Bio-engineered palladium nanoparticles: model for risk assessment study of automotive particulate pollution on macrophage cell lines

Aarzoo,; Naqvi, Saba; Agarwal, Nidhi; Singh, Manoj; Samim, Mohd

doi:10.1039/d0ra09336j

Cited by 12 publications

(5 citation statements)

References 70 publications

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“…This observation is consistent with previous studies. 42 , 52 , 53 The disappearance of the characteristic Pd 2+ peak and the emergence of a linear curve in the UV–vis spectra further confirm the successful formation of PdNPs in colloidal form.…”

Section: Resultsmentioning

confidence: 63%

“…The UV–vis spectrum of PdCl 2 exhibited a maximum absorbance (λmax) at approximately 425 nm (400–450 nm), which is known as the characteristic peak of Pd 2+ ions. ,, This peak is attributed to electronic d-d transition in Pd 2+ ions with a d 8 electron configuration. In contrast, the UV–vis spectra of 20@PdNPs, 80@PdNPs, and PdNRs displayed a different pattern.…”

Section: Resultsmentioning

confidence: 99%

“…The characteristic peak of Pd 2+ ions at around 425 nm was absent, and a linear curve was observed instead, indicating the formation of PdNPs in their zerovalent state (Pd 0 ). This observation is consistent with previous studies. ,, The disappearance of the characteristic Pd 2+ peak and the emergence of a linear curve in the UV–vis spectra further confirm the successful formation of PdNPs in colloidal form.…”

Section: Resultsmentioning

confidence: 99%

“…The lower dose (1 μg/kg) was chosen to simulate exposure levels resembling those of the general population living near highways. Studies have reported Pd levels ranging from 1 to 1000 μg/kg in road dust and roadside soil. − Therefore, the selected doses in this study resemble occupational and environmental exposure scenarios.…”

Section: Methodsmentioning

confidence: 99%

“…Studies have reported Pd levels ranging from 1 to 1000 μg/kg in road dust and roadside soil. 42 − 44 Therefore, the selected doses in this study resemble occupational and environmental exposure scenarios.…”

Section: Methodsmentioning

confidence: 99%

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Palladium Nanoparticles and Lung Health: Assessing Morphology-Dependent Subacute Toxicity in Rats and Toxicity Modulation by Naringin – Paving the Way for Cleaner Vehicular Emissions

Aarzoo,

Siddiqui,

Hasan

et al. 2024

ACS Omega

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The release of palladium nanoparticles (PdNPs) from autocatalytic converters has raised concerns regarding public health and the environment due to their emergence as anthropogenic contaminants. With growing vehicular population, there is an urgent need for comprehensive toxicological studies of PdNPs to mitigate their risk. The present study aims to investigate the effects of spherical PdNPs with average sizes of 20 and 80 nm, as well as Pd nanorods, on the lung function of female Wistar rats following oral exposure to environmentally relevant doses (1 and 10 μg/kg) over a period of 28 days. Various biological parameters were evaluated, including liver and kidney biochemical changes, lung oxidative stress markers (SOD, CAT, GSH, LPO), lung inflammatory markers (IL-1β, IL-8, IL-6, and TNF-α), and histopathological alterations in the lungs. Additionally, the potential mitigating effects of naringin on PdNPs-induced toxicity were examined. The results demonstrate a significant increase in oxidative stress, the onset of inflammation, and histological changes in lung alveolar sacs upon exposure to all tested particles. Specifically, 20@ PdNPs and PdNRs exhibited higher cytotoxicity and pro-inflammatory properties compared to 80@PdNPs. Naringin effectively attenuated the pulmonary toxicity induced by PdNPs by modulating oxidative and inflammatory pathways. These findings contribute to the sustainable development of PdNPs for their future applications in the biomedical and environmental sectors, ensuring the advancement of safe and sustainable nanotechnology.

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Section: Resultsmentioning

confidence: 63%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Palladium Nanoparticles and Lung Health: Assessing Morphology-Dependent Subacute Toxicity in Rats and Toxicity Modulation by Naringin – Paving the Way for Cleaner Vehicular Emissions

Aarzoo,

Siddiqui,

Hasan

et al. 2024

ACS Omega

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Interaction of Nano-TiO2 with Plants: Preparation and Translocation

Moodley

Arumugam

2021

Advances in Science, Technology &Amp; Innovation

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Oxali-palladium nanoparticle synthesis, characterization, protein binding, and apoptosis induction in colorectal cancer cells

Golestannezhad,

Divsalar,

Badalkhani-Khamseh

et al. 2024

J Mater Sci: Mater Med

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This paper focuses on the synthesis of nano-oxali-palladium coated with turmeric extract (PdNPs) using a green chemistry technique based on the reduction in the Pd (II) complex by phytochemicals inherent in turmeric extract. PdNPs were examined and characterized using Field Emission Scanning Electron Microscopy (FESEM), Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR), and Atomic Force Microscopy (AFM). Using different spectroscopic and molecular dynamics simulations, a protein-binding analysis of the produced nanoparticle was conducted by observing its interaction with human serum albumin (HSA). Lastly, the cytotoxic effects and apoptotic processes of PdNPs were studied against the HCT116 human colorectal cell line using the MTT assay and flow cytometry tests. According to the findings, PdNPs with spherical and homogenous morphology and a size smaller than 100 nm were generated. In addition, they can induce apoptosis in colorectal cancer cells in a dose-dependent manner with a lower Cc50 (78 µL) than cisplatin and free oxali-palladium against HCT116 cells. The thermodynamic characteristics of protein binding of nanoparticles with HSA demonstrated that PdNPs had a great capacity for quenching and interacting with HSA through hydrophobic forces. In addition, molecular dynamics simulations revealed that free oxali-palladium and PdNP attach to the same area of HSA via non-covalent interactions. It is conceivable to indicate that the synthesized PdNPs are a potential candidate for the construction of novel, nature-based anticancer treatments with fewer side effects and a high level of eco-friendliness. Graphical Abstract

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Bio-engineered palladium nanoparticles: model for risk assessment study of automotive particulate pollution on macrophage cell lines

Abstract: The surge in vehicular activity in densely populated areas has led to an increased concentration of airborne palladium nanoparticles (PdNPs) in the environment.

Cited by 12 publications

References 70 publications

Palladium Nanoparticles and Lung Health: Assessing Morphology-Dependent Subacute Toxicity in Rats and Toxicity Modulation by Naringin – Paving the Way for Cleaner Vehicular Emissions

Palladium Nanoparticles and Lung Health: Assessing Morphology-Dependent Subacute Toxicity in Rats and Toxicity Modulation by Naringin – Paving the Way for Cleaner Vehicular Emissions

Interaction of Nano-TiO2 with Plants: Preparation and Translocation

Oxali-palladium nanoparticle synthesis, characterization, protein binding, and apoptosis induction in colorectal cancer cells

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