Bio-inspired synthesis of hybrid tube-like structures based on CaCO<sub>3</sub> and type I-collagen

Tovani, Camila Bussola; Zancanela, Daniela C.; Faria, Amanda Natalina de; Ciancaglini, Pietro; Ramos, Ana Paula

doi:10.1039/c6ra18984a

Cited by 16 publications

(16 citation statements)

References 53 publications

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“…Tovani et al reported the synthesis of type-I collagen adsorbed on tube-like CCNPs of 100 nm, 200 nm, and 400 nm size. This complex was used for bone-tissue mimetic matrix formation to promote cell proliferation and as a filler to provide mechanical strength to organic scaffolds (Tovani et al 2016). Wei et al established a onepot synthesis of ~ 500 nm hollow spheres of vaterite.…”

Section: Precipitation Methodsmentioning

confidence: 99%

Calcium carbonate nano- and microparticles: synthesis methods and biological applications

et al. 2021

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Calcium carbonate micro-and nanoparticles are considered as chemically inert materials. Therefore, they are widely considered in the field of biosensing, drug delivery, and as filler material in plastic, paper, paint, sealant, and adhesive industries. The unusual properties of calcium carbonate-based nanomaterials, such as biocompatibility, high surface-to-volume ratio, robust nature, easy synthesis, and surface functionalization, and ability to exist in a variety of morphologies and polymorphs, make them an ideal candidate for both industrial and biomedical applications. Significant research efforts have been devoted for developing novel synthesis methods of calcium carbonate particles in micrometer and nanometer dimensions. This review highlights different approaches of the synthesis of calcium carbonate micro-and nanoparticles, such as precipitation, slow carbonation, emulsion, polymer-mediated method, including in-situ polymerization, mechano-chemical, microwave-assisted method, and biological methods. The applications of these versatile calcium carbonate micro-and nanoparticles in the biomedical field (such as in drug delivery, therapeutics, tissue engineering, antimicrobial activity, biosensing applications), in industries, and environmental sector has also been comprehensively covered.

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Section: Precipitation Methodsmentioning

confidence: 99%

Calcium carbonate nano- and microparticles: synthesis methods and biological applications

et al. 2021

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“…To visualize DNA, the sample was excited with the 488‐nm line of an Argon laser, and emission was collected between 499 and 541 nm. RNA was visualized by exciting the sample with the 458‐nm line of an Argon laser, and emission was collected between 642 and 682 nm . The samples were also analyzed on the 14th and 21st day of culture.…”

Section: Methodsmentioning

confidence: 99%

“…RNA was visualized by exciting the sample with the 458-nm line of an Argon laser, and emission was collected between 642 and 682 nm. 27,49 The samples were also analyzed on the 14th and 21st day of culture. The morphological analyses were taken in three samples, and the best images were selected.…”

Section: Morphology Attachment and Proliferation Of Cellsmentioning

confidence: 99%

Different compact hybrid Langmuir–Blodgett‐film coatings modify biomineralization and the ability of osteoblasts to grow

et al. 2018

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Calcium phosphates (CaPs) are biomaterials widely used in tissue regeneration with outstanding biological performance. Although the tremendous improvements achieved in CaP's materials research over the years, their interaction with physiological environments still need to be fully understood. The aim of this study is to explore a biomimetic Langmuir-Blodgett (LB) membrane to template the growth of hydroxyapatite (HAp) coatings on Ti surfaces and the ability of these coatings in inducing biomineralization by osteoblasts cultured in vitro. Changing the phospholipids (i.e., dihexadecyl phosphate (DHP) or octadecylphosphonic acid (OPA)), we also tuned the surface Ca concentration. This structural feature gave rise to different LB-hybrid surfaces where the concentration of Ca in the OPA/HAp was higher than the concentration of Ca in DHP/HAp coating. The higher Ca amount on OPA/HAp coatings, allied to the physical-chemical features, lead to different responses on osteoblasts, stimulating or inhibiting the natural biomineralization. The OPA/HAp coating caused a delay in the osteoblast proliferation as indicated by the decrease in the cell viability at the 7th culture day. Improved cell differentiation triggered by the DHP/HAp coating resulted in higher osteoblast biomineralization. The present data underscore that besides both coatings being composed by HAp, the final interfacial composition and physical-chemical properties influence differently the osteoblast behavior. Although the best osteoblast's viability was found to OPA/HAp, our dataset attested that DHP/HAp induced mineralization more effectively than that. This unexpected finding highlight the importance of deeply understanding the biomaterial interface and suggest a promising approach to the design of biofunctional LB-based coatings with tunable properties. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2524-2534, 2018.

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“…It has been shown that the unmodified single-and multi-walled toxicity of CNTs depends on concentration, these particles can be safely used in osteoblast cultures in lower concentrations [97]. The utilization of collagen-changed calcium carbonate nanotubes as another age of cylindrical structures for regeneration of bone has been reported [98]. Liposomes are synthetic vesicles from natural phospholipids with globular character.…”

Section: Carbon Nanotubes and Liposomesmentioning

confidence: 99%

Some Biological and Biomedical Effects of Nanoparticles

Hussein

Gamal

Arisha

2020

Zagazig Veterinary Journal

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Bio-inspired synthesis of hybrid tube-like structures based on CaCO₃ and type I-collagen

Abstract: Tube-like hybrid particles based on calcium carbonate, a biocompatible mineral, and collagen, enhance osteoblasts viability.

Cited by 16 publications

References 53 publications

Calcium carbonate nano- and microparticles: synthesis methods and biological applications

Calcium carbonate nano- and microparticles: synthesis methods and biological applications

Different compact hybrid Langmuir–Blodgett‐film coatings modify biomineralization and the ability of osteoblasts to grow

Some Biological and Biomedical Effects of Nanoparticles

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Bio-inspired synthesis of hybrid tube-like structures based on CaCO3 and type I-collagen

Abstract: Tube-like hybrid particles based on calcium carbonate, a biocompatible mineral, and collagen, enhance osteoblasts viability.

Cited by 16 publications

References 53 publications

Calcium carbonate nano- and microparticles: synthesis methods and biological applications

Calcium carbonate nano- and microparticles: synthesis methods and biological applications

Different compact hybrid Langmuir–Blodgett‐film coatings modify biomineralization and the ability of osteoblasts to grow

Some Biological and Biomedical Effects of Nanoparticles

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Resources

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Bio-inspired synthesis of hybrid tube-like structures based on CaCO₃ and type I-collagen