Bio-nanobactericides: an emanating class of nanoparticles towards combating multi-drug resistant pathogens

Abstract

The recent research on nanomaterials as antibacterials agents have gained significant importance in recent decades. The sustainable development of bio-nanobactericides from biogenic sources have resulted as one of the potent bactericidal agents at nanoscale. Bio-nanobactericides generously offers low toxic profiles in comparison with nanomaterials synthesized from conventional routes. The biological components mediate the synthesis and act as stabilizing agent to participate in the desired activity. These nanobactericides offers efficient alternatives to combat drug resistant pathogens with their unique mode of actions. Owing to their size dependent properties, they can be one of the most attractive tools against both gram +ve and gram −ve pathogens which are resistant to most of the available antibiotics. Based on these keys fundamental facts and considerations, the present mini review is designed to compile the recently published studies on nanomaterials bearing antibacterial activity against clinically important test pathogens.

Nanoparticulate Antibiotic Systems as Antibacterial Agents and Antibiotic Delivery Platforms to Fight Infections

“…Among the metal oxide nanoparticles, ZnONPs have attracted attention thanks to their optical, physical, and antimicrobial properties. Indeed, ZnONPs are extremely interesting nanomaterials for various industrial applications such as in optical communications and in the manufacturing of rubber, paint, coating, lubricants, and cement, to name a few [109], but also for biological applications especially in anticancer and antibacterial fields [110]. It is legitimate to think that if zinc oxide has good antibacterial properties, nanosize-ZnO, with its large surface area-to-volume ratio, is a better antibacterial compared to its bulk counterpart.…”