Bioactive glass S53P4 in frontal sinus obliteration: A long‐term clinical experience

Peltola, Matti; Aitasalo, Kalle; Suonpää, Jouko; Varpula, Matti; Yli‐Urpo, Antti

doi:10.1002/hed.20436

Cited by 93 publications

(71 citation statements)

References 37 publications

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“…Although bioactive glasses have been used for over 15 years with success in oral and maxillo-facial clinical applications (Froum et al, 1998;Peltola et al, 2006), limited benefits have been reported (Turunen et al, 2004;Wang et al, 2005). Recently, due to the growing evidence showing that strontium influences bone cells and bone metabolism in vitro and in vivo (Marie, 2006), melt-derived strontiumdoped bioactive glasses prepared from a base 45S5 bioglass have been developed and implanted in rat tibia bone marrow (Gorustovich et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Bioactive glasses are surface reactive biomaterials that, when in contact with physiological fluids, release soluble ionic products that have been suggested to stimulate in vitro osteogenesis (Xynos et al, 2000;Tsigkou et al, 2009). In addition, in vivo studies have demonstrated beneficial results from their use in various clinical situations (Froum et al, 1998;Anderegg et al, 1999;Froum et al, 2002;Peltola et al, 2006). After implantation, interaction with surrounding tissues results in a time-dependent alteration of the material's surface and the formation of a hydroxyl carbonate apatite layer that is very similar to the mineral phase of bone (Hench and Paschall, 1973).…”

Section: Introductionmentioning

confidence: 99%

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Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells

Isaac

Nohra²,

Lao³

et al. 2011

eCM

165

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There is accumulating evidence that strontium-containing biomaterials have positive effects on bone tissue repair. We investigated the in vitro effect of a new Sr-doped bioactive glass manufactured by the sol-gel method on osteoblast viability and differentiation. Osteoblasts isolated from foetal mouse calvaria were cultured in the presence of bioactive glass particles; particles were undoped (B75) or Sr-doped with 1 wt.% (B75-Sr1) and 5 wt.% (B75-Sr5). Morphological analysis was carried out by contrast-phase microscopy and scanning electron microscopy (SEM). Cell viability was evaluated by the MTS assay at 24 h, 48 h and 72 h. At 24 h, day 6 and day 12, osteoblast differentiation was evaluated by assaying alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion and gene expression of various bone markers, using Real-Time-PCR. Alizarin Red staining and ALP histoenzymatic localisation were performed on day 12. Microscopic observations and MTS showed an absence of cytotoxicity in the three investigated bioactive glasses. B75-Sr5 particles in cell cultures, in comparison with those of B75 and B75-Sr1, resulted in a significant up-regulation of Runx2, Osterix, Dlx5, collagen I, ALP, bone sialoprotein (BSP) and OC mRNA levels on day 12, which was associated with an increase of ALP activity on day 6 and OC secretion on day 12. In conclusion, osteoblast differentiation of foetal mouse calvarial cells was enhanced in the presence of bioactive glass particles containing 5 wt.% strontium. Thus, B75-Sr5 may represent a promising bone-grafting material for bone regeneration procedures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells

Isaac

Nohra²,

Lao³

et al. 2011

eCM

165

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“…BAG S53P4 has been studied clinically in randomised prospective trials in bone tumour [27,28], trauma [29] and spine surgery [30,31]. Due to its antibacterial properties is has also been used in the treatment of severe chronic osteomyelitis, mastoiditis, spine infections and frontal sinus infections [21,[32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Influence of bioactive glass S53P4 granules and putty on osteomyelitis associated bacteria in vitro

Stoor¹,

Frantzén²

2017

Biomedical Glasses

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Bacterial infection of bone tissue and bone marrow, referred to as osteomyelitis, is a challenging clinical problem. In this study we analysed the influence of the granule size of the bone substitute bioactive glass (BAG) S53P4 and the novel putty material containing BAG S53P4 on four clinically important bacteria associated with osteomyelitis; Staphylococcus aureus, methicillin resistant Staphylococuus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa. Reference materials were the frequently used biomaterial in surgical bone grafting procedures; tricalcium phosphate and an inert glass. Powder of BAG S53P4 was used as a positive control. The materials were incubated with bacterial suspension and the viability of the microbes was determined as colony forming units after cultivation on agar plates. All pathogens lost their viability in contact with the BAG S53P4 granules and the powder of the BAG S53P4. The reference materials tricalcium phosphate and the inert glass had no effect on the viability of the bacteria. The BAG S53P4 putty containing 0.5-0.8 mm granules did not show any antibacterial effect on any of the tested bacteria. New putty compositions need to be investigated to obtain antibacterial properties for this novel bone regeneration biomaterial.

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“…Gosain et al (6) presented a safety and efficacy report for bioactive glass for craniomaxillofacial reconstruction and supported the clinical applications of bioactive glasses in this area. Peltola et al (12) have a report on the use of bioactive glass particles to obliterate the frontal sinus in 30 patients over a 10-year period. Although there was some decrease in radiologic density of the obliteration material over time, they reported the material to be well tolerated with no loss of volume.…”

Section: Resultsmentioning

confidence: 99%

Histopathologic Effects of Glass Ionomer Bone Cements Application to Maxillofacial Area: An Experimental Study in Rabbits

Yorgancılar

Firat

Gün

et al. 2012

Biotechnology & Biotechnological Equipment

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Bioactive glass S53P4 in frontal sinus obliteration: A long‐term clinical experience

Abstract: BAG appears to be a reliable frontal sinus obliteration material, providing favorable conditions for total bony sinus obliteration.

Cited by 93 publications

References 37 publications

Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells

Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells

Influence of bioactive glass S53P4 granules and putty on osteomyelitis associated bacteria in vitro

Histopathologic Effects of Glass Ionomer Bone Cements Application to Maxillofacial Area: An Experimental Study in Rabbits

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