Biological fate and effects of propranolol in an experimental aquatic food chain

Ding, Jiannan; Lu, Guanghua; Li, Sheng; Nie, Yang; Liu, Jianchao

doi:10.1016/j.scitotenv.2015.06.002

Cited by 47 publications

(14 citation statements)

References 67 publications

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“…However, from the induced P450 activity of trout in vivo and in vitro propranolol was suggested to likely induce its metabolism and it was hypothesised that biotransformation products may be identified (Bartram et al., 2012). More recently trout gill cells have been shown to be capable of propranolol transport and biotransformation (Stott et al., 2015), and in carp a range of biotransformation products were tentatively identified in vivo using UV methods (Ding et al., 2015). Furthermore, sulphate conjugates of pharmaceuticals have not been previously detected in invertebrates.…”

Section: Resultsmentioning

confidence: 99%

Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry

et al. 2017

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Methods were developed to assess uptake and elimination kinetics in Gammarus pulex of nine pharmaceuticals (sulfamethazine, carbamazepine, diazepam, temazepam, trimethoprim, warfarin, metoprolol, nifedipine and propranolol) using targeted LC-MS/MS to determine bioconcentration factors (BCFs) using a 96 h toxicokinetic exposure and depuration period. The derived BCFs for these pharmaceuticals did not trigger any regulatory thresholds and ranged from 0 to 73 L kg−1 (sulfamethazine showed no bioconcentration). Metabolism of chemicals can affect accurate BCF determination through parameterisation of the kinetic models. The added selectivity of LC-MS/MS allowed us to develop confirmatory methods to monitor the biotransformation of propranolol, carbamazepine and diazepam in G. pulex. Varying concentrations of the biotransformed products; 4-hydroxypropranolol sulphate, carbamazepine-10,11-epoxide, nordiazepam, oxazepam and temazepam were measured following exposure of the precursor compounds. For diazepam, the biotransformation product nordiazepam was present at higher concentrations than the parent compound at 94 ng g−1 dw. Overall, the results indicate that pharmaceutical accumulation is low in these freshwater amphipods, which can potentially be explained by the rapid biotransformation and excretion.

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Section: Resultsmentioning

confidence: 99%

Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry

et al. 2017

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“…The activity of CYP1A is traditionally measured as the catalytic activity of EROD, and the EROD activity is widely used as an indicator of environmental contamination. Many pharmaceuticals, such as roxithromycin, propranolol and diphenhydramine, etc., were reported to induce EROD activity in fish liver [ 37 , 38 , 39 ]. The induction of CYP1A is generally mediated via the aryl hydrocarbon receptor (AhR) pathway [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

Bioaccumulation and Biomagnification of 2-Ethylhexyl-4-dimethylaminobenzoate in Aquatic Animals

Zhou

Li³

et al. 2018

IJERPH

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2-Ethylhexyl-4-dimethylaminobenzoate (EHDAB) is a commonly used organic ultraviolet filter. The bioaccumulation and biomagnification of EHDAB were investigated in two aquatic animals, the larvae of midge (Chironomus riparius) and crucian carp (Carassius carassius), and the metabolic enzyme responses in fish liver were determined. EHDAB in the larvae of midge reached a steady state within 10 days of sediment exposure. The biota-sediment accumulation factors ranged from 0.10 to 0.54, and were inversely proportional to the exposure concentrations. The EHDAB-contaminated larvae were used to feed the crucian carp. Within 28 days of feeding exposure, the EHDAB levels in fish tissues gradually increased with the increase of the exposure concentration, exhibiting an apparent concentration-dependence and time-dependence. The liver and kidneys were the main organs of accumulation, and the biomagnification factors of EHDAB ranged from 8.97 to 11.0 and 6.44 to 10.8, respectively. In addition, EHDAB significantly increased the activities of cytochrome P450 (CYP) 1A, CYP3A and glutathione S-transferase in the fish liver. Our results indicate that EHDAB may pose a risk of biomagnification in an aquatic environment and influence the biological processes of exposed organisms.

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“…It should be noted that some APIs may easily be transferred through the trophic route, although their bioaccumulation in fish may be low due to efficient liver metabolism. Such observations have, for instance been made for propranolol which is a widely used beta-blocker (Ding et al 2015) and the macrolide antibiotic roxithromycin (Liu et al 2014). The body of knowledge on accumulation of pharmaceuticals in aquatic biota has extensively increased over the years, yet there remains a need to fully elucidate all transfer routes, estimate environmental and human risks, and screen the content of APIs in waterborne foodstuffs (Puckowski et al 2016).…”

Section: Fate Of Pharmaceuticals In the Freshwater Environmentmentioning

confidence: 99%

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Rzymski

Drewek

Klimaszyk

2017

Limnological Review

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Abstract:The global use of pharmaceuticals is on the systematic rise and leads to contamination of surface waters with xenobiotic compounds with a wide range of bioactivity. Waters that receive urban and medical effluents are particularly threatened. The presence of pharmaceuticals in these ecosystems can lead to unpredictable ecological impacts and responses, and may also have an impact on human health. At the same time the identification and quantification of these chemicals, to a large extent remains a subject to scientific investigation than part of a thorough monitoring programme. Their biological effects on aquatic organisms are mainly recognized experimentally and often using concentrations far exceeding environmentally relevant levels. This review paper defines the main sources of pharmaceuticals in the aquatic environment, discusses the fate of these compounds and summarizes the current state-of-the-art of pharmaceutical monitoring in Polish surface waters.

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Biological fate and effects of propranolol in an experimental aquatic food chain

Cited by 47 publications

References 67 publications

Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry

Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry

Bioaccumulation and Biomagnification of 2-Ethylhexyl-4-dimethylaminobenzoate in Aquatic Animals

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

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