Bioabsorption qualities of chitosan-absorbable vascular templates

Haque, Mohamad; Beekley, Alec C.; Gutowska, Anna; Reardon, Ruth Ann; Groo, Paul; Murray, Sean P.; Andersen, Charles A.; Azarow, Kenneth S.

doi:10.1016/s0149-7944(00)00422-0

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…One study has even shown that chitosan may produce an immune response when left in the body, which would make it inappropriate for internal use. 13 As such, we chose to perform a similar modification to a different biopolymer, alginate, which has a better basis for internal use. This natural polysaccharide has been successfully used internally in FDA approved bioabsorbable products such as PROGENIX TM (a 4 putty-like mixture of alginate and collagen containing demineralization bone particles used as a bone graft substitute) and FOREseal TM (a staple-line reinforcement sleeve to create airtight closure of during lung resection procedures).…”

Section: Introductionmentioning

confidence: 99%

Determination of efficacy of a novel alginate dressing in a lethal arterial injury model in swine

Dowling¹,

Chaturvedi²,

MacIntire³

et al. 2016

Injury

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Hm-alginate demonstrates a greatly superior efficacy, relative to unmodified alginate and Kerlix™ gauze dressings, in achieving hemostasis from a lethal femoral artery puncture in swine. This is a similar result as has been previously described when performing hydrophobic modification to chitosan. The current study further suggests that hydrophobic modification of a hydrophilic biopolymer backbone can significantly increase the hemostatic capabilities relative to the native biopolymer.

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Section: Introductionmentioning

confidence: 99%

Determination of efficacy of a novel alginate dressing in a lethal arterial injury model in swine

Dowling¹,

Chaturvedi²,

MacIntire³

et al. 2016

Injury

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show abstract

“…Concurrent with interest in the area of regenerative medicine, interest in the use of chitosan as an implant material has been growing. 1,2 In vivo, purified chitosan elicits a low foreign body response, and porous chitosan implants generally stimulate rapid tissue ingrowth and integration. [3][4][5][6] Under hydrated conditions, chitosan materials are effectively dense hydrogels containing up to 60 wt % water.…”

Section: Introductionmentioning

confidence: 99%

Branched chitosans: Effects of branching parameters on rheological and mechanical properties

Aggarwal

Matthew

2007

J Biomedical Materials Res

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Chitosan continues to be studied as a promising biomaterial for tissue repair and regeneration applications. However, chitosan structures show a large reduction in tensile strength in the wet state. Methods for improving the wet strength of chitosan materials may broaden its applicability as a tissue scaffold for applications requiring significant load bearing capacity. In this study, the role of molecular architecture in defining the mechanical properties of hydrated chitosan membranes was examined. Specifically, branched chitosan molecules were synthesized with a range of branch lengths and branch densities. Physical and mechanical properties were characterized using viscometry, FTIR spectroscopy, and tensile testing measurements, and the results were correlated with the postulated architecture of the linear and branched chitosan materials. Both branch density and branch length were found to influence the mechanical properties of chitosan membranes. For example, high-molecular-weight (600 kDa) chitosans grafted with 80 kDa branches exhibited up to twofold increases in both tensile strength and extensibility. FTIR results indicated that these increases correlated with enhanced levels of hydrogen bonding in the branched materials. Vascular smooth muscle cells cultured on cast membranes of the branched chitosans exhibited no differences in adhesion or spreading as compared to the linear polymer. The results indicate that the mechanical properties of chitosan materials can be improved by the induction of a branched molecular architecture.

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Complex Microstructured 3D Surfaces Using Chitosan Biopolymer

Fernandez

Mills

Samitier

2009

Small

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A technique for producing micrometer-scale structures over large, nonplanar chitosan surfaces is described. The technique makes use of the rheological characteristics (deformability) of the chitosan to create freestanding, three-dimensional scaffolds with controlled shapes, incorporating defined microtopography. The results of an investigation into the technical limits of molding different combinations of shapes and microtopographies are presented, highlighting the versatility of the technique when used irrespectively with inorganic or delicate organic moulds. The final, replicated scaffolds presented here are patterned with arrays of one-micrometer-tall microstructures over large areas. Structural integrity is characterized by the measurement of structural degradation. Human umbilical vein endothelial cells cultured on a tubular scaffold show that early cell growth is conditioned by the microtopography and indicate possible uses for the structures in biomedical applications. For those applications requiring improved chemical and mechanical resistance, the structures can be replicated in poly(dimethyl siloxane).

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Bioabsorption qualities of chitosan-absorbable vascular templates

Cited by 6 publications

References 5 publications

Determination of efficacy of a novel alginate dressing in a lethal arterial injury model in swine

Determination of efficacy of a novel alginate dressing in a lethal arterial injury model in swine

Branched chitosans: Effects of branching parameters on rheological and mechanical properties

Complex Microstructured 3D Surfaces Using Chitosan Biopolymer

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