Bioactive glass nanofibers for tissue engineering

Penide, J.; Quintero, F.; Val, J. del; Comesaña, R.; Lusquiños, F.; Riveiro, A.; Pou, J.

doi:10.1016/b978-0-08-102814-8.00012-3

Cited by 4 publications

(4 citation statements)

References 75 publications

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“…In this context, ceramic nanofibers, notably those composed of bioactive glass and glass ceramics, present biological and chemical properties as well as the ability to mimic the hierarchical architecture of the ECM, depicting their great potential applications in the regeneration of bone tissue and wound healing [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…In centrifugal jet spinning, the spinning solution is placed in a rotating spinning head that is continuously fed at a certain flow rate, and, when the rotating speed reaches a critical value, the centrifugal force overcomes the surface tension of the spinning solution, resulting in the ejection of the solution [ 43 , 44 , 45 , 46 , 47 ]. The electrospinning (ES) technique is based on the generation of an electrical field between a solution placed in a capillary tube and a metal collector, and, when the electric field reaches a critical value, electrostatic repulsive forces overcome the surface tension of the polymer solution, producing a charged jet that results in the nanofibers’ formation [ 48 , 49 ]; and solution blow spinning (SBS), in turn, consists of a method in which the spinning solution is pumped through a matrix of concentric nozzles, where the solution passes through the inner nozzle and a pressurized air passes through the external nozzle, simultaneously, then, the high-velocity gas stream overcomes the surface tension of the solution, deforming it, and, during its journey to the collector, the nanofibers are produced by solvent evaporation [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

et al. 2022

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Ceramic nanofibers have been shown to be a new horizon of research in the biomedical area, due to their differentiated morphology, nanoroughness, nanotopography, wettability, bioactivity, and chemical functionalization properties. Therefore, considering the impact caused by the use of these nanofibers, and the fact that there are still limited data available in the literature addressing the ceramic nanofiber application in regenerative medicine, this review article aims to gather the state-of-the-art research concerning these materials, for potential use as a biomaterial for wound healing and bone regeneration, and to analyze their characteristics when considering their application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

et al. 2022

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“…Macro devices based on these biomaterials have been studied since the last decade on different surgical and biomedical applications. However, recently, new processes have been explored to produce some nano structures such as mesoporous bioactive glass nanoparticles (MBGN), nanofibers, among others, in order to enhance BGs bioactivity and to expand the applications in the nanomedicine [ 5 , 6 ]. In this context, the combination of MBGN with different biomaterials at the micro and nanoscale is gaining increasing attention for applications ranging from tissue engineering to drug delivery systems [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

et al. 2021

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Bioactive glasses (BGs) are being increasingly considered for biomedical applications. One convenient approach to utilize BGs in tissue engineering and drug delivery involves their combination with organic biomaterials in order to form composites with enhanced biocompatibility and biodegradability. In this work, mesoporous bioactive glass nanoparticles (MBGN) have been merged with polyhydroxyalkanoate microspheres with the purpose to develop drug carriers. The composite carriers (microspheres) were loaded with curcumin as a model drug. The toxicity and delivery rate of composite microspheres were tested in vitro, reaching a curcumin loading efficiency of over 90% and an improving of biocompatibility of different concentrations of MBGN due to its administrations through the composite. The composite microspheres were tested in terms of controlled release, biocompatibility and bioactivity. Our results demonstrate that the composite microspheres can be potentially used in biomedicine due to their dual effects: bioactivity (due to the presence of MBGN) and curcumin release capability.

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“…The mesoporous feature and hierarchically organized nanoporous matrix in BGNF enhance protein absorption and favor cellular adhesion, proliferation, and bioactivity. 61,62 The insertion of BGNF may lead to a more efficient stimulus to cell receptors and, consequently, recruiting BM-hMSCs presents a superior promotion of osteoinduction. 63 Although the SFO-TA-BGNF scaffold did not significantly improve cell adhesion under BASAL conditions, this may be related to the low concentration of released ions from BGNF in 21 days.…”

Section: Nir Laser Triggered Photothermal Conversion Antibacterial Andmentioning

confidence: 99%

Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties

Abie,

Ünlü,

Pinho

et al. 2024

ACS Appl. Mater. Interfaces

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Biomaterial-mediated bone tissue engineering (BTE) offers an alternative, interesting approach for the restoration of damaged bone tissues in postsurgery osteosarcoma treatment. This study focused on synthesizing innovative composite inks, integrating self-assembled silk fibroin (SF), tannic acids (TA), and electrospun bioactive glass nanofibers 70SiO 2 -25CaO-5P 2 O 5 (BGNF). By synergistically combining the unique characteristics of these three components through self-assembly and microextrusion-based threedimensional (3D) printing, our goal was to produce durable and versatile aerogel-based 3D composite scaffolds. These scaffolds were designed to exhibit hierarchical porosity along with antibacterial, antiosteosarcoma, and bone regeneration properties. Taking inspiration from mussel foot protein attachment chemistry involving the coordination of dihydroxyphenylalanine (DOPA) amino acids with ferric ions (Fe 3+ ), we synthesized a tris-complex catecholate-iron self-assembled composite gel. This gel formation occurred through the coordination of oxidized SF (SFO) with TA and polydopamine-modified BGNF (BGNF-PDA). The dynamic nature of the coordination ligand−metal bonds within the selfassembled SFO matrix provided excellent shear-thinning properties, allowing the SFO-TA-BGNF complex gel to be extruded through a nozzle, facilitating 3D printing into scaffolds with outstanding shape fidelity. Moreover, the developed composite aerogels exhibited multifaceted features, including NIR-triggered photothermal antibacterial and in vitro photothermal antiosteosarcoma properties. In vitro studies showcased their excellent biocompatibility and osteogenic features as seeded cells successfully differentiated into osteoblasts, promoting bone regeneration in 21 days. Through comprehensive characterizations and biological validations, our antibacterial scaffold demonstrated promise as an exceptional platform for concurrent bone regeneration and bone cancer therapy, setting the stage for their potential clinical application.

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Bioactive glass nanofibers for tissue engineering

Cited by 4 publications

References 75 publications

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties

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