Bioabsorbable thread for tight tying of bones

Hattori, Koji; Tomita, Naohide; Tamai, Susumu; Ikada, Yoshito

doi:10.1007/s007760050009

Cited by 17 publications

(12 citation statements)

References 12 publications

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“…Poly-caprolactone PCL, a material initially developed as a bioabsorbable thread for bone sutures (Hattori et al 2000) and composites containing PCL have been successfully used for the production of fibrous scaffolds in cartilage, bone, and soft tissue engineering. A PCL nanofibrous scaffold composed of electrospun nanofibers has been shown to maintain chondrocytes in a mature functional state (Li et al 2005b).…”

Section: Synthetic Polymersmentioning

confidence: 99%

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

et al. 2009

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The ultimate goal in the design of biomimetic materials for use in tissue engineering as permanent or resorbable tissue implants is to generate biocompatible scaffolds with appropriate biomechanical and chemical properties to allow the adhesion, ingrowth, and survival of cells. Recent efforts have therefore focused on the construction and modification of biomimetic surfaces targeted to support tissue-specific cell functions including adhesion, growth, differentiation, motility, and the expression of tissue-specific genes. Four decades of extensive research on the structure and biological influence of the extracellular matrix (ECM) on cell behavior and cell fate have shown that three types of information from the ECM are relevant for the design of biomimetic surfaces: (1) physical properties (elasticity, stiffness, resilience of the cellular environment), (2) specific chemical signals from peptide epitopes contained in a wide variety of extracellular matrix molecules, and (3) the nanoscale topography of microenvironmental adhesive sites. Initial physical and chemical approaches aimed at improving the adhesiveness of biomaterial surfaces by sandblasting, particle coating, or etching have been supplemented by attempts to increase the bioactivity of biomaterials by coating them with ECM macromolecules, such as fibronectin, elastin, laminin, and collagens, or their integrin-binding epitopes including RGD, YIGSR, and GFOGER. Recently, the development of new nanotechnologies such as photo- or electron-beam nanolithography, polymer demixing, nano-imprinting, compression molding, or the generation of TiO(2) nanotubes of defined diameters (15-200 nm), has opened up the possibility of constructing biomimetic surfaces with a defined nanopattern, eliciting tissue-specific cellular responses by stimulating integrin clustering. This development has provided new input into the design of novel biomaterials. The new technologies allowing the construction of a geometrically defined microenvironment for cells at the nanoscale should facilitate the investigation of nanotopography-dependent mechanisms of integrin-mediated cell signaling.

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Section: Synthetic Polymersmentioning

confidence: 99%

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

et al. 2009

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“…Each of these models consists of separate cells of the periosteum, cartilage, and tendon obtained from bovine sources. The cells are seeded individually onto biodegradable polymer scaffolds of PGA [8,9] or copolymers of PGA and PLLA [8,9] or PCL [10] and PLLA. The scaffolds serve to support the growth and subsequent development of respective osteoblasts, chondrocytes, or tenocytes.…”

mentioning

confidence: 99%

The potential of tissue engineering in orthopedics

Landis

Jacquet

Hillyer

et al. 2005

Orthopedic Clinics of North America

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“…16 Our polymer, on the other hand, seems to be safer than SIS, because the safety of the material has already been established based on the clinical experience with a suture thread made from it. 17 Our Fig. 6.…”

Section: Discussionmentioning

confidence: 96%