Bioactive compounds in bee propolis for drug discovery

Kumazawa, Shigenori

doi:10.1063/1.5023948

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…By contrast, propolis obtained from pacific regions like Okinawa Island and mainland Japan contained prenylflavonoids not observed in temperate and tropical regions [36]. While research performed by Raghukumar et al, on propolis samples from The Solomon Island led to the isolation of prenylflavonones including propolin H, G, and D and C This led to the conclusion that the plant source for pacific propolis is Macaranga tanarius [36,37].…”

Section: Constituent Profilementioning

confidence: 97%

“…Further analysis performed by Alencar et al, using GC-MS identified seven new compounds in Brazilian red propolis four of which were is flavones including homopterocarpin, medicarpin and 4′,7-dimethoxy-2′isoflavonol. Also, phenolic compounds such as vestitol, neovestitol, and medicarpin were found in red propolis from Brazil [35,36].…”

Section: Constituent Profilementioning

confidence: 99%

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A Review on the Antimicrobial Activity of Propolis and its Synergy with Other Antimicrobial Compounds

2019

Medical &Amp; Clinical Research

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The alarming increase in the development of drug resistant microbes and the decrease in the efficacy of numerous antibiotics have led to the rise in patient mortality and morbidity affecting various fields of medicine. To combat this development and or the improvement of drugs are paramount. Natural products have long been utilized in the treatment of diseases showing broad spectrum of activity against a wide range of pathogens. In this study, the potential application of propolis to combat drug resistant microbes is reviewed, highlighting the presence and diversity of bioactive compounds with focus on its antimicrobial activity against a number of drug resistant microbes and its synergistic properties with other antimicrobial compounds. It is hoped that this study would enable researchers to continue to analyse propolis compounds and its interactions with other antimicrobial compounds which ultimately paves the way for new drug development.

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Section: Constituent Profilementioning

confidence: 97%

Section: Constituent Profilementioning

confidence: 99%

A Review on the Antimicrobial Activity of Propolis and its Synergy with Other Antimicrobial Compounds

2019

Medical &Amp; Clinical Research

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“…This suggests that propolis supplementation might be beneficial in reducing N loss via ammonia production. In addition, propolis has been shown to have antioxidant, antibacterial, and anti-inflammatory effects [16][17][18]. However, due to limited data on moringa and even more lacking raw propolis, their roles as functional feeds for cattle cannot be generalized.…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera and Propolis in Cattle Nutrition: Characterization of Metabolic Activities in the Rumen In Vitro

et al. 2022

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Moringa oleifera by-products such as seed cake and leaves are protein-rich ingredients, while raw propolis has the potential to influence ruminal protein metabolism. These substances are also known to be sources of functional compounds. With these properties, they could modulate ruminal fermentation activities. Using the rumen simulation technique, we investigated ruminal fermentation and the antioxidant properties of four dietary treatments. These included a control diet (CON) without supplementation; the CON diet top-dressed on a dry matter (DM) basis, either with moringa seed cake (MSC, containing 49% crude protein (CP)), moringa leaf powder (ML, containing 28% CP), or raw propolis (PRO, 3% CP). MSC, ML, and PRO accounted for 3.8, 7.4, and 0.1% of the total diet DM, respectively. Both ML and MSC resulted in 14 and 27% more ammonia concentration, respectively than CON and PRO (p < 0.05). MSC increased the propionate percentage at the expense of acetate (p < 0.05). Both ML and MSC decreased methane percentages by 7 and 10%, respectively, compared to CON (p < 0.05). The antioxidant capacity of the moringa seed cake, moringa leaf powder, and raw propolis were 1.14, 0.56, and 8.56 mg Trolox/g DM, respectively. However, such differences were not evident in the fermentation fluid. In conclusion, the supplementation of moringa seed cake desirably modulates rumen microbial activities related to protein and carbohydrate metabolism.

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Propolis efficacy on SARS-COV viruses: a review on antimicrobial activities and molecular simulations

Ghosh

Al‐Sharify

Maleka

et al. 2022

Environ Sci Pollut Res

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Bioactive compounds in bee propolis for drug discovery

Cited by 3 publications

References 11 publications

A Review on the Antimicrobial Activity of Propolis and its Synergy with Other Antimicrobial Compounds

A Review on the Antimicrobial Activity of Propolis and its Synergy with Other Antimicrobial Compounds

Moringa oleifera and Propolis in Cattle Nutrition: Characterization of Metabolic Activities in the Rumen In Vitro

Propolis efficacy on SARS-COV viruses: a review on antimicrobial activities and molecular simulations

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