Bio(inspired) strategies for the electro-sensing of β-lactam antibiotics

Bottari, Fabio; Blust, Ronny; Wael, Karolien De

doi:10.1016/j.coelec.2018.05.015

Cited by 18 publications

(11 citation statements)

References 49 publications

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“…The most widely used antibiotics in human and veterinary medicine are tetracyclines and β-lactams, particularly penicillins, sulfonamides, macrolides, and fluoroquinones [21,37]. Therefore, in our review, sensors developed for the detection of drugs belonging to these classes of antibiotics have been presented and discussed first.…”

Section: Recent Reports On Electrochemical Immunosensors Designatementioning

confidence: 99%

“…There are also reviews discussing the sensing of a particular class of antibiotics. Liu X. et al described different types of sensors developed for tetracyclines [36], while Bottari F. et al reviewed the electrochemical immunosensors that pertained to β-lactam antibiotics [37]. To the best of our knowledge there are no papers focused on electrochemical immunoassays used in the analysis of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Immunosensors for Antibiotic Detection

2019

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Antibiotics are an important class of drugs destined for treatment of bacterial diseases. Misuses and overuses of antibiotics observed over the last decade have led to global problems of bacterial resistance against antibiotics (ABR). One of the crucial actions taken towards limiting the spread of antibiotics and controlling this dangerous phenomenon is the sensitive and accurate determination of antibiotics residues in body fluids, food products, and animals, as well as monitoring their presence in the environment. Immunosensors, a group of biosensors, can be considered an attractive tool because of their simplicity, rapid action, low-cost analysis, and especially, the unique selectivity arising from harnessing the antigen–antibody interaction that is the basis of immunosensor functioning. Herein, we present the recent achievements in the field of electrochemical immunosensors designed to determination of antibiotics.

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Section: Recent Reports On Electrochemical Immunosensors Designatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Immunosensors for Antibiotic Detection

2019

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“…However, its unwise use has led to the dissemination of these compounds and corresponding metabolites in theecosystem 4 and food 5 (in particular of animal origin such as milk, 6‐9 meat, 10 fish, 11 and honey 12,13 ). This enhances the already worrying levels of bacterial resistance 14 . Consequently, antibiotic analysis becomes a pressing matter, not just in environmental samples but also in biological samples to optimize its clinical use 15‐17 …”

Section: Introductionmentioning

confidence: 99%

“…MIPs can be formed via different polymerization techniques, and, in the specific case of electroanalysis, electropolymerized MIPs (e‐MIPs) are the more common, 29 but heat‐assisted polymerization, while demanding more time and reagents, are still relevant 14,30,31 . This review aims to provide an overview of all the published works concerning antibiotic analysis making use of MIPs with an electroanalytical detection technique, regardless of how the MIP was prepared.…”

Section: Introductionmentioning

confidence: 99%

Employing molecularly imprinted polymers in the development of electroanalytical methodologies for antibiotic determination

Benachio

Lobato

Gonçalves

2020

J of Molecular Recognition

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Antibiotics, although being amazing compounds, need to be monitored in the environment and foodstuff. This is primarily to prevent the development of antibiotic resistance that may make them ineffective. Unsurprisingly, advances in analyticalsciences that can improve their determination are appreciated. Electrochemical techniques are known for their simplicity, sensitivity, portability and low‐cost; however, they are often not selective enough without recurring to a discriminating element like an antibody. Molecular imprinting technology aims to create artificial tissues mimicking antibodies named molecularly imprinted polymers (MIPs), these retain the advantages of selectivity but without the typical disadvantages of biological material, like limited shelf‐life and high cost. This manuscript aims to review all analytical methodologies for antibiotics, using MIPs, where the detection technique is electrochemical, like differential pulse voltammetry (DPV), square‐wave voltammetry (SWV) or electrochemical impedance spectroscopy (EIS). MIPs developed by electropolymerization (e‐MIPs) were applied in about 60 publications and patents found in the bibliographic search, while MIPs developed by other polymerization techniques, like temperature assisted (“bulk”) or photopolymerization, were limited to around 40. Published works covered the electroanalysis of a wide range of different antibiotics (β‐lactams, tetracyclines, quinolones, macrolides, aminoglycosides, among other), in a wide range of matrices (food, environmental and biological).

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“…It is critical to have quick, accurate and reliable sensors that can be brought into the field to be used by personnel without specialized training and provide analytical results in a time as short as possible. Attempts to address the first issue have been done by utilizing electrosensing 27 but require further optimization of the imprinted polymers that are used in conjunction 28 .…”

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confidence: 99%