Bioactive Cytochalasins from Aspergillus flavipes, an Endophytic Fungus Associated with the Mangrove Plant Acanthus ilicifolius

Abstract

Five new cytochalasins, Z16–Z20 (1–5), and three known ones, 6–8, were isolated from Aspergillus flavipes, an endophytic fungus associated with Acanthus ilicifolius. Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z17 (2) and rosellichalasin (8) showed cytotoxic activities against A‐549 cell lines with IC50 values of 5.6 and 7.9 μM, respectively.

Marine bacterial inhibitors from the sponge-derived fungus Aspergillus sp.

“…This was also consistent with the 14 amu decrease in the molecular weight of 2 compared to austalide O. 6 The structure of 2 was further confirmed by inspection of COSY, HMQC and HMBC spectra ( Table 2) The known compounds (3-5) were identified as 8-O-4-dehydrodiferulic acid, 29,30 cytochalasin Z17 31 and dihydroisoflavipucine, 32 respectively, by comparing their data Acanthus ilicifolius, 31,33 respectively, and of 5 from Phoma sp. isolated from Salsola oppositifolia.…”

Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis

“…They have been found in several fungal genus, such as Ascochyta sp., Aspergillus sp., Phomopsis sp., Turbercularia sp., Xylaria sp., among others. These substances have a wide range of biological activities including inhibition of HIV-1 protease 2, as well as antibiotic and cytotoxic activities [26,27].…”

Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B

“…The only documented indication of production of cytochalasans in Aspergillus subgenus Circumdati section Nigri is aspergillin PZ, for which aspochalasin C or D has been suggested as precursor [11,12]. However in the sister clade Aspergillus subgenus Circumdati section Flavipedes , numerous cytochalasans have been reported [13,14,15,16,17,18,19,20,21,22,23,24,25,26] including aspochalasin A–D [27,28]. Also in another species of Aspergillus subgenus Circumdati section Circumdati , Aspergillus elegans several cytochalasins were found, including aspergillin PZ [29], supporting the view that aspochalasin D is a precursor of aspergillin PZ.…”