Bio-repository of DNA in stroke: a study protocol of three ancestral populations

Cotlarciuc, Ioana; Khan, Muhammad Saleem; Maheshwari, Ankita; Yadav, Sunaina; Khan, Fahmi Yousef; Al-Hail, Hassan; Silva, Ranil de; Gorthi, Sankar Prasad; Gupta, Salil; Sharma, Shailesh; Sylaja, PN; Prasad, Kameshwar; Sharma, Pankaj

doi:10.1258/cvd.2012.012019

Cited by 10 publications

(13 citation statements)

References 28 publications

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“…In this paper, we will review stroke in Qatar making reference to published epidemiological data regarding the dynamics of Qatar’s stroke burden. We will include native Qatari and migrant South Asian data (1188 cases, age range 16–89 years) from the ongoing, multinational Bio-Repository of DNA in Stroke (BRAINS) 15,16 where relevant, in order to give an up-to-date representation of stroke in Qatar.…”

Section: Introductionmentioning

confidence: 99%

Current status of stroke in Qatar: Including data from the BRAINS study

Jallow

Hail

Han

et al. 2019

JRSM Cardiovascular Disease

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Background Qatar is located on the north-eastern coast of the Arabian Peninsula. Qatari natives account for less than 15% of the population while the largest migrant group comprising 60% derives from South Asia. Despite projections that stroke burden in Qatar will increase with population ageing, epidemiological studies focusing on stroke in Qatar are relatively scarce. Method We reviewed the available epidemiological publications relating to Qatar. In addition, we have added to this knowledge by incorporating Qatari data from the on-going Bio-Repository of DNA in Stroke, an independent multinational database of stroke patients. Results Qatar has low reported incidence and mortality rates of 58 and 9.17 per 100,000 per year, respectively, which may be explained by its middle-aged migrant worker majority population. Correspondingly, South Asian migrants in Qatar suffered younger strokes than Qatari natives (48.7 vs 63.4 years, P < 0.001). Among the most common risk factors identified in stroke patients were hypertension (77.9%), diabetes (43.8%) and hypercholesterolemia (28.5%). Ischaemic stroke was the most frequent subtype amongst migrant South Asians (71.1%). The majority of stroke cases had computed tomography and/or magnetic resonance imaging scans, but only 11.1% of ischaemic strokes were thrombolysed. Qataris on one-year follow up were more often found to have died (6.5% vs 0.3%) and had further stroke/transient ischaemic attack events (17.4% vs 6.4%, P = 0.009) compared to South Asians. Conclusion The burden of stroke is increasing in Qatar, and considerable disparities are observed between the native and migrant populations which likely will require different approaches to management by its healthcare system.

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Section: Introductionmentioning

confidence: 99%

Current status of stroke in Qatar: Including data from the BRAINS study

Jallow

Hail

Han

et al. 2019

JRSM Cardiovascular Disease

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“…The stroke population included 8,624 cases and 12,722 controls from 7 different cohorts (see Supplemental Material): Australian Stroke Genetics Collaborative (ASGC) 13, 14 , Bio-Repository of DNA in Stroke (BRAINS) 15, 16 , Genetics of Early Onset Stroke (GEOS) 17, 18 , Ischemic Stroke Genetics Study and Siblings with Ischemic Stroke Study (ISGS 19 / SWISS 20 ), Welcome Trust Case Control Consortium 2 United Kingdom (WTCCC2-UK) 21 , Welcome Trust Case Control Consortium 2 Germany (WTCCC2-Germany) 21 and Vitamin Intervention for Stroke Prevention trial (VISP) 22 .All participating cohorts received institutional ethical clearance and signed consent from each participating study subject. ISGS/SWISS, GEOS and VISP used gender and age matched stroke-free controls recruited from the local population.…”

Section: Methodsmentioning

confidence: 99%

Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke

Yadav

Cotlarciuc

Munroe

et al. 2013

Stroke

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Background and Purpose Visit-to-visit variability in BP is associated with ischemic stroke. We sought to determine whether such variability has a genetic aetiology and whether genetic variants associated with BP variability are also associated with ischemic stroke. Methods A GWAS for loci influencing BP variability was undertaken in 3,802 individuals from the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT) study where long-term visit-to-visit and within visit BP measures were available. Since BP variability is strongly associated with ischemic stroke, we genotyped the sentinel SNP in an independent ischemic stroke population comprising of 8,624 cases and 12,722 controls and in 3,900 additional (Scandinavian) participants from the ASCOT study in order to replicate our findings. Results The ASCOT discovery GWAS identified a cluster of 17 correlated SNPs within the NLGN1 gene (3q26.31) associated with BP variability. The strongest association was with rs976683 (p=1.4×10−8). Conditional analysis on rs976683 provided no evidence of additional independent associations at the locus. Analysis of rs976683 in ischemic stroke patients found no association for overall stroke (OR 1.02; 95% CI 0.97-1.07; p=0.52) or its sub-types: CE (OR 1.07; 95% CI 0.97-1.16; p=0.17), LVD (OR 0.98; 95% 0.89-1.07; p=0.60) and SVD (OR 1.07; 95% CI 0.97-1.17; p=0.19). No evidence for association was found between rs976683 and BP variability in the additional (Scandinavian) ASCOT participants (p=0.18). Conclusions We identified a cluster of SNPs at the NLGN1 locus showing significant association with BP variability. Follow up analyses did not support an association with risk of ischemic stroke and its subtypes.

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“…In this regard, the UK Biobank (European and British Asian), Brains-SA (India and Sri Lanka), Bio-Repository of DNA in StrokeMiddle East (Qatar) 21 , China Kadoorie Biobank 22 and other collaborative initiatives, such as the International Stroke Genetics Consortium, have contributed to the identification of several loci associated with IS subtypes. Genome-wide association study approaches have been adopted for investigating many complex diseases, such as stroke, and have been effective in identifying new genetic variants associated with the risk of disease.…”

Section: Discussionmentioning

confidence: 99%

Joinville stroke biobank: study protocol and first year’s results

Ferreira¹,

França²,

Nagel³

et al. 2017

Arq. Neuro-Psiquiatr.

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Aiming to contribute to studies that use detailed clinical and genomic information of biobanks, we present the initial results of the first Latin American Stroke Biobank. Methods: Blood samples were collected from patients included in the Joinville Stroke Registry and four Brazilian cities. Demographic socio-economic data, cardiovascular risk factors, Causative Classification System for Ischemic Stroke, Trial of Org 10172 in Acute Stroke Treatment and National Institutes of Health scores, functional stroke status (modified Rankin) and brain images were recorded. Additionally, controls from both geographic regions were recruited. High-molecular-weight genomic DNA was obtained from all participants. Results: A total of 2,688 patients and 3,282 controls were included. Among the patients, 76% had ischemic stroke, 12% transient ischemic attacks, 9% hemorrhagic stroke and 3% subarachnoid hemorrhage. Patients with undetermined ischemic stroke were most common according the Trial of Org 10172 in Acute Stroke Treatment (40%) and Causative Classification System for Ischemic Stroke (47%) criteria. A quarter of the patients were under 55 years of age at the first-ever episode. Conclusions: We established the Joinville Stroke Biobank and discuss its potential for contributing to the understanding of the risk factors leading to stroke.

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Bio-repository of DNA in stroke: a study protocol of three ancestral populations

Cited by 10 publications

References 28 publications

Current status of stroke in Qatar: Including data from the BRAINS study

Current status of stroke in Qatar: Including data from the BRAINS study

Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke

Joinville stroke biobank: study protocol and first year’s results

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