Bioactive glasses 2: Composite bone void fillers

Mokhtari, Sahar; Wren, A.W.

doi:10.1016/b978-0-08-100936-9.00018-6

Cited by 5 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The deposition of CaP layer on the surface facilitates the nucleation of biological apatite. This layer then promotes adsorption of proteins, cell attachment and eventually the formation of a strong bond with the hard tissue [28]. SBF trials were conducted on the series of cements and the results are presented and discussed further.…”

Section: Influence Of Strontium On the Physical Mechanical And In-vimentioning

confidence: 99%

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

2019

J. Mod. Mater.

View full text Add to dashboard Cite

In this work, we investigated the effects of strontium incorporation in the glass phase of glass ionomer cements (GIC). Three different glass compositions were synthesized with 0, 5, and 10 mol% of SrO addition. GICs were prepared by the addition of 50 wt% polyacrylic acid (PAA) at powder to liquid ratio of 1:1.5. Initial characterization on the cement series was to study their rheological behavior. Cements represented working times between 50-64 seconds and setting times of 356-452 seconds. Rheological results indicated that the addition of strontium decreases the working and setting times of the cements. To analyze the mechanical properties, compressive and flexural strength studies were performed after 1, 10, and 30 days incubation in simulated body fluid (SBF). The compressive strength of the cements increased as a function of incubation time, with the strontium containing compositions showing the highest strength at 34 megapascal (MPa) and after 30 days of incubation. Biaxial flexural strength of the cements was not significantly affected by the composition and maturation time and ranged between 13.4 to 16.3 MPa. In-vitro bioactivity of the cements was analyzed using SBF trials and after 1, 10, and 30 days incubation periods. Strontium containing cements, showed higher solubility with higher amounts of calcium phosphate surface depositions only after 10 days incubation. The elemental identifications of the surface depositions indicated high amounts of Ca, P and Zn are present on the surface of SBF incubated samples.

show abstract

Section: Influence Of Strontium On the Physical Mechanical And In-vimentioning

confidence: 99%

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

2019

J. Mod. Mater.

View full text Add to dashboard Cite

show abstract

“…1a presents a schematic overview of the bone adhesives used in the vertebral body augmentation. The ultimate goal of using bone adhesive is to obtain optimal functional state of bone tissue by stabilization, surface adhesion, and ultimately the repair of the damaged bone tissue [11,12]. Currently, the clinically available bone adhesives are only based on commercially available materials known as bone cement [7].…”

Section: Introductionmentioning

confidence: 99%

Copper Containing Glass-Based Bone Adhesives for Orthopaedic Applications: Glass Characterization and Advanced Mechanical Evaluation

Mokhtari

Wren

2020

Preprint

View full text Add to dashboard Cite

This study addresses issues with currently used bone adhesives, by producing novel glass based skeletal adhesives through modification of the base glass composition to include copper (Cu) and by characterizing each glass with respect to structural changes. Bioactive glasses have found applications in fields such as orthopedics and dentistry, where they have been utilized for the restoration of bone and teeth. The present work outlines the formation of flexible organic-inorganic polyacrylic acid (PAA) – glass hybrids, commercial forms are known as glass ionomer cements (GICs). Initial stages of this research will involve characterization of the Cu-glasses, significant to evaluate the properties of the resulting adhesives. Scanning electron microscopy (SEM) of annealed Cu glasses indicates the presence of partial crystallization in the glass. The structural analysis of the glass using Raman suggests the formation of CuO nanocrystals on the surface. X-ray diffraction (XRD) pattern and X-ray photoelectron spectroscopy (XPS) further confirmed the formation of crystalline CuO phases on the surface of the annealed Cu-glass. The setting reaction was studied using Fourier transform infrared spectroscopy (ATR-FTIR). The mechanical properties of the Cu containing adhesives exhibited gel viscoelastic behavior and enhanced mechanical properties when compared to the control composition. Compression data indicated the Cu glass adhesives were efficient at energy dissipation due to the reversible interactions between CuO nano particles and PAA polymer chains.

show abstract

“…Over the past few years, bioactive glasses and glass-ceramics have gained increasing attention because of their ability to induce direct bonding to living bone tissue (Baino et al, 2018, Jones, 2013. As many different compositions have been investigated to evaluate such bioactivity, it has been reported that some specialized compositions of bioactive glasses form a bond with soft tissues as well as hard tissues (Mokhtari et al, 2018). Bioactive glass was first discovered by Professor Larry L. Hench.…”

Section: Introductionmentioning

confidence: 99%

Analysis of structure, bioactivity and hardness of titanium incorporated bioactive glass

2019

Biomater Tissue Eng Bull

View full text Add to dashboard Cite

A series of bioactive glass composition were prepared, and the effects of TiO2 addition on the structure, bioactivity and hardness of the glasses were analyzed. This study consisted of glass characterization, simulated body fluid (SBF) trials, and hardness testing. Three glasses were formulated, where a SiO2-CaO-Na2O-P2O5 bioactive glass was used as control, with the addition of 5 and 10 wt.% TiO2 at the expense of CaO. X-ray diffraction patterns confirmed that an amorphous microstructure was obtained for all three glasses. Differential thermal analysis indicated an increase in the glass transition temperature of the glass series from 660°C to 721°C with the incorporation of TiO2. Hot stage microscopy results exhibited higher sintering and softening temperatures for TiO2 containing glasses. Each glass was then incubated in SBF for 1, 10, and 30 days. Scanning electron microscopy images confirmed that the calcium phosphate particulates were precipitated on control glass after 10 days, however, for TiO2 containing glasses, the deposition layer was only observed after 30 days. The hardness of SBF incubated samples were tested, where TiO2 containing glasses showed significantly higher hardness values at each incubation period, with 0.72 GPa for control and 1.71 GPa for the TiO2 containing glass, after 30 days of incubation.

show abstract

Bioactive glasses 2: Composite bone void fillers

Cited by 5 publications

References 54 publications

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

Influence of Strontium on the Physical, Mechanical and In-Vitro Bioactivity of Glass Ionomer Cements

Copper Containing Glass-Based Bone Adhesives for Orthopaedic Applications: Glass Characterization and Advanced Mechanical Evaluation

Analysis of structure, bioactivity and hardness of titanium incorporated bioactive glass

Contact Info

Product

Resources

About