Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

Abstract

Featured Application: Bioactive glass proposed in this study demonstrated its possibility as a drug delivery system based on its nanoporous structure and bioactivity for biomedical application.Abstract: Bioactive glass (BG) was made by the sol-gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron microscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion concentrations released after soaking in simulated body fluid (SBF) for 1, 4, and 7 days were measured by inductively coupled plasma mass spectrometry, and the pH value of the SBF was measured after soaking samples to determine the variation in the environment. Brunauer-Emmett-Teller (BET) analysis was performed to further verify the characteristics of mesoporous structures. High performance liquid chromatography was used to evaluate the drug delivery ability of teicoplanin. Results demonstrated that B-doped BG performed significantly better than BG in parameters assessed by the BET analysis. B-doped BG has nanopores and more rough structures, which is advantageous for drug delivery as there are more porous structures available for drug adsorption. Moreover, B-doped BG was shown to be effective for keeping pH values stable and releasing B ions during soaking in SBF. The cumulative release of teicoplanin from BG and B-doped BG reached 20.09% and 3.17% on the first day, respectively. The drug release gradually slowed, reaching 29.43% and 4.83% after 7 days, respectively. The results demonstrate that the proposed bioactive glass has potential as a drug delivery system.

Mesoporous bioactive glasses for regenerative medicine

“…11 , we must indicate that the solid lines signify well-established properties on which there is a broad consensus on the part of the scientific community, whereas the dashed lines correspond to biological effects more recently proposed or with a minor consensus degree. For instance, Li is considered anti-inflammatory and proposed as osteogenic [ 72 ], B is considered angiogenic and proposed as osteogenic [ 73 ], Se, is recently proposed as antiangiogenic and cancer preventive [ 74 ], Ta, which is gaining much recent notoriety as a hemostatic agent [ 75 ], and so on. Likewise, the presence of several lanthanide therapeutic elements investigated to be added to MBGs, such as Ce [ 76 ], Sm [ 77 ], Eu [ 78 ], or Tb [ 79 ], must be highlighted.…”

Biopolymers Hybrid Particles Used in Dentistry

“…Bioactive glass can be doped with boron to increase its bioactivity and give it a more porous structure. It is advantageous for drug delivery given its ability for drug adsorption [ 74 ] (shown in Figure 6 ). Mesoporous silica nanospheres were developed as engineered nanocarriers within a foam matrix for long-term and sequential delivery.…”

“… The microstructures of ( a ) bioactive glass and ( b ) bioactive glass doped with boron [ 74 ]. Adapted with permission from MDPI AG, Copyright (2020).…”

Influence of varying thermal treatment on bioactive material with equal Ca/P ratio: A local drug delivery system for bone regeneration

“…The mesoporous bioactive material can be considered as LDD carrier for osteogenic and antibacterial activities owing to its tailor‐made morphology and physicochemical properties including porosity, surface area, bone bonding ability and biodegradability 20 . Therefore, the enhanced therapeutic activity can be achieved with ionic dissolutions from the customized composition and phase determination 21,22 . Synergistically, the factors such as BGs shape, size, porosity, density, and crystallization were concurrently taken into account for designing eminent drug delivery system 23 …”