Bioaccumulation and oxidative stress responses measured in the estuarine ragworm (Nereis diversicolor) exposed to dissolved, nano- and bulk-sized silver

Cozzari, Margherita; Elia, Antonia Concetta; Pacini, Nicole; Smith, Brian D.; Boyle, David; Rainbow, Philip S.; Khan, Farhan R.

doi:10.1016/j.envpol.2014.12.015

Cited by 45 publications

(28 citation statements)

References 45 publications

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“…Higher total Ag concentrations for AgNPs in S7 should have been used to confirm this result; nevertheless, because the concentration was already unrealistically high from an environmental point of view, this was not considered relevant. We cannot rule out the possibility of NP-specific toxicity observed in earlier studies, if more sensitive endpoints were used (Chan and Chiu 2015;Cozzari et al 2015;Park et al 2015). Nonetheless, the environmental relevance of the possible NP-specific toxicity was considered low because L. variegatus tolerated extreme concentrations of AgNPs in S7.…”

Section: Toxicity Of Agno 3 and Agnpsmentioning

confidence: 94%

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Toxicity of silver nanoparticles to Lumbriculus variegatus is a function of dissolved silver and promoted by low sediment pH

Rajala¹,

Vehniäinen²,

Väisänen³

et al. 2018

Enviro Toxic and Chemistry

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Toxicity of silver nanoparticles (AgNPs) to benthic organisms is a major concern. The use of AgNPs in industry and consumer products leads to increasing release of AgNPs into the aquatic environment-sediments being the major sink. Effects of sediment pH on the toxicity of AgNPs to benthic oligochaeta Lumbriculus variegatus were studied in a 23-d toxicity test. Artificially prepared sediments (pH 5 and 7) were spiked with varying concentrations of uncoated AgNP, polyvinylpyrrolidone (PVP)-coated AgNP, and silver nitrate (AgNO ) as dissolved Ag reference. Number of individuals and biomass change were used as endpoints for the toxicity. The toxic effects were related to the bioaccessible concentration of dissolved Ag in the sediments, assessed with a 2-step extraction procedure. The toxicity of 2 AgNPs was similar and greatly enhanced in the acidic sediment. Because the toxic effects were well related to the bioaccessible concentration of dissolved Ag in the sediments, the toxicity of sediment-associated AgNPs to L. variegatus is suggested to be a function of dissolved Ag rather than a result from NP-specific modes of toxicity. Environ Toxicol Chem 2018;37:1889-1897. © 2018 SETAC.

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Section: Toxicity Of Agno 3 and Agnpsmentioning

confidence: 94%

“…One suggested mechanism is endocytic uptake of AgNPs leading to internal release of Ag þ , the so-called "Trojan horse"-type of behavior (Garca-Alonso et al 2011). Furthermore, activation of oxidative stress response by AgNPs has been found to differ from that caused by Ag þ , indicating a different toxic pathway (Cozzari et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of silver nanoparticles to Lumbriculus variegatus is a function of dissolved silver and promoted by low sediment pH

Rajala¹,

Vehniäinen²,

Väisänen³

et al. 2018

Enviro Toxic and Chemistry

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“…For example, particle size has been shown to influence bioaccumulation, although NM size may not be indicative of exposure if particles aggregate. Many studies have shown that bulk or micron‐size particles are less bioavailable to invertebrates than their dissolved or nanosized counterparts (Pang et al ; Cozzari et al ). Numerous studies have shown that metal uptake rates are faster for ionic forms than for nanosized forms (Zhao and Wang ; Croteau et al , ; Ramskov et al ).…”

Section: Nm Bioavailability and Bioaccumulation In Aquatic Organismsmentioning

confidence: 99%

“…Many studies show significant size-dependent effects, which are not readily explained by metal ion dissolution, the speciation chemistry of the solutes released, or their chemical reactivity. NMs show a separate bioavailable fraction and biological effects (van Hoecke et al 2009;Croteau et al 2011aCroteau et al , 2011bYin et al 2011;Pan et al 2012;Al-Jubory and Handy 2013;Pang et al 2013;Cozzari et al 2015;Taylor et al 2016). For instance, Taylor et al (2016) showed that tightly constrained (in size and oxidation state) and well-characterized ceria NMs gave different algal transcriptomic and metabolomic responses compared with larger scale particles and dissolved phase Ce, although in all cases toxicity was low.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials in the environment: Behavior, fate, bioavailability, and effects—An updated review

Lead

Batley

Alvarez

et al. 2018

Enviro Toxic and Chemistry

496

250

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The present review covers developments in studies of nanomaterials (NMs) in the environment since our much cited review in 2008. We discuss novel insights into fate and behavior, metrology, transformations, bioavailability, toxicity mechanisms, and environmental impacts, with a focus on terrestrial and aquatic systems. Overall, the findings were that: 1) despite substantial developments, critical gaps remain, in large part due to the lack of analytical, modeling, and field capabilities, and also due to the breadth and complexity of the area; 2) a key knowledge gap is the lack of data on environmental concentrations and dosimetry generally; 3) substantial evidence shows that there are nanospecific effects (different from the effects of both ions and larger particles) on the environment in terms of fate, bioavailability, and toxicity, but this is not consistent for all NMs, species, and relevant processes; 4) a paradigm is emerging that NMs are less toxic than equivalent dissolved materials but more toxic than the corresponding bulk materials; and 5) translation of incompletely understood science into regulation and policy continues to be challenging. There is a developing consensus that NMs may pose a relatively low environmental risk, but because of uncertainty and lack of data in many areas, definitive conclusions cannot be drawn. In addition, this emerging consensus will likely change rapidly with qualitative changes in the technology and increased future discharges.

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“…Their exceptional broad-spectrum bactericidal properties and biocompatibility (i.e. as drug delivery agent) have also made AgNP extremely useful in a diverse range of consumer goods (Luoma 2008;Rainville et al 2014;Cozzari et al 2015;Katsumiti et al 2015;Marisa et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Impact of exposure time, particle size and uptake pathway on silver nanoparticle effects on circulating immune cells in mytilus galloprovincialis

Bouallegui

Younes

Turki

et al. 2017

Journal of Immunotoxicology

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Nanomaterials have increasingly emerged as potential pollutants to aquatic organisms. Nanomaterials are known to be taken up by hemocytes of marine invertebrates including Mytilus galloprovincialis. Indeed, assessments of hemocyte-related parameters are a valuable tool in the determination of potentials for nanoparticle (NP) toxicity. The present study assessed the effects from two size types of silver nanoparticles (AgNP: <50 nm and <100 nm) on the frequency of hemocytes subpopulations as immunomodulation biomarkers exposed in a mollusk host. Studies were performed using exposures prior to and after inhibition of potential NP uptake pathways (i.e. clathrin- and caveolae-mediated endocytosis) and over different durations of exposure (3, 6 and 12 h). Differential hemocyte counts (DHC) revealed significant variations in frequency of different immune cells in mussels exposed for 3 hr to either AgNP size. However, as exposure duration progressed cell levels were subsequently differentially altered depending on particle size (i.e. no significant effects after 3 h with larger AgNP). AgNP effects were also delayed/varied after blockade of either clathrin- or caveolae-mediated endocytosis. The results also noted significant negative correlations between changes in levels hyalinocytes and acidophils or in levels basophils and acidophils as a result of AgNP exposure. From these results, we concluded AgNP effects on mussels were size and duration of exposure dependent. This study highlighted how not only was NP size important, but that differing internalization mechanisms could be key factors impacting on the potential for NP in the environment to induce immunomodulation in a model/test sentinel host like M. galloprovincialis.

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Bioaccumulation and oxidative stress responses measured in the estuarine ragworm (Nereis diversicolor) exposed to dissolved, nano- and bulk-sized silver

Cited by 45 publications

References 45 publications

Toxicity of silver nanoparticles to Lumbriculus variegatus is a function of dissolved silver and promoted by low sediment pH

Toxicity of silver nanoparticles to Lumbriculus variegatus is a function of dissolved silver and promoted by low sediment pH

Nanomaterials in the environment: Behavior, fate, bioavailability, and effects—An updated review

Impact of exposure time, particle size and uptake pathway on silver nanoparticle effects on circulating immune cells in mytilus galloprovincialis

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