Bioactive components of ethnomedicine Eerdun Wurile regulate the transcription of pro-inflammatory cytokines in microglia

Qiburi, Qiburi; Ganbold, Tsogzolmaa; Bao, Qingming; Da, Man; Aoqier, Aoqier; Temuqile, Temuqile; Baigude, Huricha

doi:10.1016/j.jep.2019.112241

Cited by 17 publications

(14 citation statements)

References 26 publications

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“…This inhibition occurs both at the protein level and at the mRNA regulation level. In vitro studies have shown that the inhibition of these cytokines was able to block the migration and growth of neutrophils and macrophages, while in vivo, it promoted a reduction in mice paw edema [ 16 , 24 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Pharmacological and Therapeutic Potential of Myristicin: A Literature Review

et al. 2021

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Natural products have been used by humanity for many centuries to treat various illnesses and with the advancement of technology, it became possible to isolate the substances responsible for the beneficial effects of these products, as well as to understand their mechanisms. In this context, myristicin, a substance of natural origin, has shown several promising activities in a large number of in vitro and in vivo studies carried out. This molecule is found in plants such as nutmeg, parsley, carrots, peppers, and several species endemic to the Asian continent. The purpose of this review article is to discuss data published in the last 10 years at Pubmed, Lilacs and Scielo databases, reporting beneficial effects, toxicity and promising data of myristicin for its future use in medicine. From 94 articles found in the literature, 68 were included. Exclusion criteria took into account articles whose tested extracts did not have myristicin as one of the major compounds.

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Section: Resultsmentioning

confidence: 99%

Pharmacological and Therapeutic Potential of Myristicin: A Literature Review

et al. 2021

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“…Myristicin (27) Cancer chemopreventive agent [51], anti-inflammatory [52], antimicrobial against B. subtilis, E. coli, S. aureus [110], hepatoprotective [111], cytoprotective against hypoxia-induced apoptosis and endoplasmic reticulum stress [112], down-regulates expression of pro-inflammatory cytokines [113], cytotoxic against SK-N-SH (human neuroblastoma) cancer cell line [114], acetylcholinesterase inhibitor [115], antiproliferative [116], insecticidal against Culex pipiens and Aedes aegypti [117].…”

Section: Secondary Metabolite Biological Activitiesmentioning

confidence: 99%

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Miski

2021

Plants

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Silphion was an ancient medicinal gum-resin; most likely obtained from a Ferula species growing in the Cyrene region of Libya ca. 2500 years ago. Due to its therapeutic properties and culinary value, silphion became the main economic commodity of the Cyrene region. It is generally believed that the source of silphion became extinct in the first century AD. However, there are a few references in the literature about the cultivated silphion plant and its existence up to the fifth century. Recently, a rare and endemic Ferula species that produces a pleasant-smelling gum-resin was found in three locations near formerly Greek villages in Anatolia. Morphologic features of this species closely resemble silphion, as it appears in the numismatic figures of antique Cyrenaic coins, and conform to descriptions by ancient authors. Initial chemical and pharmacological investigations of this species have confirmed the medicinal and spice-like quality of its gum-resin supporting a connection with the long-lost silphion. A preliminary conservation study has been initiated at the growth site of this rare endemic Ferula species. The results of this study and their implications on the regional extinction event, and future development of this species will be discussed.

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“…It was discovered that EW can regulate the gene expression in the peri-ischemic center, resulting in significant upregulation of growth factors including TGFβ, Igf1, and Igf2, which may contribute to nerve tissue repair and growth. EW treatment in a rat middle cerebral artery occlusion (MCAO) model also induced significant upregulation of microglia markers, including Iba-1, CX3CR1, CD68 and CSF1R, which may have resulted from anti-inflammatory polarization of microglia upon EW treatment (Gaowa et al, 2018;Qiburi et al, 2020). We hypothesize that the active molecules in EW also protect nerve tissue through direct intervention with neurons.…”

Section: Introductionmentioning

confidence: 93%

Eerdun Wurile protects neuron and promotes neurite outgrowth through regulation of apoptotic gene expression in PC-12 cells

La¹,

Ganbold²,

Saren³

et al. 2020

J. Med. Plants Res.

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Eerdun Wurile (EW) is one of the most widely used traditional Mongolian medicines for stroke recovery. Previous studies revealed that EW regulates brain gene expression in a rat model of middle cerebral artery occlusion (MCAO). However, the fraction of active components and the specific genes regulated by such fractions have not been elucidated clearly. The study shows that the extracts of EW regulate the expression of genes involved in oxidative stress and apoptosis in rat pheochromocytoma (PC-12) cells. Hydrogen peroxide (H 2 O 2)-induced cell death was reversed by EW extracts, and reactive oxygen species (ROS) production was reduced, while superoxide dismutase (SOD) activity as well as catalase (CAT) activity increased significantly. Moreover, the expression of Bcl-2, PARP and NF-kB p65 was upregulated by EW extract, while Bax was downregulated. Similarly, caspase 9 and Jnk was remarkably downregulated by EW extracts. Significantly, EW extracts promoted the neurite outgrowth of PC-12 cells. Our data collectively suggested that EW contains active fractions that regulate the expression of genes involved in oxidative stress and cell apoptosis, which may contribute to the neural protection effect of EW.

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Bioactive components of ethnomedicine Eerdun Wurile regulate the transcription of pro-inflammatory cytokines in microglia

Cited by 17 publications

References 26 publications

Pharmacological and Therapeutic Potential of Myristicin: A Literature Review

Pharmacological and Therapeutic Potential of Myristicin: A Literature Review

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Eerdun Wurile protects neuron and promotes neurite outgrowth through regulation of apoptotic gene expression in PC-12 cells

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