Bio-functional strontium-containing photocrosslinked alginate hydrogels for promoting the osteogenic behaviors

Zhao, Delu; Wang, Xin; Tie, Chaorong; Cheng, Bo; Yang, Sisi; Sun, Zhen; Yin, Miaomiao; Li, Xiaobao; Yin, Miao

doi:10.1016/j.msec.2021.112130

Cited by 23 publications

(35 citation statements)

References 85 publications

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“…The release behavior of Sr ions in this study showed a rapid burst release over the first 1 day, which is similar as those reported in previous literatures. [ 18,30 ] This might be due to the large difference in Sr ions concentration between the initial release medium and the material, and Sr ions in the SPEEK‐CS@Sr material could be easily exchanged by sodium ions in the release medium. [ 30 ] Then, the release rate of strontium ions was significantly slowed down, and the content of Sr 2+ ions in the medium is keeped to be a stable level from day 1 to 15.…”

Section: Resultsmentioning

confidence: 99%

“…[ 18,30 ] This might be due to the large difference in Sr ions concentration between the initial release medium and the material, and Sr ions in the SPEEK‐CS@Sr material could be easily exchanged by sodium ions in the release medium. [ 30 ] Then, the release rate of strontium ions was significantly slowed down, and the content of Sr 2+ ions in the medium is keeped to be a stable level from day 1 to 15. This indicated that the SPEEK‐CS@Sr material can release strontium ions continuously and stablely.…”

Section: Resultsmentioning

confidence: 99%

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Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti‐Inflammation, Angiogenesis, Osteogenic Properties

Zheng

et al. 2022

Adv Healthcare Materials

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Besides inducing osteogenic differentiation, the surface modification of poly(ether ether ketone) (PEEK) is highly expected to improve its angiogenic activity and reduce the inflammatory response in the surrounding tissue. Herein, strontium chondroitin sulfate is first attempted to be introduced into the surface of sulfonated PEEK (SPEEK-CS@Sr) based on the Schiff base reaction between PEEK and ethylenediamine (EDA) and the amidation reaction between EDA and chondroitin sulfate (CS). The surface characteristics of SPEEK-CS@Sr implant are systematically investigated, and its biological properties in vitro and in vivo are also evaluated. The results show that the surface of SPEEK-CS@Sr implant exhibits a 3D microporous structure and good hydrophilicity, and can steadily release Sr ions. Importantly, the SPEEK-CS@Sr not only displays excellent biocompatibility, but also can remarkably promote cell adhesion and spread, improve osteogenic activity and angiogenic activity, and reduce the inflammatory response compared to the original PEEK. Therefore, this study presents the surface modification of PEEK material by simple chemical grafting of strontium chondroitin sulfate to improve its angiogenesis, anti-inflammation, and osteogenic properties, and the as-fabricated SPEEK-CS@Sr has the potential to serve as a promising orthopedic implant in bone tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti‐Inflammation, Angiogenesis, Osteogenic Properties

Zheng

et al. 2022

Adv Healthcare Materials

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“…Even with the aforementioned efforts, the lack of research on HA hydrogels containing SrRan for local drug delivery is evident. Several studies can be found on strontium ion release from alginate ( Place et al, 2011 ), carboxymethylcellulose (CMCA) ( Nardone et al, 2012 ), photocrosslinked methacrylated alginate (PMA) ( Zhao et al, 2021 ) and methoxy (polyethylene glycol)-polyester hydrogels ( Peng et al, 2017 ), as well as injectable methylcellulose (MC) polymeric hydrogel ( Chiang et al, 2021 ). It was shown that strontium ion release from the alginate hydrogels, in phosphate-buffered saline (PBS), had a rapid burst in the first 8 h and then gradually diminished in 5–10 days before settling to a constant rate ( Place et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

“…It was shown that strontium ion release from the alginate hydrogels, in phosphate-buffered saline (PBS), had a rapid burst in the first 8 h and then gradually diminished in 5–10 days before settling to a constant rate ( Place et al, 2011 ). From PMA hydrogels, a rapid burst was observed over the first day, and then the drug release was significantly slowed down until the seventh day ( Zhao et al, 2021 ). Also, it was demonstrated that the release of strontium ions from CMCA hydrogels in an osteogenic medium enhanced the bone cell differentiation of PA2-E12 cell lines ( Nardone et al, 2012 ), but in PMA hydrogels, osteogenic differentiation was observed for MC3T3-E1 cells ( Zhao et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…From PMA hydrogels, a rapid burst was observed over the first day, and then the drug release was significantly slowed down until the seventh day ( Zhao et al, 2021 ). Also, it was demonstrated that the release of strontium ions from CMCA hydrogels in an osteogenic medium enhanced the bone cell differentiation of PA2-E12 cell lines ( Nardone et al, 2012 ), but in PMA hydrogels, osteogenic differentiation was observed for MC3T3-E1 cells ( Zhao et al, 2021 ). In most of these studies, other strontium salts (SrCO 3 and SrCl 2 ) were used rather than ranelate ( Chiang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Calcium Phosphate/Hyaluronic Acid Composite Hydrogels for Local Antiosteoporotic Drug Delivery

Svarca

Grava²,

Dubņika³

et al. 2022

Front. Bioeng. Biotechnol.

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Despite the bone ability of self-regeneration, large bone defects require surgical intervention. Likewise, when it comes to osteoporotic bone fractures, new approaches should be considered a supportive mechanism for the surgery. In recent years, more and more attention has been attracted to advanced drug delivery systems for local osteoporosis treatment, combining appropriate biomaterials with antiosteoporotic drugs, allowing simultaneously to regenerate the bone and locally treat the osteoporosis. Within the current research, hyaluronic acid/strontium ranelate (HA/SrRan), HA/calcium phosphate nanoparticles (HA/CaP NPs), and HA/CaP NPs/SrRan hydrogels were prepared. The effect of CaP and SrRan presence in the composites on the swelling behavior, gel fraction, molecular structure, microstructure, and SrRan and Sr2+ release, as well as in vitro cell viability was evaluated. Obtained results revealed that the route of CaP nanoparticle incorporation into the HA matrix had a significant effect on the hydrogel gel fraction, rheological properties, swelling behavior, and microstructure. Nevertheless, it had a negligible effect on the release kinetics of SrRan and Sr2+. The highest cell (3T3) viability (>80%) was observed for HA hydrogels, with and without SrRan. Moreover, the positive effect of SrRan on 3T3 cells was also demonstrated, showing a significant increase (up to 50%) in cell viability if the used concentrations of SrRan were in the range of 0.05–0.2 μg/ml.

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A Ubiquitin‐Competitive Strategy Based on the Element Microenvironment to Treat Osteoarthritis

Kong,

Yang,

Chang

et al. 2024

Adv Funct Materials

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Recent research on ferroptosis and cuproptosis has underscored the crucial role of trace element regulation in osteoarthritis (OA) treatment. However, research systematically addressing the alterations in nutrient elements in OA cartilage is lacking. This study is initiated using clinical specimens to quantify metal element concentrations in both damaged and intact cartilage to identify deficient trace elements within the inflammatory and senescent microenvironments of OA. Based on the preliminary findings of selenium (Se) and gallium (Ga) deficiencies in OA cartilage, tailored nanoparticles based on Se and Ga are designed and validated for their antioxidant ability. GaSex nanoparticles demonstrated significant efficacy in mitigating chondrocyte degeneration and extracellular matrix degradation induced by inflammatory factors and in alleviating cartilage abrasion, hyperalgesia, and abnormal gait in a destabilization of the medial meniscus (DMM) mouse model. Mechanistically, GaSex nanoparticles activated the Nrf2 pathway and competitively inhibited the ubiquitin‐mediated degradation of Gpx4, thus inhibiting ferroptosis. This study systematically designed GaSex nanoparticles based on the imbalance of trace elements within the OA knee joint microenvironment and demonstrated robust antioxidant capabilities and remarkable competitive properties for ubiquitin, thereby providing a novel therapeutic solution for OA treatment.

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Bio-functional strontium-containing photocrosslinked alginate hydrogels for promoting the osteogenic behaviors

Cited by 23 publications

References 85 publications

Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti‐Inflammation, Angiogenesis, Osteogenic Properties

Surface Modification of Poly(ether ether ketone) by Simple Chemical Grafting of Strontium Chondroitin Sulfate to Improve its Anti‐Inflammation, Angiogenesis, Osteogenic Properties

Calcium Phosphate/Hyaluronic Acid Composite Hydrogels for Local Antiosteoporotic Drug Delivery

A Ubiquitin‐Competitive Strategy Based on the Element Microenvironment to Treat Osteoarthritis

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