Bioactive compounds in Magnifera indica demonstrates dose-dependent anti- inflammatory effects

Abstract

Magnifera indica (MI) is one of the notable medicinal plants use for the treatment of inflammatory diseases in folkloric medicine. Recent studies by present author demonstrated anti-inflammatory effects of Mangifera indicato have dose-dependent effects, pointing out its dose-dependent effects to be relevant in therapeutics investigations. However, as far as we know, Mangifera indica has one or no translational drugs and products already established in clinical trials or in pharmaceutical practice. This is rather a concern to drug discovery and optimization of research findings, particularly in case of Magnifera indica plant which has various medicinal efficaciesalready ascribed to its properties. It has been investigated that, Mangiferin a very potent bioactive compound found inside extracts of Magniferaindica, is a polyphenolic and a glucosylxanthone which has strong antioxidant and anti-inflammatory properties. Hence, various effects such as anti-bacterial, antipyretic, antidiarrhoeal, antiallergic, immunomodulation, anti-microbial, gastroprotective have been ascribed to the medicinal use of this plant. However, some other potent natural phytochemicals found in Mangiferaindica which include saponin, tannins, steroids, flavoniod, alkaloids, cardiac glycosides, reducing sugar and anthraquinone, have been discovered to be useful in herbal medicine and cosmetics productions. Thus, this paper focus on the need to encourage translational studies in order to improvelead optimization as well asthe need to adequately promote further research that may formulate bioactive compounds in Magnifera indica for the purpose of treating inflammatory diseases and stress related disorders. Also, this paper emphasized on the necessity in conducting more clinical trials using Mangifera indica bioactive compounds for variety of conditions in human volunteers.

In Invivo model of Parkinson’s syndrome, concurrent administrations of anti-inflammatory drugs changed behavioral deficits

“…Nevertheless, largely supported information had ascertained that, the NSAIDs and some phytochemicals can inhibit cellular components of inflammation. They also have the ability to inhibit the release of chemoattractants which is contributing to the movements of the leukocyte to the site of injury [34,35] .…”