Bio-inspired immobilization of metal oxides on monolithic microreactor for continuous Knoevenagel reaction

Song, Wentong; Shi, Da; Tao, Shengyang; Li, Zhao-Liang; Wang, Yuchao; Yu, Yingzhe; Qiu, Jieshan; Ji, Min; Wang, Xinkui

doi:10.1016/j.jcis.2016.07.052

Cited by 13 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reagents were streamed into the reactor at 0.05 mL min −1 (roughly 30 minutes residence time) at 80 °C, with compound 127 being obtained in 89% conversion. The apparatus could be operated for over 24 hours, however, leaching of Al 2 O 3 reduces the conversion to 76% [ 166 ].…”

Section: Reviewmentioning

confidence: 99%

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta¹,

Sharley²,

Baxendale³

2021

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the potential crossover between a multibillion dollar industry and the flourishing sub-field of flow chemistry evolving within the discipline of organic synthesis. This is illustrated through selected examples of industrially important transformations specific to the fragrances and flavours industry and by highlighting the advantages of conducting these transformations by using a flow approach. This review is designed to be a compendium of techniques and apparatus already published in the chemical and engineering literature which would constitute a known solution or inspiration for commonly encountered procedures in the manufacture of fragrance and flavour chemicals.

show abstract

Section: Reviewmentioning

confidence: 99%

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta¹,

Sharley²,

Baxendale³

2021

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

show abstract

“…41 Although heterogeneous organocatalysis in continuous-flow mode (also with silica supports) receives increased attention, [42][43][44] reports on the Knoevenagel reaction with fixed catalyst supports (porous-layer open-tubular design, monoliths, particulate beds) are relatively scarce. 16,17,[45][46][47][48][49][50][51][52][53] In both modes, however, the analysis of reaction products has so far almost exclusively been conducted off-line by gas chromatography.…”

Section: Heterogeneously Catalyzed Reactionmentioning

confidence: 99%

High-performance monoliths in heterogeneous catalysis with single-phase liquid flow

et al. 2017

View full text Add to dashboard Cite

Hierarchical, macro-mesoporous silica monoliths with domain sizes (sum of mean macropore size and skeleton thickness) of ∼1 μm are highly efficient supports in heterogeneous catalysis with single-phase liquid flow. Their unprecedented performance regarding low backmixing, the elimination of internal and external diffusive transport limitations, as well as the simultaneous realization of a large (internal and external) surface area of the monolith skeleton allow reactor operation under exclusive reaction control. For experimental characterization, the Knoevenagel condensation was employed with an aminopropylated silica monolith integrated into an on-line coupled, high-pressure reaction-analysis system. It allows precise, fully automated adjustment and control of all relevant reaction parameters and promises a boost in the rapid, reproducible determination of the intrinsic reaction kinetics, in general. Hydrodynamic and reaction kinetic parameters identify extreme plug-flow conditions with this high-surface-area, compact type of microreactor and quasi-homogeneous operation in continuous-flow mode.

show abstract

“…Each hole of the porous TCM was roughly equivalent to a microreactor [39]. Microreactor could provide excellent heat and mass transfer and shorter residence time [40].…”

Section: Comparison Of Conversion-per-pass and Multipass Conversionmentioning

confidence: 99%

A flow-through tubular catalytic membrane reactor using zirconium sulfate tetrahydrate-impregnated carbon membranes for acidified oil esterification

et al. 2017

Journal of the Energy Institute

View full text Add to dashboard Cite

Bio-inspired immobilization of metal oxides on monolithic microreactor for continuous Knoevenagel reaction

Cited by 13 publications

References 34 publications

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

High-performance monoliths in heterogeneous catalysis with single-phase liquid flow

A flow-through tubular catalytic membrane reactor using zirconium sulfate tetrahydrate-impregnated carbon membranes for acidified oil esterification

Contact Info

Product

Resources

About