Bioactive constituents from seeds of <i>Annona Senegalensis</i> Persoon (Annonaceae)

Tamfu, Alfred Ngenge; Fotsing, Maurice Tagatsing; Talla, Emmanuel; Jabeen, Almas; Tanyi, Joseph Mbafor; Shaheen, Farzana

doi:10.1080/14786419.2019.1634713

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…senegalensis plant has been demonstrated properties including antibacterial (Ahmed et al, 2020;Lall et al, 2017), anticonvulsant, antiinflammatory (Konaté et al, 2021;Tamfu et al, 2021), antidiarrhea (Ahmed et al, 2020;Djoza et al, 2017), antimalarial (Ngwewondo et al, 2019), smooth muscle relaxant (Adisa et al, 2019), and sedative, central nervous depressant, and anticonvulsant (Adisa et al, 2019).…”

Section: Hibiscetin Kaempferol Luteolinmentioning

confidence: 99%

“…The usefulness of the plant for medicinal purposes has been attributed to the presence of bioactive compounds (phytochemicals) including alkaloids (Inkoto et al, 2018), anthocyanins (Konaté et al, 2021), flavonoids (Lall et al, 2017), glycosides (Musa et al, 2017;Tamfu et al, 2021), steroids (Konaté et al, 2021), tannins (Musa et al, 2017), and saponins and volatile oils (Ibrahim et al, 2019). The stem extracts of this plant also showed antioxidant and radical scavenging activities (Ahmed et al, 2020).…”

Section: Hibiscetin Kaempferol Luteolinmentioning

confidence: 99%

“…A. senegalensis plant has been demonstrated properties including antibacterial (Ahmed et al, 2020; Lall et al, 2017), anticonvulsant, anti‐inflammatory (Konaté et al, 2021; Tamfu et al, 2021), antidiarrhea (Ahmed et al, 2020; Djoza et al, 2017), antimalarial (Ngwewondo et al, 2019), smooth muscle relaxant (Adisa et al, 2019), and sedative, central nervous depressant, and anticonvulsant (Adisa et al, 2019). The usefulness of the plant for medicinal purposes has been attributed to the presence of bioactive compounds (phytochemicals) including alkaloids (Inkoto et al, 2018), anthocyanins (Konaté et al, 2021), flavonoids (Lall et al, 2017), glycosides (Musa et al, 2017; Tamfu et al, 2021), steroids (Konaté et al, 2021), tannins (Musa et al, 2017), and saponins and volatile oils (Ibrahim et al, 2019). The stem extracts of this plant also showed antioxidant and radical scavenging activities (Ahmed et al, 2020).…”

Section: Bioactive Compounds and Potential Health‐promoting Propertie...mentioning

confidence: 99%

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Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Elegbeleye¹,

Krishnamoorthy

Bamidele

et al. 2022

Journal of Food Biochemistry

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The rural communities of the sub‐Sahara regions in Africa are rich in diverse indigenous culinary knowledge and foods, food crops, and condiments such as roots/tubers, cereal, legumes/pulses, locust beans, and green leafy vegetables. These food crops are rich in micronutrients and phytochemicals, which have the potentials to address hidden hunger as well as promote health when consumed. Some examples of these are fermented foods such as ogi and plants such as Vernonia amygdalina (bitter leaf), Zingiber officinales (garlic), Hibiscus sabdariffa (Roselle), and condiments. Food crops from West Africa contain numerous bioactive substances such as saponins, alkaloids, tannins, phenolics, flavonoids, and monoterpenoid chemicals among others. These bioresources have proven biological and pharmacological activities due to diverse mechanisms of action such as immunomodulatory, anti‐inflammatory, antipyretic, and antioxidant activities which made them suitable as candidates for nutraceuticals and pharma foods. This review seeks to explore the different processes such as fermentation applied during food preparation and food crops of West‐African origin with health‐promoting benefits. The different bioactive compounds present in such food or food crops are discussed extensively as well as the diverse application, especially regarding respiratory diseases. Practical applications The plants and herbs summarized here are more easily accessible and affordable by therapists and others having a passion for promising medicinal properties of African‐origin plants.The mechanisms and unique metabolic potentials of African food crops discussed in this article will promote their applicability as a template molecule for novel drug discoveries in treatment strategies for emerging diseases. This compilation of antiviral plants will help clinicians and researchers bring new preventive strategies in combating COVID‐19 like viral diseases, ultimately saving millions of affected people.

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Section: Hibiscetin Kaempferol Luteolinmentioning

confidence: 99%

Section: Hibiscetin Kaempferol Luteolinmentioning

confidence: 99%

Section: Bioactive Compounds and Potential Health‐promoting Propertie...mentioning

confidence: 99%

See 1 more Smart Citation

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Elegbeleye¹,

Krishnamoorthy

Bamidele

et al. 2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

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“…The results (% inhibition) were processed by using Soft-Max Pro software (Molecular Devices, CA, USA) [13]. MTT solution with DMSO (without cells and medium) acted as a blank control in microplate reading while the cyclohexemidine-treated cells served as a drug control [18,19].…”

Section: Identification Of Compoundsmentioning

confidence: 99%

Chemical constituents of Eremomastax speciosa (Hochst.) Cufod leaves and its cytotoxic potential on NIH-3T3 cells

Eve¹,

Alfred²,

Akripo³

et al. 2021

Bull. Chem. Soc. Eth.

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This study aimed at assessing the cytotoxicity of Eremomastax speciosa crude extract on NIH-3T3 fibroblast cell lines and reporting the chemical constituents in the extract. The MTT assay on NIH-3T3 cells showed a significantly lower (p < 0.05) inhibition from E. speciosa (IC50 > 30 µg/mL) compared to cyclohexamide (IC50 > 0.8 µg/mL). This result validates the non-toxicity observed with the use of E. speciosa on normal cells at low to moderate doses. Four compounds were isolated and identified from their EIMS as well as 1D and 2D NMR spectroscopic data namely hydroxyandrographolide (1), stigmasterol glucoside (2), (Z)-4-coumaric acid 4-O-β-D-apiofuranosyl-(1’’→2’)-O-β-D-glucopyranoside (3) and 5-methoxy-4,4′-di-O-methyl- secolariciresinol-9′-monoacetate (4). These compounds are isolated from this species for the first time. Thirteen volatile constituents were detected in the extract using gas chromatography mass spectrometry (GC-MS). Besides 6,10,14-trimethy-2-pentadecanone (12.63%), mostly fatty acid esters were detected in high amounts notably ethyl hexadecanoate (16.00%), ethyl-9,12,15-octadecatrienoate (11.51%) and 9,12-octadecadienoic acid ethyl ester (8.05%). This study revealed many unsaturated fatty acid esters in E. speciosa and is noteworthy that ω-3 and ω-6 fatty acid esters were predominant, hence an added nutritional value to this plant. KEY WORDS: Eremomastax speciosa, Secondary metabolites, NIH-3T3 cytotoxicity, NMR, GC-MS Bull. Chem. Soc. Ethiop. 2020, 34(3), 633-640. DOI: https://dx.doi.org/10.4314/bcse.v34i3.18

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“…Up to now, many Annonaceae species have been studied worldwide in terms of their genetic diversity, chemical composition and biological activity (Costa et al, 2015;Araujo et al, 2017;Tamfu et al, 2019;Bhardwaj et al, 2019). However, in Vietnam, aside from the investigation of species composition, many studies about Annonaceae mainly focused on the chemical composition of essential oils extracted from species of this family (Tran et al, 2013;Do, 2013) while very few studies related to genetic traits have been conducted as far as we know.…”

Section: Introductionmentioning

confidence: 99%

Molecular phylogeny of Annonaceae species from Binh Chau-Phuoc Buu Nature Reserve based on two chloroplast gene regions

Nguyen

Luu

Trịnh

et al. 2022

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In this study, based on molecular biology techniques, the matK and trnL-F regions of ten Annonaceae species grown in Binh Chau-Phuoc Buu Nature Reserve, Vietnam were successfully amplified and sequenced for the first time. Along with other highly homologous DNA sequences from the GenBank database, the molecular phylogeny of ten studied species was also established. By using the alignment tool of NCBI database, the percentage of identity among sequences of studied species was also presented. The study aims to partially contribute to the further understanding of the evolutionary relationships among Annonaceae species.

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Bioactive constituents from seeds of Annona Senegalensis Persoon (Annonaceae)

Cited by 13 publications

References 12 publications

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Chemical constituents of Eremomastax speciosa (Hochst.) Cufod leaves and its cytotoxic potential on NIH-3T3 cells

Molecular phylogeny of Annonaceae species from Binh Chau-Phuoc Buu Nature Reserve based on two chloroplast gene regions

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