Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives

Shi, Yan; Si, Dun; Chen, Donghong; Zhang, Xinfeng; Zhao, Han; Yu, Qiang; Liu, Jingjing; Si, Jinping

doi:10.1016/j.foodchem.2022.135183

Cited by 41 publications

(33 citation statements)

References 149 publications

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“…Such as, polysaccharides, flavonoids and saponins of genus Polygonatum have function about controlling blood glucose and preventing obese diabetes. 17 Xanthohumol of Humulus lupulus L .has strong anti-cancer activity against various types of cancer cells. 18 A considerable phenolic content for both varieties in Phaseolus vulgari , and a strong antiobesity activity.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation

Wei¹,

Li²,

Guo³

et al. 2023

DDDT

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Objective Baolier Capsule (BLEC) is a Traditional Mongolian Medicine comprising fifteen herbs. This study aims to illustrate the synergistic mechanism of BLEC in the treatment of Coronary Artery Disease (CAD) by using network pharmacology method, molecular docking and experimental validation. Methods Searching and screening the active ingredients of different herbs in BLEC and target genes related to CAD in multiple databases. Subsequently, Protein–Protein Interactions Network (PPI-Net), gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment were used to identify the key targets. AutoDock was used to verify the binding ability between the active ingredient and key target through molecular docking. Reverse Transcription-Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) was used to verify the effect of active ingredient of BLEC on the key target gene. Finally, effect of BLEC on the degree of blood lipids and atherosclerosis was validated by animal experiment. Results There are 144 active components and 80 CAD-related targets that are identified in BLEC in the treatment of CAD. What is more, 8 core genes were obtained by clustering and topological analysis of PPI-Net. Further, GO and KEGG analysis showed that fluid shear stress and atherosclerosis are the key pathways for BLEC to treat CAD. These results were validated by molecular docking method. In vitro, active compounds of BLEC (Quercetin, luteolin, kaempferol, naringenin, tanshinone IIA, β-carotene, 7-O-methylisomucronulatol, piperine, isorhamnetin and Xyloidone) can inhibit 8 core gene (AKT1, EGFR, FOS, MAPK1, MAPK14, STAT3, TP53 and VEGFA) expression. Moreover, BLEC not only improve blood lipid levels but also inhibit the development of atherosclerosis in ApoE-knockout mice. Conclusion Our research first revealed the basic pharmacological effects and related mechanisms of in the treatment of CAD. The predicted results provide some theoretical support for BLEC or its important active ingredients to treat CAD.

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Section: Discussionmentioning

confidence: 99%

Exploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation

Wei¹,

Li²,

Guo³

et al. 2023

DDDT

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“…Huangjing, either processed or not, has been consumed as medicine and food since ancient times with no toxicity records (Shi et al, 2022).…”

Section: Huangjing In Food and Medicinementioning

confidence: 99%

“…Huangjing, either processed or not, has been consumed as medicine and food since ancient times with no toxicity records (Shi et al., 2022). The acute toxicity, chronic toxicity, and genetic toxicity test with aqueous extracts of Huangjing in mice showed no abnormal signs or death (Chen et al., 2001).…”

Section: Huangjing In Food and Medicinementioning

confidence: 99%

Huangjing—From medicine to healthy food and diet

Shi

Liu

et al. 2023

Food Frontiers

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Diet‐related chronic diseases are becoming more common where many consumers and nutritionists are seeking food and lifestyle interventions to improve health and standard of living. To supplement regular dietary intake, scientists are seeking to develop new crops that are productive and nutritious, which can improve health outcomes. This review focused on the history of Huangjing as a medicine, healthy food as part of a diverse diet and as an input into pharmacology uses. The sustainable production of Huangjing and the development of health‐promoting Huangjing products are reviewed through consulting the “Chinese Pharmacopoeia” along with other herbal textual research and modern research publications. Hence, the potential development of Huangjing as a regular part of a healthy diet is discussed. Huangjing has been used as medicine and food in China for over 2000 years. While it contains no starch, it is rich in fructan, saponins, and flavonoids, which have been reported to prevent and treat chronic diseases such as diabetes and obesity. As part of a healthy diet, Huangjing has been developed into innovative products used in meals, snacks, drinks, health foods, and drugs. Furthermore, Huangjing is a perennial plant, is suitable for cultivation in forests, and does not occupy fertile farmland. It is proposed to use the achievements of genomics and targeted precision breeding to make in‐forest cultivation of Huangjing more productive, comprehensively nutritious, and environmentally friendly and obtain high‐quality food from forests and mountains, providing Chinese wisdom for the global food and nutrition security issue.

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“…(PK), or P. cyrtonema Hua (PC) according to Chinese Pharmacopoeia and P. filipes Merr. (PF) according to the Processing Norms of Zhejiang province ( Shi et al, 2023 , Zhang et al, 2020 ). Yuzhu (Latin name: Polygonati Odorati Rhizoma), obtained from P. odoratum (Mill.)…”

Section: Introductionmentioning

confidence: 99%

“…Huangjing and Yuzhu have been used in traditional Chinese medicine to invigorate qi (life energy) and nourish yin (one of the qualities of qi ) ( Shi et al, 2023 ). Huangjing invigorates the spleen, moistens the lung, and benefits the kidneys, and Yuzhu relieves dryness, promotes fluid production, quenches thirst, and increases vitality ( Li et al, 2021 , Zhou et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Variations in the morphological and chemical composition of the rhizomes of Polygonatum species based on a common garden experiment

et al. 2023

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Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives

Cited by 41 publications

References 149 publications

Exploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation

Exploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation

Huangjing—From medicine to healthy food and diet

Variations in the morphological and chemical composition of the rhizomes of Polygonatum species based on a common garden experiment

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