Bio-guided isolation of plant growth regulators from allelopathic plant-<i>Codonopsis pilosula</i>: phyto-selective activities and mechanisms

Xie, Ming‐Jin; Liu, Jing-Kun; Yan, Zhiqiang; Li, Xiuzhuang; Yang, Xiaoyan; Jin, Hui; Su, Anxiang; Qin, Bo

doi:10.1039/c7ra12072a

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…The chemical structures of nine isolated compounds were established (Figure 2) on the basis of 1 H, 13 C and 2D NMR (gDQCOSY, gHSQCAD, gHMBCAD) spectroscopic analysis and through the comparison of literature data. These compounds are as follows: a polyacetylene: lobetyolin (compound 1) [18]; an alcohol glycoside: calaliukiuenoside (compound 2) [19]; two phenylpropanoids: demethylsyrrigin (compound 3) and wahlenoside A (compound 4) [20]; two chlorogenic acid esters: chlorogenic acid methyl ester (compound 5) and chlorogenic acid butyl ester (compound 6) [21]; two flavonoids: nicotiflorin (compound 7) [22] and rutin (compound 8) [23]; and one megastigmane: corchoionoside A (compound 9) [24]. The structures of the isolates are given in Figure 2 and were elucidated based on 1D and 2D NMR spectral analyses (see Supplementary Materials Tables S1-S9 and Figures S1-S45).…”

Section: Resultsmentioning

confidence: 99%

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Phytochemical Analysis of the Aerial Parts of Campanula pelviformis Lam. (Campanulaceae): Documenting the Dietary Value of a Local Endemic Plant of Crete (Greece) Traditionally Used as Wild Edible Green

et al. 2023

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Native wild edible greens usually include plants with widespread geographical ranges and represent a long tradition associated with well-documented health effects, especially in the frame of the Mediterranean diet. Although consuming local endemic and range-restricted plants as wild edible greens is rare, in some areas of Crete this is a long ethnobotanical tradition. The present study is focused on the phytochemical and nutritional element analyses of the edible parts of the wild-growing green Campanula pelviformis. To date, nine secondary metabolites have been isolated: lobetyolin (1), calaliukiuenoside (2), demethylsyrrigin (3), wahlenoside A (4), chlorogenic acid methyl (5) and butyl ester (6), nicotiflorin (7), rutin (8) and corchoionoside A (9). This first-time research on the phytochemical composition of this local endemic plant of Crete is a basic step in attempts to document its nutritional value, also allowing an exploration of its beneficial properties. The nutritional value of the Mediterranean diet owes much to the inclusion of native edible wild plants, which are abundant in mineral elements and bioactive compounds known to promote human health. Among these plants, the local Cretan endemic species C. pelviformis stands out as a rare and valuable source of wild edibles with traditional dietary significance in eastern Crete. This plant’s rich content of mineral elements and bioactive compounds makes it an intriguing subject for further research into the potential health benefits of wild plant consumption.

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Section: Resultsmentioning

confidence: 99%

“…and C. liukiuensis Schltr. (Orchidaceae); it is known as "calaliukiuenoside" [18]. It has also been identified in Ginkgo biloba L. male flowers [45].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of the Aerial Parts of Campanula pelviformis Lam. (Campanulaceae): Documenting the Dietary Value of a Local Endemic Plant of Crete (Greece) Traditionally Used as Wild Edible Green

et al. 2023

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Flavonoids as biopesticides – Systematic assessment of sources, structures, activities and environmental fate

Schnarr

Segatto

Olsson

et al. 2022

Science of The Total Environment

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A Flavone-5-O-glycosyltransferase Obtained through Domain Shuffling and Its Application in the Bioproduction of Luteolin-5-O-glucoside

Lu,

Li,

Jia

et al. 2024

ACS Sustainable Chem. Eng.

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Luteolin-5-O-glucoside is a rare luteolin glycoside compound with enormous potential for application. In order to promote sustainability and a circular economy, environmentally friendly catalysts and catalytic processes are in demand to produce luteolin-5-O-glucoside. Using glycosyltransferase transformation is an efficient method for synthesizing glycosylated flavonoids. However, most reported glycosyltransferases have not been able to catalyze glycosylation on the 5-OH site, and a method for the sustainable production of luteolin-5-O-glucoside has not been established. In this paper, a glycosyltransferase DoUGT71A15 was cloned from Dichanthelium oligosanthes. The N-terminal fragment of ZmUGT707A8 (Met1−Met93) was inserted into the Nterminus of DoUGT71A15 by domain shuffling, and a biological catalyst ZmDo was obtained. ZmDo could convert luteolin to luteolin-5-O-glucoside with K m and k cat /K m values of 0.13 mM and 1355.8 s −1 •M −1 , respectively. Then, the catalytic mechanism of region selectivity of ZmDo was studied by using bioinformatics methods, and the key site E89 was identified through alanine scanning. Finally, the strain BSZ containing the UDPG circulatory system, which could use cellobiose as a substrate and recycle UDP to synthesize UDPG, was used for efficient production of luteolin-5-O-glucoside, with a yield of 2253 mg/L and a molar conversion rate of 95.8%. This research obtained a novel flavone-5-OH glycosyltransferase and produced luteolin-5-O-glucoside by bioconversion, which provided the possibility for sustainable production and application of luteolin-5-O-glucoside.

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Bio-guided isolation of plant growth regulators from allelopathic plant-Codonopsis pilosula: phyto-selective activities and mechanisms

Abstract: Bio-guided isolation of the aerial waste part of typical allelopathic plant-Codonopsis pilosulaled to six active compounds being produced.

Cited by 6 publications

References 36 publications

Phytochemical Analysis of the Aerial Parts of Campanula pelviformis Lam. (Campanulaceae): Documenting the Dietary Value of a Local Endemic Plant of Crete (Greece) Traditionally Used as Wild Edible Green

Phytochemical Analysis of the Aerial Parts of Campanula pelviformis Lam. (Campanulaceae): Documenting the Dietary Value of a Local Endemic Plant of Crete (Greece) Traditionally Used as Wild Edible Green

Flavonoids as biopesticides – Systematic assessment of sources, structures, activities and environmental fate

A Flavone-5-O-glycosyltransferase Obtained through Domain Shuffling and Its Application in the Bioproduction of Luteolin-5-O-glucoside

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