2021
DOI: 10.3389/fcell.2021.643781
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Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis

Abstract: Biomaterials are playing an increased role in the regeneration of damaged or absent bone tissue in the context of trauma, non-union, infection or congenital abnormality. Restoration of not only the physical scaffold that bone provides, but also of its homeostatic functions as a calcium store and hematopoietic organ are the gold standards of any regenerative procedure. Bioactive glasses are of interest as they can bond with the host bone and induce further both bone and blood vessel growth. The composition of t… Show more

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Cited by 33 publications
(33 citation statements)
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“…Their findings confirmed that fewer crystals showing the octa-calcium phosphate (OCP) characteristic were formed on the β-TCP surface, while a thick continuous layer of hydroxycarbonate apatite (HCA) crystals was deposited on the surface of silicate substituted HAp materials [ 107 ]. In addition, one of the main reasons for the combination of CaP cements with BG is that ions released from the BG can induce increased angiogenesis and osteogenic differentiation [ 108 , 109 ]. Angiogenesis and osteogenic differentiation ability of BGs also highly depends on the BG composition.…”
Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning
confidence: 99%
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“…Their findings confirmed that fewer crystals showing the octa-calcium phosphate (OCP) characteristic were formed on the β-TCP surface, while a thick continuous layer of hydroxycarbonate apatite (HCA) crystals was deposited on the surface of silicate substituted HAp materials [ 107 ]. In addition, one of the main reasons for the combination of CaP cements with BG is that ions released from the BG can induce increased angiogenesis and osteogenic differentiation [ 108 , 109 ]. Angiogenesis and osteogenic differentiation ability of BGs also highly depends on the BG composition.…”
Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning
confidence: 99%
“…Thus, bioactivity evaluation of injectable BG incorporated CPC is needed to verify the bone-like apatite accumulation on the surface of the composite. The apatite layer precipitation on the surface of both CPC and BG incorporated CPC composites was analyzed by several researchers using SEM and X-ray diffractometry (XRD) [ [108] , [109] , [110] , 112 , 114 , 116 ]. Characteristic XRD reflections of apatite (2θ peaks approximately at 26°, 29° and 32°) appeared with greater intensity for BG added CPC composites, indicating that the bioactivity is improved with BG modification.…”
Section: Bg Modified Injectable Cap Bone Cements (Cpcs)mentioning
confidence: 99%
“…With advancements in sol-gel chemistry, numerous compositions of bioactive glasses containing up to 90 mol.% SiO 2 are now possible [10]. As the side effects of sustained dosage of antibiotics have been highlighted, therapeutic ions are being explored in bone tissue engineering for their osteogenic, angiogenic, and antibacterial capabilities in bone tissue engineering [47][48][49]. Researchers have investigated the use of bioactive glasses as a reservoir of ions, such as Ca, Mg, Cu, Zn, and Ag as well as rare-earth metals for therapeutic ions [50].…”
Section: Bioactive Glass: An Active Bone Regeneration Materialsmentioning
confidence: 99%
“…Surfaces coated with 45S5 Bioglass® stimulate the release of VEGF and bFGF enhancing angiogenesis [268]. Furthermore, in order to provide a structure that resists physiological stresses and also maximize osteogenic and angiogenic properties, the composition of bioactive glasses can be manipulated [269]. Furthermore, bioglasses showed the ability to stimulate fibroblasts to release VEGF, bFGF, epidermal growth factor, collagen I, and fibronectin enhancing angiogenesis [270].…”
Section: Ceramics Composites and Polymers Pro-angiogenic Biomaterialsmentioning
confidence: 99%