Bioaccumulation of polybrominated diphenyl ethers (PBDEs) in Gammarus pulex: Relative importance of different exposure routes and multipathway modeling

Biological fate and effects of propranolol in an experimental aquatic food chain

“…Such an insignificant contribution of the dietary route for bioaccumulation of pharmaceuticals in daphnia has also been observed in the studies for estrone and tetracycline (Gomes et al, 2004;Kim et al, 2014). For historical organic contaminants such as PBDEs and PCBs, bioaccumulation through diet is an important process in the contamination of aquatic invertebrates (Lebrun et al, 2014;Magnusson and Tiselius, 2010), but the results in this study and the literature indicate that this is likely not the case for such pharmaceutical substances. Our results, in fact, may be explained by a recent demonstration that bioaccumulation of ionizable pharmaceuticals (over 70% of drugs are ionizable) by aquatic invertebrates may be more likely to occur from respiratory exchange (inhalation) than assimilation from diet (Du et al, 2014(Du et al, , 2015Meredith-Williams et al, 2012).…”

Dynamic modeling predicts continued bioaccumulation of polybrominated diphenyl ethers (PBDEs) in smallmouth bass (Micropterus dolomiu) post phase-out due to invasive prey and shifts in predation

“…BDE-47 has, however, been shown to be continuously bioaccumulative in carnivorous mammals known to eat predatory fish, while higher brominated congeners did not bioconcentrate, possibly due to debromination to BDE-47 (Kelly et al, 2008). Multichannel models examining biotic debromination of more brominated congeners have been used to simulate the importance of metabolism (Bhavsar et al, 2008;Lebrun et al, 2014) but are similarly limited by parameter inputs and complicated by species specific uptake efficiencies, metabolism pathways, and depuration rates.…”

Changes in antitoxic defense systems of the freshwater amphipod Gammarus pulex exposed to BDE-47 and BDE-99

“…Unfortunately, the release of PBDEs in ecosystems continues due to their presence in products currently in use and new products manufactured using recycled PBDE-containing material (La Guardia et al 2006). It has been shown that PBDEs, especially BDE-47 and BDE-99 congeners, bioaccumulated in several aquatic organisms such as fish or bivalves (Gustafsson et al 1999;Lema et al 2007;, but also amphipod (Tlili et al 2012;Gismondi and Thomé 2014;Lebrun et al 2014). Despite these observations, only few studies have investigated PBDEs toxic effects on invertebrates.…”

“…is a suitable organism for ecotoxicological assessment of environmental pollutants at a large scale because they are present in most rivers in Europe (Ja_ zd_ zewski 1980). In addition, many ecotoxicological studies have been conducted with gammarids as model to evaluate pollutants impacts (Leroy et al 2010;Gismondi et al 2013;Gismondi and Thomé 2014;Lebrun et al 2014), and some antitoxic defences have been developed in Gammarus sp. as biomarkers (Geffard et al 2007;Lacaze et al 2011;Sroda and Cossu-Leguille 2011;Gismondi et al 2012).…”