Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Quan, Wei-Yan; Li, Puwang; Wei, Jinsong; Jiang, Yuwei; Liang, Yingye; Zhang, Weilin; Chen, Qi-Zhou; Wu, Kefeng; Luo, Hui; Ouyang, Qianqian

doi:10.3390/biom12111601

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Other reports found that a peak at 1740 cm −1 is associated with ester groups of lubricant agents that can react with coupling agents used to improve the interaction between the PP matrix and lignocellulosic materials [35], indicating that these interactions diminish the mechanical behavior of composites. This is mainly due to the calcium ions interacting with components of sargassum, mainly alginate, forming interactions that allow sargassum to have an attraction with PP chains [34] and a possible increase in the mobility of polymer chains; there is not a chemical reaction between them. Other reports found that a peak at 1740 cm −1 is associated with ester groups of lubricant agents that can react with coupling agents used to improve the interaction between the PP matrix and lignocellulosic materials [35], indicating that these interactions diminish the mechanical behavior of composites.…”

Section: Characterization By Ftirmentioning

confidence: 99%

Novel PolyPropylene–Sargassum Particles Composites: Evaluation of Thermal and Thermomechanical Properties

Aragón-Vallejo,

Salazar-Cruz,

Chávez-Cinco

et al. 2023

J. Compos. Sci.

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Sargassum is a type of marine algae that has caused environmental problems in Mexico because it arrives in high quantities along the Mexican coast, especially in the Mexican Caribbean. This situation has become an environmental and economic problem, impacting tourism and other activities. As a result, it is reasonable to try to find an application for these algae. Recently, some applications in civil construction, cosmetics, and the food industry, among others, have been reported. The present work evaluates the thermal and structural properties of new polypropylene (PP)–Sargassum-based composites. Also, the effect of adding calcium stearate (CS) to increase the interaction between PP and Sargassum particles was investigated. PP–Sargassum particle composites were prepared by a melt mixing process, and the properties of these composites were evaluated using thermal techniques such as dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and infrared spectroscopy (FTIR). The DMA results showed that composites with low concentrations of Sargassum particles perform better than those with higher concentrations. When CS was added to composites, there was a significant improvement in storage modulus compared with composites without CS. This was attributed to the good adhesion of the particles to the matrix because the mobility of macromolecules increased in the presence of CS. The thermal stability of PP–Sargassum particle composites decreases when the amount of particles increases, and the addition of CS does not positively affect the thermal behavior of composites. The findings open the possibility of using Sargassum particles in new applications of these algae as a polymer additive to generate sustainable materials.

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Section: Characterization By Ftirmentioning

confidence: 99%

Novel PolyPropylene–Sargassum Particles Composites: Evaluation of Thermal and Thermomechanical Properties

Aragón-Vallejo,

Salazar-Cruz,

Chávez-Cinco

et al. 2023

J. Compos. Sci.

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“…The interest of polysaccharides is not limited to their rheological properties, the biological activities of some of them designate them as molecules capable of modifying the biological functions of certain organisms. Many studies have focused on the isolation and identification of polysaccharides and their biological activities [ 4 , 5 , 6 , 7 ]. However, the variety of raw materials and the mechanisms of polysaccharides differ.…”

Section: Introductionmentioning

confidence: 99%

“…Quan at al. [ 7 ] reported that polysaccharides act as bio-multifunctional wound dressings. There are many ways in which polysaccharides contribute to the healing of wounds.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

Aydi

Khadher

et al. 2023

Plants

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Phytochemical properties have recently increased the popularity of plant polysaccharides as wound dressing materials. This work aims at studying the structural characteristics of polysaccharides extracted from Moringa leaves (Moringa Leaves Water Soluble Polysaccharide: MLWSP), and its antioxidant activities, cytotoxic effects, and laser burn wound healing effects in rats. This MLWSP was structurally characterized. Results showed 175.21 KDa and 18.6%, respectively, for the molecular weight and the yield of the novel extracted polysaccharide. It is a hetero-polysaccharide containing arabinose, rhamnose, and galactose. XRD suggested a semi-crystalline structure of the studied polymer and FT-IR results revealed a typical polysaccharide structure. It is composed of 50 to 500 µm rocky-shaped units with rough surfaces and it was found to inhibit the proliferation of the human colon (HCT-116) (IC50 = 36 ± 2.5 µg/mL), breast (MCF-7) (IC50 = 48 ± 3.2), and ovary cancers (IC50 = 24 ± 8.1). The MLWSP showed significant antioxidant effects compared to Trolox (CI50 = 0.001 mg/g). Moreover, promising wound healing results were displayed. The effect of MLWSP hydrogel application on laser burn injuries stimulated wound contraction, re-epithelization, and remodeling phases 8 days after treatment. The wound healing potential of MLWSP may be due to its significant antioxidant activity and/or the huge amount of monosaccharide molecules.

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Designing, Optimising, and Assessing a Novel Emulgel Containing Minoxidil for Controlled Drug Release, Incorporating Marine-based Polymers

Mathew,

Saral

2025

CDD

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Objective:: This study aimed to develop an emulgel containing minoxidil as a drug for hair growth promotion in diseases, such as androgenetic alopecia, using gelling agents, such as chitosan and fucoidan. Methods:: In this study, gelling agents were selected for the emulgel formulation. By various evaluation tests and through optimization, the chitosan-fucoidan combination was selected as the gelling agent for the preparation of emulgel using various evaluation parameters. Results:: X2, the best emulgel formulation, contained 2.54 % chitosan and 0.896 % fucoidan. Chitosan prolonged the duration of drug release, and controlled release was obtained. Fucoidan increased the gelling activity, water absorption rate, and stability of the formulation. In this study, the X2 formulation showed the highest percentage of drug release at the 12th hour. It was found to be 99.7%, which followed the zero-order release model. Conclusion:: Owing to the wide range of biological activities of fucoidan, the loaded active substance can be protected, and at the same time, its potency can be improved, resulting in effective treatment. Because fucoidan has diverse properties and potential, it will be widely used in the biomedical and pharmaceutical industries in the future.

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Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Cited by 3 publications

References 33 publications

Novel PolyPropylene–Sargassum Particles Composites: Evaluation of Thermal and Thermomechanical Properties

Novel PolyPropylene–Sargassum Particles Composites: Evaluation of Thermal and Thermomechanical Properties

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

Designing, Optimising, and Assessing a Novel Emulgel Containing Minoxidil for Controlled Drug Release, Incorporating Marine-based Polymers

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