Bioinspired functionally graded approach is an innovative material technology, which has rapidly progressed both in terms of materials processing and computational modeling in recent years. Bioinspired functionally graded structure allows the integration of dissimilar materials without formation of severe internal stress and combines diverse properties into a single material system. It is a remarkable example of nature's ability to engineer functionally graded dental prostheses. Therefore, this novel technology is designed to improve the performance of the materials in medical and dental fields. Thus, this chapter book reviews the current status of the functionally graded dental prostheses and biomimetic process inspired by the human bone, enamel and dentin-enamel junction (DEJ) structures and the linear gradation in Young's modulus of the human bone, enamel and dentin-enamel junction, as a new material design approach, to improve the performance compared to traditional dental prostheses. Notable research is highlighted regarding application of biomimetic prostheses into various fields in dentistry. The current chapter book will open a new avenue for recent researches aimed at the further development of new dental prostheses for improving their clinical durability.