Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

Massella, Daniele; Argenziano, Monica; Ferri, Ada; Guan, Jing; Giraud, Stéphane; Cavalli, Roberta; Barresi, Antonello; Salaün, Fabien

doi:10.3390/pharmaceutics11080403

Cited by 39 publications

(23 citation statements)

References 221 publications

(299 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Normal skin is lubricated and slightly acidic, which protects it from the growth of pathogens. Furthermore, Langerhans cells, which are present in the epidermis, also protect from infections [ 28 , 29 ].…”

Section: Skin Structurementioning

confidence: 99%

Advanced Hydrogels as Wound Dressings

2020

View full text Add to dashboard Cite

Skin is the largest organ of the human body, protecting it against the external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by skin substitutes. Tremendous progress has been made in the field of skin tissue engineering, in recent years, to develop new skin substitutes. Among them, hydrogels are one of the candidates with most potential to mimic the native skin microenvironment, due to their porous and hydrated molecular structure. They can be applied as a permanent or temporary dressing for different wounds to support the regeneration and healing of the injured epidermis, dermis, or both. Based on the material used for their fabrication, hydrogels can be subdivided into two main groups—natural and synthetic. Moreover, hydrogels can be reinforced by incorporating nanoparticles to obtain “in situ” hybrid hydrogels, showing superior properties and tailored functionality. In addition, different sensors can be embedded in hydrogel wound dressings to provide real-time information about the wound environment. This review focuses on the most recent developments in the field of hydrogel-based skin substitutes for skin replacement. In particular, we discuss the synthesis, fabrication, and biomedical application of novel “smart” hydrogels.

show abstract

Section: Skin Structurementioning

confidence: 99%

Advanced Hydrogels as Wound Dressings

2020

View full text Add to dashboard Cite

show abstract

“…ticles, and micro-hydrogel [36]. In addition to the above structures, dendrimers are other interesting polymeric forms for biofunctional tissue production [73].…”

Section: Stimuli-responsive Drug Carrier For Delivering Bioactive Submentioning

confidence: 99%

“…[ 72 ]. Massella et al expand the possible drug carriers for textile modification with nanospheres, micro- and nanocapsules, liposomes, inorganic particles, and micro-hydrogel [ 36 ]. In addition to the above structures, dendrimers are other interesting polymeric forms for biofunctional tissue production [ 73 ].…”

Section: Stimuli-responsive Drug Carrier For Delivering Bioactive mentioning

confidence: 99%

“…Several excellent review articles describing applications of textile materials and different pharmaceutical nanocariers in topical and transdermal drug delivery have been published [ 36 , 37 , 38 ]. The increased number of studies in this field is as a result of the current interest in the development of the platform for continuous monitoring and assisting the health status of individuals via telemedicine [ 39 ] and personalized medicine [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

2021

View full text Add to dashboard Cite

Textile materials, as a suitable matrix for different active substances facilitating their gradual release, can have an important role in skin topical or transdermal therapy. Characterized by compositional and structural variety, those materials readily meet the requirements for applications in specific therapies. Aromatherapy, antimicrobial substances and painkillers, hormone therapy, psoriasis treatment, atopic dermatitis, melanoma, etc., are some of the areas where textiles can be used as carriers. There are versatile optional methods for loading the biologically active substances onto textile materials. The oldest ones are by exhaustion, spraying, and a pad-dry-cure method. Another widespread method is the microencapsulation. The modification of textile materials with stimuli-responsive polymers is a perspective route to obtaining new textiles of improved multifunctional properties and intelligent response. In recent years, research has focused on new structures such as dendrimers, polymer micelles, liposomes, polymer nanoparticles, and hydrogels. Numerous functional groups and the ability to encapsulate different substances define dendrimer molecules as promising carriers for drug delivery. Hydrogels are also high molecular hydrophilic structures that can be used to modify textile material. They absorb a large amount of water or biological fluids and can support the delivery of medicines. These characteristics correspond to one of the current trends in the development of materials used in transdermal therapy, namely production of intelligent materials, i.e., such that allow controlled concentration and time delivery of the active substance and simultaneous visualization of the process, which can only be achieved with appropriate and purposeful modification of the textile material.

show abstract

“…Electrospinning is a promising and versatile technique that is used to fabricate polymeric nanofibers for a wide variety of biomedical applications such as drug delivery systems [1], scaffolds for tissue engineering [2] [3] [4] [5], wound dressing [6]. Fibers produced by electrospinning have controlled dimensions, about a few nanometers, and porosity, which give the produced fibers a high surface area [5] [7].…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Electrospinning Conditions by Box-Behnken Design to Prepare Poly(Vinyl Alcohol)/Chitosan Crosslinked Nanofibers

Viana¹,

Ferreira²,

Azero³

et al. 2020

MSCE

View full text Add to dashboard Cite

Electrospun poly(vinyl alcohol)/chitosan nanofibers had their solution and process parameters optimized using a Box-Behnken design and desirability function. Four factors (applied voltage, flow rate, distance tip-to-plate and amount of chitosan) were varied to produce electrospun mats with a low fiber diameter. An empirical model was developed for each response using response surface methodology (RSM), which revealed that flow rate had no significant influence on the assessed responses. With desirability function, the optimal conditions to produce the nanofibers were applied voltage of 13.1 kV, 30% chitosan concentration and distance tip-to-plate of 10 cm. The fiber diameter and standard deviation were 196.5 ± 28.3 nm, compared to the predicted values of 185.9 ± 26.8 nm. The desirability function allied with Box-Benhken design proved themselves important tools to predict process parameters for the development of nanofibers. The mats were crosslinked with glutaraldehyde for 24 h and 48 h and presented good water stability and enhanced mechanical properties.

show abstract

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

Cited by 39 publications

References 221 publications

Advanced Hydrogels as Wound Dressings

Advanced Hydrogels as Wound Dressings

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

Optimization of the Electrospinning Conditions by Box-Behnken Design to Prepare Poly(Vinyl Alcohol)/Chitosan Crosslinked Nanofibers

Contact Info

Product

Resources

About