BINOL-phosphoric acids-catalyzed furylogous pinacol rearrangement of 1-[5-(hydroxy-diaryl-methyl)-furan-2-yl]-cyclobutanols into spiro cyclopentanones

Advances and Perspectives in Pinacol Rearrangement Reactions: A Comprehensive Review

“…The paper titled "BINOL-Phosphoric Acids-Catalyzed Furylogous Pinacol Rearrangement of 1-[5-(Hydroxy-diaryl-methyl)-furan-2-yl]-cyclobutanols into Spiro Cyclopentanones" published in the journal Tetrahedron investigates the application of BINOL-phosphoric acids as catalysts for the furylogous pinacol rearrangement of 1-[5-(hydroxy-diaryl-methyl)-furan-2-yl]-cyclobutanols, leading to the formation of spiro cyclopentanones. The study focuses on developing an efficient and versatile method for the synthesis of complex spirocyclic compounds [33]. The authors introduce the significance of spiro cyclopentanones due to their presence in various natural products and their diverse biological activities.…”

Enantioselective Acyloin Rearrangement of Acyclic Aldehydes Catalyzed by Chiral Oxazaborolidinium Ion

“…The acyloin rearrangement, − involving 1,2-aryl or -alkyl migration to the carbonyl group, is a useful synthetic method for structural reorganization of organic molecules that renders the synthesis of various natural products feasible. , Through the acyloin rearrangement, α-hydroxy ketone (acyloin) can be easily synthesized as a versatile building block , for many natural products and pharmaceuticals. , However, the inherent reversibility of this reaction involving an equilibrium between two isomers has made it highly challenging to develop catalytic enantioselective rearrangements.…”