Bio-inspired, bioengineered and biomimetic drug delivery carriers

Yoo, Jin‐Wook; Irvine, Darrell J.; Discher, Dennis E.; Mitragotri, Samir

doi:10.1038/nrd3499

Cited by 1,114 publications

(796 citation statements)

References 158 publications

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“…Biological vesicles derived from microorganisms or human cells have also attracted much attention for in vivo delivery and hold promise for synthetic biology applications (89). One recent study focused on outer membrane vesicles (OMVs) that are naturally produced by Gram-negative bacteria (90).…”

Section: In Vivo Diagnosticsmentioning

confidence: 99%

Synthetic biology devices for in vitro and in vivo diagnostics

Slomovic

Pardee

Collins

2015

Proc. Natl. Acad. Sci. U.S.A.

301

228

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There is a growing need to enhance our capabilities in medical and environmental diagnostics. Synthetic biologists have begun to focus their biomolecular engineering approaches toward this goal, offering promising results that could lead to the development of new classes of inexpensive, rapidly deployable diagnostics. Many conventional diagnostics rely on antibody-based platforms that, although exquisitely sensitive, are slow and costly to generate and cannot readily confront rapidly emerging pathogens or be applied to orphan diseases. Synthetic biology, with its rational and short design-to-production cycles, has the potential to overcome many of these limitations. Synthetic biology devices, such as engineered gene circuits, bring new capabilities to molecular diagnostics, expanding the molecular detection palette, creating dynamic sensors, and untethering reactions from laboratory equipment. The field is also beginning to move toward in vivo diagnostics, which could provide near real-time surveillance of multiple pathological conditions. Here, we describe current efforts in synthetic biology, focusing on the translation of promising technologies into pragmatic diagnostic tools and platforms.synthetic biology | diagnostics | biosensing | synthetic gene networks | nanobiotechnology

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Section: In Vivo Diagnosticsmentioning

confidence: 99%

Synthetic biology devices for in vitro and in vivo diagnostics

Slomovic

Pardee

Collins

2015

Proc. Natl. Acad. Sci. U.S.A.

301

228

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“…[ 5 ] Biomimetic particles are now considered the REVIEW next generation of particles due to their specifi c design capable to mimic features from biological systems and surfaces. [ 6,7 ] Another example of the complexity of human body can be seen when a tissue is damaged. Many natural biomolecules diffuse into the required sites to trigger the adequate cell response in an attempt to restore the tissue homeostasis.…”

mentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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“…Another typical example of a natural self-assembling system is the viral capsid, which consists of protein subunits that self-assemble into a robust protein coating that protects the viral genome molecules and releases them at the correct moment by a gating mechanism 2 . Although viral vectors have been extensively investigated as promising drug delivery vehicles, their clinical applications have been limited owing to potential risks such as immune recognition and mutagenesis 3 . In the past decade, hierarchical self-assembly inspired by nature has evolved into an effective and practical strategy to fabricate supramolecular structures with transfer or delivery functions in medical applications.…”

mentioning

confidence: 99%

Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

et al. 2014

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The design of micro-or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances.

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Bio-inspired, bioengineered and biomimetic drug delivery carriers

Cited by 1,114 publications

References 158 publications

Synthetic biology devices for in vitro and in vivo diagnostics

Synthetic biology devices for in vitro and in vivo diagnostics

Design Advances in Particulate Systems for Biomedical Applications

Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

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