Electronic waste is an alarming problem faced globally in today’s constantly changing world of technological innovations. The major challenge is to create various innovative and cost-effective ways for decontaminating polluted environments so that they are safe for human habitation, consumption and functioning of various ecosystems that support life. To date, for the management of e-waste no sound eco-friendly technique is available. Hence, biological approach using microorganisms is currently being applied for recovering leached metals from contaminated soil, groundwater, surface water polluted by e-waste, removing toxicity and decontamination of these abiotic components polluted due to e-waste. There are different technologies used for management of e-waste using microorganisms which include microremediation, phytoremediation and vermiremediation. Microremediation involves the use of various microorganisms, phytoremediation the use of plants and symbiotic microorganisms, whereas vermiremediation involves the use of earthworms and necessary associated microbes for e-waste management. These technologies are becoming attractive alternatives as compared to the primitive disposal technologies because they are cost effective, work at ambient temperatures, do not have any major environmental impacts, generate minimum secondary waste and have an inherently aesthetic nature. This paper summarizes the status of ewaste and its harmful effects on life as well as environment and use of innovative microbial biotechnological approaches for handling of e-waste and metal recovery thereof.