Bioabsorbable scaffolds for guided bone regeneration and generation

Kellomäki, Minna; Niiranen, Henna; Puumanen, K.; Ashammakhi, Nureddin; Waris, Timo; Törmälä, Pertti

doi:10.1016/s0142-9612(00)00117-4

Cited by 207 publications

(122 citation statements)

References 47 publications

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“…An adequate resorbing material for oral procedures should allow cell adhesion, proliferation and migration in order to prevent exposure to oral microorganisms (17,18). Collagen is one of the most researched resorbing materials, being the main component of the periodontal connective tissue matrix, with significant hemostatic properties, thus aiding in early stabilization of the surgical wound.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

et al. 2015

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Mucograft® is a resorbing porcine matrix composed of type I and type III collagen, used for soft tissue augmentation in guided tissue bony regeneration procedures. This in vitro study aimed to evaluate the biological behavior of Mucograft® in human gingival fibroblasts, as well as the ability of the matrix to induce production of extracellular matrix. Six resorbing Mucograft® matrices (MCG) were cut into 3 x 2 mm rectangles and 5 x 5 mm squares and were placed in 96-and 24-well plates, respectively. The control group (CTRL) consisted of cells plated on polystyrene without the MCG. After one, two, three and seven days, cell proliferation and viability were assessed using the Trypan exclusion method and MTT test, respectively. Type III collagen (COL 3A1) and vimentin (VIM) expression were also evaluated at 10 and 14 days, using Western blotting. Statistical analysis, using ANOVA with post hoc Bonferroni test, revealed that human gingival fibroblasts from MCG showed similar results (p>0.05) for proliferation and viability as the cells cultured on CTRL. After 14 days, a significant decrease in COL 3A1 expression (p<0.05) was observed when cultured with the MCG. VIM expression showed no significant difference at any time period (p>0.05). Although no increase in extracellular matrix secretion was observed in this in vitro study, Mucograft® presented cellular compatibility, being an option for a scaffold whenever it is required.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

et al. 2015

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“…A suitable temporary scaffold material exhibiting adequate mechanical and biological properties is required to enable tissue regeneration by exploiting the body's inherent repair mechanisms, i.e. a regenerative allograft [2]. Numerous bioresorbable materials have been investigated as scaffolds for tissue engineering and tissue repair, including naturally occurring [3,4] and synthetic polymers [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

et al. 2002

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Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering.

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“…The excellent biocompatibility of e-PTFE * Corresponding author. E-mail address: darmawan_p3tir@batan.go.id membranes has been confirmed by many studies, but it must be removed by a second surgical procedure, possible causing undesirable bone resorption, increases the risk of patient infection and other undesirable side effects [5,6]. Bioabsorbable membranes have been studied for similar kinds of indications as for PTFE membranes.…”

Section: Introduction * * * *mentioning

confidence: 99%

“…Polyglycolide (PGA) is probably the most frequently studied bioabsorbable membrane. It has been studied in animal models, in cell culture experiments and even in clinical use [6]. Another absorbable membranes such as alginate, polylactic acid, polygalactin, and collagen were also been introduced for application in GBR procedure [1,3,7].…”

Section: Introduction * * * *mentioning

confidence: 99%

In-vitro Degradation Behaviour of Irradiated Bacterial Cellulose Membrane

et al. 2013

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Bacterial cellulose membrane synthesized by Acetobacter xylinum in coconut water medium has potential application for Guided bone Regeneration. However, this membrane may not meet some application requirements due to its low biodegradation properties. In this paper, incorporation of gamma irradiation into the membrane is a developed strategy to increase its biodegradability properties. The in-vitro degradation study in synthetic body fluid (SBF) of the irradiated membrane has been analyzed during periods of 6 months by means of weight loss, mechanical properties and scanning electron microscopy observation compared to that the un-irradiated one. The result showed that weight loss of irradiated membrane with 25 kGy and 50 kGy and immersed in SBF solution for 6 months reached 18% and 25% respectively. While un-irradiated membrane did not give significant weight loss. Tensile strength of membranes decreases with increasing of irradiation dose and further decreases in tensile strength is observed when irradiated membrane was followed by immersion in SBF solution. Microscope electron image of cellulose membranes shows that un-irradiated bacterial cellulose membrane consists of dense ultrafine fibril network structures, while irradiation result in cleavage of fibrils network of cellulose. The fibrils network become loosely after irradiated membrane immersed in SBF solution due to released of small molecular weight carbohydrates formed during by irradiation from the structure.

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Bioabsorbable scaffolds for guided bone regeneration and generation

Cited by 207 publications

References 47 publications

Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

In-vitro Degradation Behaviour of Irradiated Bacterial Cellulose Membrane

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