Determination of efficacy of a novel alginate dressing in a lethal arterial injury model in swine

Dowling, Matthew B.; Chaturvedi, Apurva; MacIntire, Ian C.; Javvaji, Vishal; Gustin, John P.; Raghavan, Srinivasa R.; Scalea, Thomas M.; Narayan, Mayur

doi:10.1016/j.injury.2016.05.003

Cited by 28 publications

(19 citation statements)

References 15 publications

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“…On account of the high reactive amine groups within the chitosan backbone, CS is easily modified for improving the hemostatic efficacy (Yang et al, 2018). Dowling et al (2016) synthesized the dodecyl-modified chitosan (HM-CS) via reacting with the amino groups. Dodecyl-modified chitosan was made into the self-expanding foam with a sprayed behavior from a gas tank.…”

Section: Chitosanmentioning

confidence: 99%

“…In 2008, safety, efficacy, usability, cost, and Food and Drug Administration (FDA) approval are required as five main necessities for use all over the world ( Spotnitz and Burks, 2008 , 2010 ), and other specific requirements like biodegradability, biocompatibility, mechanics, swelling ratio, stability, qualified water tightness, adjustable adhesion, and enhanced ability of healing process through the delivery of growth factors or active drugs are also be focused for actual usage. Accordingly, ideal hemostatic agents should simultaneously have abilities with rapid hemostasis, good biocompatibility, well-matched degradation, no adverse effects on wound healing and conducive to accelerating the healing process ( Howe and Cherpelis, 2013 ; Qin et al, 2015 ; Dowling et al, 2016 ; Momeni and Filiaggi, 2016 ). Furthermore, the important issues of quality, manufacturing cost, stability, swelling rate, safety and adjustable mechanics should also be considered and addressed ( Hsu et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Chen

Wang

et al. 2020

Front. Bioeng. Biotechnol.

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Rapid hemostasis and formation of stable blood clots are very important to prevent massive blood loss from the excessive bleeding for living body, but their own clotting process cannot be completed in time for effective hemostasis without the help of hemostatic materials. In general, traditionally suturing and stapling techniques for wound closure are prone to cause the additional damages to the tissues, activated inflammatory responses, short usage periods and inevitable second operations in clinical applications. Especially for the large wounds that require the urgent closure of fluids or gases, these conventional closure methods are far from enough. To address these problems, various tissue adhesives, sealants and hemostatic materials are placed great expectation. In this review, we focused on the development of two main categories of tissue adhesive materials: synthetic polymeric adhesives and naturally derived polysaccharide adhesives. Research of the high performance of hemostatic adhesives with strong adhesion, better biocompatibility, easy usability and cheap price is highly demanded for both scientists and clinicians, and this review is also intended to provide a comprehensive summarization and inspiration for pursuit of more advanced hemostatic adhesives for biological fields.

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Section: Chitosanmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Chen

Wang

et al. 2020

Front. Bioeng. Biotechnol.

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“…Alginate is a natural polymer extracted from brown seaweed and it has been extensively used in biomedical applications [61]. Although biocompatible, alginate shows low hemostatic performance [62]. Combining alginate with collagen, the most abundant protein in the human body and a major component of extracellular matrix, attempted to increase hemostatic function and promote cell proliferation.…”

Section: Wound Healingmentioning

confidence: 99%

From Dermal Patch to Implants—Applications of Biocomposites in Living Tissues

2020

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Composites are composed of two or more materials, displaying enhanced performance and superior mechanical properties when compared to their individual components. The use of biocompatible materials has created a new category of biocomposites. Biocomposites can be applied to living tissues due to low toxicity, biodegradability and high biocompatibility. This review summarizes recent applications of biocomposite materials in the field of biomedical engineering, focusing on four areas-bone regeneration, orthopedic/dental implants, wound healing and tissue engineering.

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“…Death from hemorrhage represents more than 60,000 deaths per year in the United States and 1.9 million deaths worldwide with 1.4 million of which result from physical trauma (Lozano et al, 2012). Hemorrhage is the leading cause of cardiac arrest from trauma in both civilian and military sectors (Dowling et al, 2016;Eastridge et al, 2012;Kelly et al, 2008;Lozano et al, 2012;. Hemorrhage can lead to hypovolemic shock and subsequent cardiac arrest.…”

Section: Need For Studymentioning

confidence: 99%

Effects of Endotracheal Administration of Epinephrine in Cardiac Arrest of Adult and Pediatric Swine

Kertes¹,

Fillman²,

Krawczyk³

et al. 2019

MSHP

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BACKGROUND: Few studies have investigated the effects of hypovolemia on area under the curve (AUC) and the return of spontaneous circulation (ROSC) comparing adults and children in cardiac arrest.AIMS: To compare the epinephrine endotracheal (ET) administration relative to AUC, rate, time to, and odds of achieving ROSC between hypovolemic adult and pediatric cardiac arrest models.METHODS: This was an experimental study using male Adult ET and Pediatric ET swine. Pediatric ET pigs (N=7) weighed 20-30 kg representing the average weight for a child between 5 and 6 years of age. Adult ET pigs (N=7) weighed 60 to 80 kg. All were exsanguinated 35% of their blood volume. Swine were put into arrest for 2 minutes. Cardiopulmonary resuscitation (CPR) was initiated for 2 minutes; epinephrine was then administered. Blood samples were collected over 5 minutes. RESULTS: No significant difference occurred in AUC between the groups (p > 0.05). The Pediatric ET group had higher rates of ROSC and a shorter time to ROSC (p < 0.05). Pediatric ET group had a 15 times greater odds of achieving ROSC compared to the Adult ET group. CONCLUSION: Based on the results of this study, we recommend epinephrine administration via ET within the pediatric arrest model, but not for the adult.

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Determination of efficacy of a novel alginate dressing in a lethal arterial injury model in swine

Cited by 28 publications

References 15 publications

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

From Dermal Patch to Implants—Applications of Biocomposites in Living Tissues

Effects of Endotracheal Administration of Epinephrine in Cardiac Arrest of Adult and Pediatric Swine

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