well-known, 8,24–27 and the parent oxime (4-nitrobenzaldoxime) is known to react with DCP and undergo a Beckman rearrangement to yield 4-nitrobenzonitrile. Confirmation of the reaction of 6 with DCP, and potentially DMMP, was sought in DMSO- d 6 in the presence of 5 , which does not form an organogel and thus removes additional complexities of studying reactions within organogel substrates.…”

Section: Synthesismentioning

confidence: 99%