Bio‐effect of nanoparticles in the cardiovascular system

Yu, Xiaohong; Hong, Fashui; Zhang, Yu‐Qing

doi:10.1002/jbm.a.35804

Cited by 58 publications

(46 citation statements)

References 146 publications

(296 reference statements)

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“…4,5 Therefore, it is critical to find an effective and safe additive ingredient to develop novel fish collagen wound healing materials. It was reported that bioactive glass (BG) could be incorporated into the polymer matrix, and this was found to enhance the mechanical and biological properties of the composites.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Zhou¹,

Sui²,

Mo³

et al. 2017

IJN

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The development of skin wound dressings with excellent properties has always been an important challenge in the field of biomedicine. In this study, biomimetic electrospun fish collagen/bioactive glass (Col/BG) nanofibers were prepared. Their structure, tensile strength, antibacterial activity and biological effects on human keratinocytes, human dermal fibroblasts and human vascular endothelial cells were investigated. Furthermore, the Sprague Dawley rat skin defect model was used to validate their effect on wound healing. The results showed that compared with pure fish collagen nanofibers, the tensile strength of the Col/BG nanofibers increased to 21.87±0.21 Mpa, with a certain degree of antibacterial activity against Staphylococcus aureus . It was also found that the Col/BG nanofibers promoted the adhesion, proliferation and migration of human keratinocytes. Col/BG nanofibers induced the secretion of type one collagen and vascular endothelial growth factor by human dermal fibroblasts, which further stimulated the proliferation of human vascular endothelial cells. Animal experimentation indicated that the Col/BG nanofibers could accelerate rat skin wound healing. This study developed a type of multifunctional and biomimetic fish Col/BG nanofibers, which had the ability to induce skin regeneration with adequate tensile strength and antibacterial activity. The Col/BG nanofibers are also easily available and inexpensive, providing the possibility for using as a functional skin wound dressing.

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Section: Introductionmentioning

confidence: 99%

Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Zhou¹,

Sui²,

Mo³

et al. 2017

IJN

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“…Stres-strain eğrisinden maksimum stres, maksimum strain, dayanıklılık ve Young modülü hesaplanmıştır. 5 Birim alana etki eden maksimum kuvvet olarak tanımlanan maksimum stres (σ) maksimum kırılma kuvvetinin alan (A) değerine bölünmesiyle (σ=F max /A), maksimum strain (ε), maksimum deformasyon miktarının kemiğin kuvvet uygulanmadan önceki değerine bölünmesiyle (ε=∆L/L 1 ), dayanıklılık (D) stres-strain eğrisinin altında kalan alanın hesaplanmasıyla (D=(σ*ε)/2) ve Young modül (Y) ise stres/strain oranından hesap- …”

Section: Bi̇yomekani̇k Testunclassified

“…Bu parçacıklar başta tıp olmak üzere elektronik, otomotiv, tekstil, boya, kozmetik ve gıda alanlarında yaygın olarak kullanılmaktadır. 5 Nanoteknolojide sıklıkla gümüş, titanyum dioksit, çinko oksit, altın, silisyum dioksit gibi çeşitli metaller kullanılmakta-dır. Bunlardan gümüş; atık su ve kaynak su temizliği ile tekstil ve kozmetikte, farmakolojide; titanyum dioksit kozmetikte, gıda sektöründe, araç kaplamalarında, ilaç taşıyıcı sistemlerde, çinko oksit kozmetik, gıda paketleme ve araç kaplamada; altın ise özellikle tıpta kullanım alanı bulmaktadır.…”

unclassified

“…15 Nanoteknolojide önemli bir yere sahip olan ve yazıcı tonerlerinde, tekstil ve boyada, kozmetikte, tıbbi görüntüleme ve ilaç taşıyıcı sistemlerde kullanılan silisyum dioksit nanoparçacıklarının vü-cuda çeşitli yollarla girebildiği ve kardiyotoksik, sitotoksik, genotoksik etkilerle birlikte kalp, karaciğer ve böbrek gibi yaşamsal organlarda hasara yol açtığı bildirilmektedir. 5,[16][17][18][19] Bilgilerimize göre, literatürde SiO 2 nanoparçacıklarının kemik biyomekaniği üzerine etkisini inceleyen bir çalışma bulunmamaktadır.…”

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Effects of Silica Nanoparticles on Rat Cortical Bone Biomechanics: Experimental Study

Çömelekoğlu¹,

Söğüt²,

Uzun³

et al. 2017

Turkiye Klinikleri J Lab Anim

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oyutu 1-100 nm aralığında yer alan parçacıklar "nanoparçacık" olarak adlandırılmaktadır. Nanoparçacıklar; elektron tutuculuğu, parçacık şekilleri, parçacık yüzey kimyası, ısı ve elektriksel iletkenlik, manyetik ve optik olmak üzere birçok fizikokimyasal özelliğe sahiptir. [1][2][3] Nanoparçacıkların etkileri boyutlarına bağlı olarak değişmektedir. Boyutları A An na ah ht ta ar r K Ke el li im me el le er r: : Nanopartiküller; biyomekanik; kırıklar, kemik A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Silica (SiO 2 ) nanoparticles are widely used in fields including agriculture, textile, electronics, cosmetic, painting industry and medicine. SiO 2 nanoparticles enter the body in different ways and have a toxic effect on the tissue and organs. In this study, the effect of SiO 2 nanoparticles were investigated on the bone biomechanics. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Fourteen 12-week-old Wistar albino male rats were divided randomly to a control (n=7) and experimental (n=7) groups. Animals in the experimental group were intraperitoneally administered at a dose of 150 μg/mL 6 nm sized SiO 2 nanoparticles for 28 days. The rats in the control group were given an equal volume of saline. Bone biomechanical parameters were measured in cortical femur with tensile testing machine and breaking force, deformation, energy, ultimate stress, ultimate strain, toughness and elastic modulus were calculated for all cortical femurs. R Re es su ul lt ts s: : In the experimental group, breaking force, energy, ultimate stress, and toughness were significantly lower than those of the control group (p<0.05). Deformation, ultimate strain and elastic modulus were not changed in experimental group when compared to control group (p>0.05). C Co on nc cl lu us si io on n: : The results of the present study indicate that the administration 150 μg/mL of 6 nm sized SiO 2 nanoparticles reduce of the biomechanical quality of the bone. This reduction may thought to increase the risk of fracture of cortical bone.

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“…Many benefits are expected from their use but potential toxic effects related to NPs exposures have been highlighted [1][2][3][4]. Due to their small size NPs are able to enter into our body.…”

Section: Introductionmentioning

confidence: 99%

Nano-Scaled Particles and Fibres Occupational Exposure Assessment: An Integrated Approach from Air Sampling to Skin and Surface Contamination

Prodi¹,

Filon²

2016

Nano BioMed ENG

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Workers may be exposed to nanoparticles (NPs) by inhalation, cutaneous contact and gastroenteric pathways, but today there is no standardized method for either assessing or monitoring the occupational exposure. Moreover, there is no all-in-one assessment strategy, so it is preferable to consider different perspectives. Every assessment should be preceded by a preliminary analysis of the workplace in order to gather useful data on the potential exposure sources, which will help in outlining the assessment strategy. The purpose of air monitoring should be to characterize NP emissions and assess, as a minimum, the mass, particle number concentration, granulometric distribution, specific surface and chemical composition. There are several techniques which may assess these characteristics: the most used in real occupational contexts are mobility particle sizers, particle counters (optical, condensation, etc.), surface area monitors, while personal samplers are promising tools which still have been used almost only in research or controlled contexts. Skin and surfaces may be sampled according to the nature of substances and the circumstances of exposure. Sampling methods can be divided in three main categories: interception (e.g. carbon tabs), removal (e.g. adhesive tape stripping, wiping), in situ methods (e.g. UV fluorescence). Chemical analysis methods (e.g. spectroscopy) and electron microscopy techniques may enhance available data. Considering the available information, we suggest a stepwise approach for risk assessment composed of three steps, starting from a quick and relatively cheap screening method to assess exposure, followed by 2 gradually more accurate but costly approaches to perform whether a significant exposure is detected.

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Bio‐effect of nanoparticles in the cardiovascular system

Cited by 58 publications

References 146 publications

Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Effects of Silica Nanoparticles on Rat Cortical Bone Biomechanics: Experimental Study

Nano-Scaled Particles and Fibres Occupational Exposure Assessment: An Integrated Approach from Air Sampling to Skin and Surface Contamination

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