Bio-antimutagenic Effects of Sesquiterpene Lactones from Costus Root Oil

Kuroda, Miyuki; Yoshida, Daisuke; Kodama, Hisashi

doi:10.1080/00021369.1987.10868046

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2000

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“…There are several reports of antimutagenicity studies on the terpenoid (Ragasa et al, 1997a,b;Kuroda et al, 1987;Kakinuma et al, 1987). We have reported antimutagenic activity and suppressive effects of SOS response of a sesquiterpenoid (β-eudesmol).…”

Section: Resultsmentioning

confidence: 99%

Suppression of the Furylfuramide-Induced SOS Response by Monoterpenoids with a p-Menthane Skeleton Using the Salmonella typhimurium TA1535/pSK1002 Umu Test

Miyazawa

Okuno

Nakamura

et al. 2000

J. Agric. Food Chem.

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Suppression of the furylfuramide-induced SOS response by 25 kinds monoterpenoids (hydrocarbons, alcohols, ketones, and aldehydes) with a p-menthane skeleton was studied. Suppression of the SOS-inducing activity by monoterpenoids was determined in the umu test using Salmonella typhimurium TA1535/pSK1002. The terpene alcohols, ketones, and aldehydes had potent suppressive effects, but the hydrocarbons did not. Especially, (+)-menthol, (+)-pulegone, piperitenone, and cuminaldehyde were shown to have the most potent suppressive effects, and the ID(50) (dose for 50% inhibition) was 0.52 micromol/mL.

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Section: Resultsmentioning

confidence: 99%