Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

Costa, David G.; Rangel, Luciana P.; Quarti, Julia; Santos, Ronimara A.; Silva, Jerson L.; Fialho, Eliane

doi:10.3390/molecules25153531

Cited by 32 publications

(14 citation statements)

References 237 publications

(290 reference statements)

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“…Rapid absorption, poor bioavailability, and low aqueous solubility are some of the crucial limitations and challenges of the in vivo use of resveratrol [12,13]. Therefore, different methodological approaches, such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), have been used to improve the poor aqueous solubility and the low bioavailability of resveratrol [14].…”

Section: Absorption and Metabolism Of Resveratrolmentioning

confidence: 99%

Anti-Inflammatory Action and Mechanisms of Resveratrol

et al. 2021

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Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits anti-oxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined. Multiple experimental studies that illustrate regulatory mechanisms and the immunomodulatory function of resveratrol both in vivo and in vitro. The data acquired from those studies are discussed.

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Section: Absorption and Metabolism Of Resveratrolmentioning

confidence: 99%

Anti-Inflammatory Action and Mechanisms of Resveratrol

et al. 2021

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“…A moderate amount of alcohol from wine consumption (150-300 mL/day) can protect against cardiovascular disease, dietary cancers, ischemic stroke, diabetes, hypertension and so on [50]. Additionally, the polyphenols from wine have antioxidant, antiviral, antibacterial and anti-carcinogen proprieties which imply health benefits [50][51][52][53]. Apart this, vine and wine has an important economic status, including in the world trade market as well as the agro-tourism to wineries and wine-growing areas.…”

Section: Introductionmentioning

confidence: 99%

Helium Atmospheric Pressure Plasma Jet Source Treatment of White Grapes Juice for Winemaking

Huzum

Nastuta

2021

Applied Sciences

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In the last few years, new emerging technologies to develop novel winemaking methods were reported. Most of them pointed out the need to assess the barrel aging on the wine product, fermentation process, green technologies for wine treatment for long term storage. Among these, plasma technologies at atmospheric pressure are on the way of replacing old and expensive methods for must, wine and yeast treatment, the goal being the long-term storage, aging and even decontamination of such products, and seems to meet the requirements of the winemakers. Using the principles of dielectric barrier discharge, we power up an atmospheric pressure plasma jet in helium. This plasma is used for treatment of fresh must obtained from white grapes. Our research manuscript is focused on the correlation of plasma parameters (applied voltage, plasma power, reactive species, gas temperature) with the physico-chemical properties of white must and wine (1 and 2 years old), via ultraviolet–visible and infrared spectroscopy, and colorimetry. Two types of white must were plasma treated and studied over time. The 10 W plasma source did not exceed 40 °C during treatment, the must did not suffer during thermal treatment. A higher quantity of RONS was observed during plasma-must exposure, supporting further oxidation processes. The UV-Vis and FTIR spectroscopy revealed the presence of phenols, flavones and sugar in the wine samples. Simultaneous visualization of CIE L*a*b* and RGB in color space charts allows easier understanding of wine changing in color parameters. These experimental results supporting the possible usability of atmospheric pressure plasma for winemaking.

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“…A correct and complete understanding of phytochemical compositions and antimicrobial activities of different anatomical parts of grapes from Vitis vinifera L., as well as differences resulted from the variety and/or the culture management system, may lead to developing new applications, much more specific, from a wide spectrum already known. Thus, recent studies [19,40,[66][67][68][69] have shown a direct relationship between the therapeutic benefit, chemo-preventive effects (anticancer) and the red grapes consumption, in various forms. The role of the bioactive compounds (e.g., proanthocyanidins, anthocyanins and other flavonoids, hydroxycinnamates, and stilbenes such as resveratrol) has been investigated, and antioxidant, antimicrobial, antitumor effects have been found, as well as anti-inflammatory properties, and inhibiting lipid peroxidation.…”

Section: Grapes As Functional Foodsmentioning

confidence: 99%

Romanian Organic and Conventional Red Grapes Vineyards as Potential Sources of High Value-Added Products, in a Circular Economy Approach

Nicolescu¹,

Bumbac²,

Rădulescu³

et al. 2022

Grapes and Wine

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The use of natural ingredients with active functions has been intensively studied in the last years, as a consequence to consumer preferences for organic products. Application of circular economy principles determined a significant research activity in the viticulture field. The use or re-use of vines parts for so-called nutraceuticals or other consumer-goods applications, are basically centered on their phytochemical and microbiological characterization. Eurostat updates ranks Romania fifth among the EU member states, with a total area under vines of 183,717 hectares. Characterization of four Vitis vinifera L. varieties, out of which one pure Romanian variety (Feteasca Neagra), cultivated in organic and conventional vineyards, together with pedoclimatic conditions have been provided. Data on phytochemical parameters and antimicrobial activity of extracts obtained from different anatomic parts of grapes were included. Analytical protocols and techniques applied were presented, together with data and results interpretation. Several chemometric algorithms have been used as complementary tools for interpretation of the instrumental analytical data.

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Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

Cited by 32 publications

References 237 publications

Anti-Inflammatory Action and Mechanisms of Resveratrol

Anti-Inflammatory Action and Mechanisms of Resveratrol

Helium Atmospheric Pressure Plasma Jet Source Treatment of White Grapes Juice for Winemaking

Romanian Organic and Conventional Red Grapes Vineyards as Potential Sources of High Value-Added Products, in a Circular Economy Approach

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