Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

Kamboj, Nikhil; Ressler, Antonia; Hussainova, Irina

doi:10.3390/ma14185338

Cited by 46 publications

(36 citation statements)

References 180 publications

(252 reference statements)

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“…Calcium silicate bioceramics were also reviewed in a recent paper [34]. Both calcium phosphates and calcium silicates were used to fabricate porous ceramic scaffolds for tissue engineering [35]; it was also suggested that porous β-wollastonite has better bone regenerative potential compared to β-tricalcium phosphate scaffolds when implanted in vivo (rabbit calvarial defect model) [36].…”

Section: Resultsmentioning

confidence: 99%

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

et al. 2022

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Implantation of three-dimensional (3D) bioactive glass-derived porous scaffolds is an effective strategy for promoting bone repair and regeneration in large osseous defect sites. The present study intends to expand the potential of a SiO2–P2O5–CaO–MgO–Na2O–CaF2 glass composition, which has already proven to be successful in regenerating bone in both animals and human patients. Specifically, this research work reports the fabrication of macroporous glass–ceramic scaffolds by the foam replica method, using the abovementioned bioactive glass powders as a parent material. The sinter-crystallization of the glass powder was investigated by hot-stage microscopy, differential thermal analysis, and X-ray diffraction. Scanning electron microscopy was used to investigate the pore–strut architecture of the resultant glass–ceramic scaffolds in which diopside, fluorapatite, and wollastonite crystallized during thermal treatment. Immersion studies in simulated body fluids revealed that the scaffolds have bioactive behavior in vitro; the mechanical properties were also potentially suitable to suggest use in load-bearing bone applications.

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Section: Resultsmentioning

confidence: 99%

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

et al. 2022

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“…Frontiers in Chemistry frontiersin.org (Kamboj et al, 2021), metals (Xia et al, 2023a), and their composites (Liu et al, 2022a) for bone tissue engineering.…”

Section: L-pbf As the Mainstream Manufacturing Technology For Am Mg A...mentioning

confidence: 99%

“…L-PBF is a laser AM technology based on the layered construction of complex customized implants using high-intensity laser beams. Therefore, it has been extensively investigated for the fabrication of bone implants using polymers ( Kamboj et al, 2021 ), metals ( Xia et al, 2023a ), and their composites ( Liu et al, 2022a ) for bone tissue engineering. L-PBF has shown excellent performance in customizing products with complex shapes.…”

Section: Am and Mg Alloys For Bone Repairmentioning

confidence: 99%

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

et al. 2022

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Bone defect repair is a complicated clinical problem, particularly when the defect is relatively large and the bone is unable to repair itself. Magnesium and its alloys have been introduced as versatile biomaterials to repair bone defects because of their excellent biocompatibility, osteoconductivity, bone-mimicking biomechanical features, and non-toxic and biodegradable properties. Therefore, magnesium alloys have become a popular research topic in the field of implants to treat critical bone defects. This review explores the popular Mg alloy research topics in the field of bone defects. Bibliometric analyses demonstrate that the degradation control and mechanical properties of Mg alloys are the main research focus for the treatment of bone defects. Furthermore, the additive manufacturing (AM) of Mg alloys is a promising approach for treating bone defects using implants with customized structures and functions. This work reviews the state of research on AM-Mg alloys and the current challenges in the field, mainly from the two aspects of controlling the degradation rate and the fabrication of excellent mechanical properties. First, the advantages, current progress, and challenges of the AM of Mg alloys for further application are discussed. The main mechanisms that lead to the rapid degradation of AM-Mg are then highlighted. Next, the typical methods and processing parameters of laser powder bed fusion fabrication on the degradation characteristics of Mg alloys are reviewed. The following section discusses how the above factors affect the mechanical properties of AM-Mg and the recent research progress. Finally, the current status of research on AM-Mg for bone defects is summarized, and some research directions for AM-Mg to drive the application of clinical orthopedic implants are suggested.

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“…Cells, growth factors, and scaffolds are a necessary triad for tissue engineering. Despite advances in scaffold development and the identification of new growth factors and their genetic manipulation [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ], delivering sufficient numbers of cells and maintaining them in areas of interest, regardless of whether for ex vivo tissue engineering or in situ regeneration, has been challenging [ 1 , 12 , 15 , 16 , 17 , 18 , 19 , 20 ]. The effective delivery of stem cells or osteogenic cells derived from bone marrow or other source organs has been investigated in the context of tissue engineering and regeneration [ 12 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Cell Delivery System Exploiting Synergy between Fresh Titanium and Fibronectin

Hirota

Hori

Sugita

et al. 2022

Cells

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Delivering and retaining cells in areas of interest is an ongoing challenge in tissue engineering. Here we introduce a novel approach to fabricate osteoblast-loaded titanium suitable for cell delivery for bone integration, regeneration, and engineering. We hypothesized that titanium age influences the efficiency of protein adsorption and cell loading onto titanium surfaces. Fresh (newly machined) and 1-month-old (aged) commercial grade 4 titanium disks were prepared. Fresh titanium surfaces were hydrophilic, whereas aged surfaces were hydrophobic. Twice the amount of type 1 collagen and fibronectin adsorbed to fresh titanium surfaces than aged titanium surfaces after a short incubation period of three hours, and 2.5-times more fibronectin than collagen adsorbed regardless of titanium age. Rat bone marrow-derived osteoblasts were incubated on protein-adsorbed titanium surfaces for three hours, and osteoblast loading was most efficient on fresh titanium adsorbed with fibronectin. The number of osteoblasts loaded using this synergy between fresh titanium and fibronectin was nine times greater than that on aged titanium with no protein adsorption. The loaded cells were confirmed to be firmly attached and functional. The number of loaded cells was strongly correlated with the amount of protein adsorbed regardless of the protein type, with fibronectin simply more efficiently adsorbed on titanium surfaces than collagen. The role of surface hydrophilicity of fresh titanium surfaces in increasing protein adsorption or cell loading was unclear. The hydrophilicity of protein-adsorbed titanium increased with the amount of protein but was not the primary determinant of cell loading. In conclusion, the osteoblast loading efficiency was dependent on the age of the titanium and the amount of protein adsorption. In addition, the efficiency of protein adsorption was specific to the protein, with fibronectin being much more efficient than collagen. This is a novel strategy to effectively deliver osteoblasts ex vivo and in vivo using titanium as a vehicle.

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Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

Cited by 46 publications

References 180 publications

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

Foam-Replicated Diopside/Fluorapatite/Wollastonite-Based Glass–Ceramic Scaffolds

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

A Novel Cell Delivery System Exploiting Synergy between Fresh Titanium and Fibronectin

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