Binding of Tetracycline to Mammalian Spermatozoa

Ericsson, R. J.; Baker, V. F.

doi:10.1038/214403a0

Cited by 51 publications

(5 citation statements)

References 5 publications

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“…Tetracyclines have been shown to bind to mature spermatozoa and interfere with sperm motility [25] and, therefore, should be avoided in men with a motility defect. Gentamicin and neomycin can decrease spermatogenesis, although they do not show an effect on mature spermatozoa in vitro.…”

Section: Medicationsmentioning

confidence: 99%

Preventable causes of male infertility

Thompson

1993

World J Urol

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The initial evaluation of the infertile man includes a diligent search for testicular factors, gonadotoxins, and coital factors so as to identify existing causes of impaired fertility and to prevent further dimunition in fertility. There are also prophylactic measures in the treatment of all men that can prevent future infertility, such as prompt correction of cryptorchidism, testicular torsion, genital infection, and adolescent varicocele and proper precautions to limit occupational, medical, and recreational gonadotoxins.

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Section: Medicationsmentioning

confidence: 99%

Preventable causes of male infertility

Thompson

1993

World J Urol

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“…In addition, this drug is a fluorophore: it binds avidly to human sperm. This connection may actually present a physical obstruction to motility (Ericsson and Baker, 1967). Other studies have also shown that the therapeutic dose of tetracycline induces a toxic sperm and testicular effect in male rats by induction of oxidative stress (Farombi et al, 2008).…”

Section: Discussionmentioning

confidence: 95%

Study of antibiotics and symbiotic effects on sperm quality using the CASA system

Bouchicha

Kalem

Mimoune³

et al. 2021

Vet. stn. (Online)

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The objective of the current work was to study in vitro sperm quality after antibiotics and symbiotic administration and to evaluate treatment administered before insemination with the aim of reducing artificial insemination failures in goats. This experimental study was carried out at the Animal Reproduction Biotechnology Laboratory (Blida, Algeria). Semen analysis was performed using the Computer-assisted sperm analysis system. In the first experimental approach, we used the antibiotics most commonly administered in the veterinary field for the treatment of subclinical endometritis. A total of eight antibiotics were studied. Each antibiotic tested was co-incubated with frozen goat semen brought from the Centre for Artificial Insemination and Genetic Improvement. For the second experimental approach, we incubated semen with a symbiotic (Symbiovéba). Finally, we selected two antibiotics among those used, namely colistin and cotrimoxazole, and these were co-incubated with the symbiotic and the semen, to examine possible combinations of antibiotics with symbiotics in the treatment and prevention of uterine infections (broad spectrum synergistic activity). Antibiotics have been shown to have a detrimental effect on the sperm cell, by decreasing sperm motility. The average value calculated on all antibiotics was 18% (as opposed to initial motility of 78% in the control group), with an alteration of the linear speed that would have a negative impact on fertilization. On the other hand, symbiotics had a beneficial effect on spermatozoa motility and vitality. The combination of the symbiotic and colistin proved to be very promising. In conclusion, the use of symbiotics in the treatment of subclinical endometriosis at the time of goat insemination is beneficial, and requires greater attention in future research.

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“…Evidence for such a mechanism has been based on chemical adsorption to the sperm cell, and we will discuss each of the chemical adsorption studies. Ericsson and Baker (1967) exposed rabbit, boar, and human sperm in vitro to tetracycline. Using fluorescence under ultraviolet and ultraviolet blue light as a marker of the presence of tetracycline, they determined that sperm heads and tails bound tetracycline and that qualitatively the fluorescence was retained after sperm washing.…”

Section: Chemicals Bound To Spermmentioning

confidence: 99%

The transport of chemicals in semen

Klemmt

Scialli²

2005

Birth Defects Research Pt B

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Three mechanisms have been proposed for exposure of the conceptus to chemicals in semen: access of chemicals to the maternal circulation after absorption from the vagina, direct chemical exposure of the conceptus following transport from the vagina to the uterine cavity, and delivery to the egg and subsequent conceptus of chemical bound to the sperm cell. We review published data for each of these three mechanisms. Human seminal fluid chemical concentrations are typically similar to or lower than blood concentrations, although some antimicrobial agents achieve higher concentrations in semen than in blood. Vaginal absorption of medications has been shown to occur, although the vehicles in which these medications are delivered to the vagina may maintain contact with the vaginal epithelium to a greater extent than does semen. Assuming total absorption of a seminal dose of a chemical with a high semen:blood concentration ratio, distribution within the recipient woman would result in a blood concentration at least three orders of magnitude lower than that in the man. Direct delivery of seminal chemicals into the uterine cavity of humans has not been shown to occur, although it may occur in species such as the rat in which seminal fluid has access to the uterine cavity. Chemicals in or on human sperm cells have been demonstrated with respect to tetracycline and cocaine in vitro and aluminum, lead, and cadmium in vivo. The in vitro cocaine study offers sufficiently quantitative data with which to predict that oocyte concentrations would be five orders of magnitude lower than blood concentrations associated with cocaine abuse, assuming a maximally cocaine-bound sperm were capable of fertilizing. Thus, even using liberal assumptions about transmission of chemicals in semen or sperm, predicted exposure levels of a pregnant woman or of the conceptus are three or more orders of magnitude lower than blood concentrations in the man whose semen is the putative vehicle for chemical transport.

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Binding of Tetracycline to Mammalian Spermatozoa

Cited by 51 publications

References 5 publications

Preventable causes of male infertility

Preventable causes of male infertility

Study of antibiotics and symbiotic effects on sperm quality using the CASA system

The transport of chemicals in semen

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