Bio-inspired hydrogel-based bandage with robust adhesive and antibacterial abilities for skin closure

Abstract

Although conventional suturing techniques are commonly used in assisting wound closure, they do pose limited conduciveness and may lead to secondary injury to wound tissues. Inspired by marine organism mussels, we designed and manufactured a bio-inspired hydrogel-based bandage with tough wet tissue adhesion to substitute traditional surgical suture, accelerate wound healing and avoid infection. Poly(γ-glutamic acid) was modified with 3,4-dihydroxyphenylalanine and glycidyl methacylate, then introduced into the acrylic acid- co -acrylamide hydrogel matrix with robust mechanical properties. The hydrogel bandage showed strong chemical linkage adhesion (70 ± 2.1 kPa), which is 2.8 times that of commercial tissue adhesive fibrin glue (25 ± 2.2 kPa). The hydrogel bandage can not only maintain the self-stability, but is also capable of self-tuning adhesive strength in the range of 14–70 kPa to achieve different adhesion effects by tuning constituent ratio. The bandage has desirable compression properties (0.7 ± 0.11 MPa) and tensile elongation (about 25 times), which ensures its resistance to damages, especially in joint spaces. Secondly, the bandage was endowed with antioxidant and endogenous broad-spectrum antibacterial properties with its catechol structure. Results also demonstrated excellent cell compatibility and blood compatibility, certifying its eligible biological safety profile. In a rat full-thickness cutaneous deficiency model, we can clearly observe that the bandage possesses the ability to promote wound healing (only need 6 days). Above all, this research provides a new strategy for the emergency treatment of liver hemostasis and myocardial repair during disaster rescue. Supplementary information Experimental details and supporting data are available in the online version of the paper10.1007/s40843-021-1724-8.

Conductive Hydrogel Patches with High Elasticity and Fatigue Resistance for Cardiac Microenvironment Remodeling

“…It is well known that acrylic/acrylamide-based gels are widely used in tissue engineering such as skin, heart, and muscle due to their excellent mechanical properties . In this study, Aa/Am was added to improve the mechanical properties of the biomaterials based on the active HA.…”

Gradient Microstructure Design in Stainless Steel: A Strategy for Uniting Strength-Ductility Synergy and Corrosion Resistance

“…At the plastic strain stage, the incompatibility in plastic stability between coarse-grains interior and nanostructured surface rises inter-layer constraint, and the strain partitioning between the recrystallized austenitic domain and the remained martensitic domain in nanostructured surface layer can activate intra-domain constraint [ 25 , 49 , 50 ]. These constraints lead to further accumulation of 3D hierarchical strain gradient, thereby promoting the development of both back stress in the softer layer/domain and forward stress in the harder layer/domain, and consequently causing extra hetero-deformation induced (HDI) hardening [ 23 , 41 ].…”

Bionic ordered structured hydrogels: structure types, design strategies, optimization mechanism of mechanical properties and applications

“…[220][221][222] However, the hydrogels prepared using bionic ordered structures can effectively enhance these properties, especially high strength and toughness. 223 Therefore, bionic ordered structured hydrogels can be used as excellent bioremediation materials for sutures, 39,224 bioadhesives, [225][226][227][228] wound dressing 162,[229][230][231] and implants.…”