Binge-type eating attenuates corticosterone and hypophagic responses to restraint stress

Kinzig, Kimberly P.; Hargrave, Sara L.; Honors, Mary Ann

doi:10.1016/j.physbeh.2008.04.026

Cited by 69 publications

(76 citation statements)

References 36 publications

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“…The effects of constant or intermittent feeding of sucrose and/or lard on the anorectic stress effect, on the response of the HPA axis to stress, and on the stress-induced induction of expression of c-fos mRNA have been addressed in a number of studies (11,26,48,50,62,91). However, to our knowledge, the modulation of stress-induced c-fos mRNA expression in the rat model resistant to stress-induced anorexia has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

“…25,43,76). A number of studies have demonstrated that the option to consume palatable sucrose and/or lard can attenuate this "classical" stress-induced activation of the HPA axis with a lower induction of expression of CRF mRNA at the hypothalamic level and a blunted rise in plasma adrenocorticotropic hormone and corticosterone at the peripheral level (27,34,48,49,62,91).The central component of the HPA axis is not the sole neuronal target of palatable food. Indeed, rats with recurrent limited access to sucrose, without food restriction or in combination with food restriction, can develop some behavioral and physiological characteristics, such as stress-induced binging and cross-sensitization to amphetamine and alcohol, which allowed consideration of these models as sugar "dependency" and a "natural form of addiction" (6,7,20,21).…”

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confidence: 99%

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confidence: 99%

“…Thus a feeding regimen with an option of eating palatable sucrose and lard may attenuate hypophagic responses to restraint stress (48). Restraint stress applied acutely and repeatedly usually promotes anorectic effects in rats fed regular chow (24,74,77).…”

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Intermittent access to sucrose increases sucrose-licking activity and attenuates restraint stress-induced activation of the lateral septum

Martin

Timofeeva

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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Martin J, Timofeeva E. Intermittent access to sucrose increases sucroselicking activity and attenuates restraint stress-induced activation of the lateral septum. Am J Physiol Regul Integr Comp Physiol 298: R1383-R1398, 2010. First published March 3, 2010 doi:10.1152/ajpregu.00371.2009.-Intermittent access to palatable food can attenuate anorectic and hormonal responses to stress in rats. The neuronal mechanisms of modulation of stress response by diets are not fully understood. The present study was conducted to create rat models with intermittent access to sucrose that demonstrate resistance to stress-induced hypophagia, to study the pattern of sucrose consumption by these rat models, and to investigate in which brain structures intermittent sucrose regimens modify stressinduced neuronal activation. The obtained results demonstrate that 6-wk intermittent access to sucrose without food restriction (4 day/wk ad libitum access to sucrose in addition to chow, and following 3 day/wk exclusive feeding of chow; SIA rats) and combined with food restriction (4 day/wk access to chow and sucrose restricted to 2 h/day, and following 3 days/wk on unrestricted chow; SIR rats) increased sucrose-licking activity. The alterations in the rats' feeding behavior were accompanied by a resistance of their body weight gain and food intake to 1-h restraint stress applied once per week. The chronic intermittent sucrose consumption significantly lowered, in the SIA and SIR rats, the levels of expression of corticotropin-releasing factor type 2 receptor and restraint stress-induced expression of c-fos mRNA in the medioventral part of the lateral septum. Conversely, the levels of the corticotropin-releasing factor type 2 receptor transcript in the ventromedial hypothalamic nucleus were decreased only in the foodrestricted SIR rats. The lower stress-induced neuronal activation in the medioventral part of the lateral septum may contribute to the attenuated anorectic stress response in the rats maintained on intermittent sucrose regimens. restraint stress; c-fos; corticotropin-releasing factor; hypothalamicpituitary-adrenal axis; corticotropin-releasing factor type 2 receptor ACCUMULATED EVIDENCE STRONGLY suggests that palatable diets can modify the effects of stress. Thus a feeding regimen with an option of eating palatable sucrose and lard may attenuate hypophagic responses to restraint stress (48). Restraint stress applied acutely and repeatedly usually promotes anorectic effects in rats fed regular chow (24,74,77). The anorectic effect of restraint stress apparently depends on the brain corticotropin-releasing factor (CRF) system, since the central application of the nonspecific CRF antagonist ␣-helical CRF considerably reversed restraint stress-induced anorexia (77). CRF is a key neuropeptide-regulating activity of the hypothalamic-pituitary-adrenal (HPA) axis. Activation of the HPA axis in response to stress has been extensively characterized. Briefly, exposure to stress activates the neurons in the parvocellular part of the paraventr...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Intermittent access to sucrose increases sucrose-licking activity and attenuates restraint stress-induced activation of the lateral septum

Martin

Timofeeva

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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“…We monitored the effect of saccharin intake on the hippocampal Schaffer collateral synaptic plasticity. In this trial, we maximized the sensory intensity not only by the concentration of saccharin but also by way of restriction of saccharin self-administration to 2 hr per day, because continuous administration of palatable food did not change the stress-induced corticosterone release in rat [24]. We have previously reported that not only the hippocampal function but also HPA axis activity responding to reward stimuli exhibit gender differences [25], therefore we also separately monitored the difference in LTP formation between genders.…”

Section: Discussionmentioning

confidence: 99%

Effects of Saccharin Intake on Hippocampal and Cortical Plasticity in Juvenile and Adolescent Rats

Park

Yoo

Kim

et al. 2010

Korean J Physiol Pharmacol

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The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have revealed that deprivation of specific sensory experiences can modify the structure and function of the central nervous system; however, the effects of sensory overload remains unclear. Here we studied the effect of overloading the taste sense in the early period of life on the synaptic plasticity of rat hippocampus and somatosensory cortex. W e prepared male and female Sprague Dawley rats with ad libitum access to a 0.1% saccharin solution for 2 hrs per day for three weeks after weaning on postnatal day 22. Saccharin consumption was slightly increased in males compared with females; however, saccharin intake did not affect chow intake or weight gain either in male or in female rats. W e examined the effect of saccharin-intake on long term potentiation (LTP) formation in hippocampal Schaffer collateral pathway and somatosensory cortex layer IV -II/III pathways in the 6-week old saccharin-fed rats. There was no significant difference in LTP formation in the hippocampus between the control group and saccharin-treated group in both male and female rats. Also in the somatosensory cortex, we did not see a significant difference in LTP among the groups. Therefore, we conclude that saccharin-intake during 3∼ 6 weeks may not affect the development of physiological function of the cortical and hippocampal synapses in rats.

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Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge‐like palatable food consumption in female rats

Bonaventura

Ubaldi

Giusepponi

et al. 2017

Intl J Eating Disorders

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Rationale The interaction between dieting and stress is a key factor for triggering binge episodes on palatable food in human binge eaters. Corticotropin releasing factor (CRF) mechanisms are known to play a pivotal role in the regulation of this maladaptive behavior. Objective The present study evaluated the effect of systemic injection of the CRF1 receptor antagonist R121919, the corticosterone synthesis inhibitor metyrapone and central amygdala (CeA) injections of the nonselective CRF antagonist D-Phe-CRF(12– 41) in rats in which binge eating was evoked by stress and cycles of food restriction. Method Female rats were subjected or not to repeated cycles of regular chow food restriction/refeeding during which they were also given limited access (2 h) to palatable food. On the test day, rats were either exposed or not to the sight of the palatable food for 15 min without allowing access, before assessing food consumption. Results Systemic injections of R121919, but not of the metyrapone, blocked binge-like eating behavior. Restricted and stressed rats showed up-regulation of crh1 receptor mRNA signal in the bed nucleus of the stria terminalis and CeA but not in basolateral amygdala (BLA) or in the paraventricular nucleus. Injection D-Phe-CRF(12– 41) in CeA but not in the BLA blocked binge-like eating behavior. Discussion These findings demonstrate that extra-hypothalamic CRF1 receptors, rather than those involved in endocrine functions, are involved in binge eating and the crucial role of CRF receptors in CeA. CRF1 receptor antagonism may represent a novel pharmacological treatment for binge-related eating disorders.

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Binge-type eating attenuates corticosterone and hypophagic responses to restraint stress

Cited by 69 publications

References 36 publications

Intermittent access to sucrose increases sucrose-licking activity and attenuates restraint stress-induced activation of the lateral septum

Intermittent access to sucrose increases sucrose-licking activity and attenuates restraint stress-induced activation of the lateral septum

Effects of Saccharin Intake on Hippocampal and Cortical Plasticity in Juvenile and Adolescent Rats

Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge‐like palatable food consumption in female rats

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