Bioactive Chitosan-Based Organometallic Scaffolds for Tissue Engineering and Regeneration

Zakhireh, Solmaz; Barar, Jaleh; Adibkia, Khosro; Beygi‐Khosrowshahi, Younes; Fathi, Marziyeh; Omidain, Hossein; Omidi, Yadollah

doi:10.1007/s41061-022-00364-y

Cited by 12 publications

(5 citation statements)

References 223 publications

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“…Where chitosan may have provided the appropriate surface chemistry due to the presence of hydroxyl and amine groups over it, and with the addition of MALD, the pore surface roughness has also been enhanced and led to improved cell adhesion. [ 74,75 ] The cell attachment on SMALD 10% was slightly upregulated by 8–10% compared to the control and showed almost 2‐fold more cell attachment than SMALD 30%, as shown in Figure 7d. Results suggested that all the scaffolds have been proven non‐toxic to hMSCs and provide a responsive environment to the cells for their adhesion and growth.…”

Section: Resultsmentioning

confidence: 93%

Modified‐Hydroxyapatite‐Chitosan Hybrid Composite Interfacial Coating on 3D Polymeric Scaffolds for Bone Tissue Engineering

Poddar,

Singh,

Rao

et al. 2023

Macromolecular Bioscience

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Three‐dimensional scaffolds have huge limitations due to their low porosity, mechanical strength, and lack of direct cell‐bioactive drug contact. Whereas a drug like alendronate's ability to stimulate osteogenesis in osteoblasts and bone marrow mesenchymal stem cells has attracted its therapeutic use, it is hard to administer due to its low bioavailability, quick onset, and lack of site‐specificity. The proposed scaffold architecture allows cells to access the bioactive surface at their apex by interacting at the scaffold's interfacial layer. The interface has been coated with alendronate‐modified hydroxyapatite (MALD) enclosed in a chitosan matrix, the inner pore wall structure of 3D polycaprolactone (PCL) scaffolds to mimic the native environment and provide the direct interaction of cell to bioactive layer and mechanical strength will be provided by the skeleton of PCL. The MALD composite's HAP component will govern ALD's behavior, and local calcium ion concentration increases hMSC proliferation and differentiation. MALD showed total release of 86.28±0.22, and particle size of 273.7±108 nm. XPS and SEM investigation of the 3‐D PCL scaffold structure shows inspiring particle deposition with chitosan over the interface and reinforcing. All scaffolds enhanced cell adhesion, proliferation, and osteocyte differentiation for over a week without in vitro cell toxicity with 3.03±0.2 kPa mechanical strength.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 93%

Modified‐Hydroxyapatite‐Chitosan Hybrid Composite Interfacial Coating on 3D Polymeric Scaffolds for Bone Tissue Engineering

Poddar,

Singh,

Rao

et al. 2023

Macromolecular Bioscience

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“…Surface-functionalized MNPs offer unparalleled targeting precision. The conjugation of targeting lig- Tissue engineering and regeneration has been shown to be possible by Chitosan (CS)-based NP formulations, including CS/ferromagnetic scaffolds, owing to the efficient interaction of -NH 2 groups (CS) with the MNPs' polymeric coating [35]. Such effective CS-coating of the magnetite magnetic core also prevents further oxidation of magnetite Fe 3 O 4 to hematite Fe 2 O 3 .…”

Section: Surface Functionalization For Drug Deliverymentioning

confidence: 99%

Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Comanescu

2023

Coatings

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In recent years, significant progress has been made in the surface functionalization of magnetic nanoparticles (MNPs), revolutionizing their utility in multimodal imaging, drug delivery, and catalysis. This progression, spanning over the last decade, has unfolded in discernible phases, each marked by distinct advancements and paradigm shifts. In the nascent stage, emphasis was placed on foundational techniques, such as ligand exchange and organic coatings, establishing the groundwork for subsequent innovations. This review navigates through the cutting-edge developments in tailoring MNP surfaces, illuminating their pivotal role in advancing these diverse applications. The exploration encompasses an array of innovative strategies such as organic coatings, inorganic encapsulation, ligand engineering, self-assembly, and bioconjugation, elucidating how each approach impacts or augments MNP performance. Notably, surface-functionalized MNPs exhibit increased efficacy in multimodal imaging, demonstrating improved MRI contrast and targeted imaging. The current review underscores the transformative impact of surface modifications on drug delivery systems, enabling controlled release, targeted therapy, and enhanced biocompatibility. With a comprehensive analysis of characterization techniques and future prospects, this review surveys the dynamic landscape of MNP surface functionalization over the past three years (2021–2023). By dissecting the underlying principles and applications, the review provides not only a retrospective analysis but also a forward-looking perspective on the potential of surface-engineered MNPs in shaping the future of science, technology, and medicine.

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“…In addition, most metal materials have an extremely low degradation rate, which requests additional operation for removal. Over the past 20 years, the modification of current medical metal materials with more stiffness, corrosion resistance, and biocompatibility was the goal in the research field of biodegradable metal and biological functionalization metal [ 56 ]. Using surface bioactive coating, drug coating and other related surface modification technologies was also found to further develop metal medical treatment appliance products.…”

Section: Tissue Engineering Technologies In Bone Regeneration and Repairmentioning

confidence: 99%

Bone Tissue Engineering in the Treatment of Bone Defects

et al. 2022

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Bones play an important role in maintaining exercise and protecting organs. Bone defect, as a common orthopedic disease in clinics, can cause tremendous damage with long treatment cycles. Therefore, the treatment of bone defect remains as one of the main challenges in clinical practice. Today, with increased incidence of bone disease in the aging population, demand for bone repair material is high. At present, the method of clinical treatment for bone defects including non-invasive therapy and invasive therapy. Surgical treatment is the most effective way to treat bone defects, such as using bone grafts, Masquelet technique, Ilizarov technique etc. In recent years, the rapid development of tissue engineering technology provides a new treatment strategy for bone repair. This review paper introduces the current situation and challenges of clinical treatment of bone defect repair in detail. The advantages and disadvantages of bone tissue engineering scaffolds are comprehensively discussed from the aspect of material, preparation technology, and function of bone tissue engineering scaffolds. This paper also summarizes the 3D printing technology based on computer technology, aiming at designing personalized artificial scaffolds that can accurately fit bone defects.

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Bioactive Chitosan-Based Organometallic Scaffolds for Tissue Engineering and Regeneration

Cited by 12 publications

References 223 publications

Modified‐Hydroxyapatite‐Chitosan Hybrid Composite Interfacial Coating on 3D Polymeric Scaffolds for Bone Tissue Engineering

Modified‐Hydroxyapatite‐Chitosan Hybrid Composite Interfacial Coating on 3D Polymeric Scaffolds for Bone Tissue Engineering

Recent Advances in Surface Functionalization of Magnetic Nanoparticles

Bone Tissue Engineering in the Treatment of Bone Defects

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