Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications

Mousavi, Seyyed Mojtaba; Hashemi, Seyyed Alireza; Kalashgrani, Masoomeh Yari; Omidifar, Navid; Bahrani, Sonia; Rao, N. Vijayakameswara; Babapoor, Aziz; Gholami, Ahmad; Chiang, Wei‐Hung

doi:10.3390/polym14030617

Cited by 87 publications

(50 citation statements)

References 283 publications

(274 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The dissolution of PVA and PEG increased the number of oxidized chemical bonds such as –COOH on the GO sheets, which affects the size of GO sheets. According to the mentioned above reference, the optical properties of oxidized debris in core-shell fibers are close to GO originated quantum dots, which can be further operated as nanofluorophores for spectroscopic imaging [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…The hydrophilicity of GO is suitable for water-soluble PVA and polyethylene glycol (PEG) to form strong hydrogen bonds within the composite, providing mechanical stability to the core-shell fiber. Additionally, the GO and GO derived nanomaterials have the adjustable fluorescence properties that are applicable for bioimaging of tumor and other biomedical therapies with the encapsulation of drug molecules [ 22 , 23 ]. GO toxicity remains controversial, and working concentration is under investigation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

et al. 2022

View full text Add to dashboard Cite

Electrospinning is a well-established method for the fabrication of polymer biomaterials, including those with core-shell nanofibers. The variability of structures presents a great range of opportunities in tissue engineering and drug delivery by incorporating biologically active molecules such as drugs, proteins, and growth factors and subsequent control of their release into the target microenvironment to achieve therapeutic effect. The object of study is non-woven core-shell PVA–PEG–SiO2@PVA–GO fiber mats assembled by the technology of coaxial electrospinning. The task of the core-shell fiber development was set to regulate the degradation process under external factors. The dual structure was modified with silica nanoparticles and graphene oxide to ensure the fiber integrity and stability. The influence of the nano additives and crosslinking conditions for the composite was investigated as a function of fiber diameter, hydrolysis, and mechanical properties. Tensile mechanical tests and water degradation tests were used to reveal the fracture and dissolution behavior of the fiber mats and bundles. The obtained fibers were visualized by confocal fluorescence microscopy to confirm the continuous core-shell structure and encapsulation feasibility for biologically active components, selectively in the fiber core and shell. The results provide a firm basis to draw the conclusion that electrospun core-shell fiber mats have tremendous potential for biomedical applications as drug carriers, photocatalysts, and wound dressings.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It has been possible to fabricate bioactive carbon dots (CD) with a size of about 4 nm, which have low toxicity, interesting safety responses, and unique photophysical properties. Bioactive CDs were prepared by a novel one-step hydrothermal method from aspirin and adenosine [ 80 , 81 , 82 , 83 ]. Multipurpose CDs are designed and fabricated using a bottom-up synthesis strategy to further manipulate chemical compounds and physical properties by introducing complex bioactive precursors, including nucleic acids, proteins, and small molecules.…”

Section: Graphene Quantum Dotmentioning

confidence: 99%

Recent Advances in Inflammatory Diagnosis with Graphene Quantum Dots Enhanced SERS Detection

et al. 2022

Self Cite

View full text Add to dashboard Cite

Inflammatory diseases are some of the most common diseases in different parts of the world. So far, most attention has been paid to the role of environmental factors in the inflammatory process. The diagnosis of inflammatory changes is an important goal for the timely diagnosis and treatment of various metastatic, autoimmune, and infectious diseases. Graphene quantum dots (GQDs) can be used for the diagnosis of inflammation due to their excellent properties, such as high biocompatibility, low toxicity, high stability, and specific surface area. Additionally, surface-enhanced Raman spectroscopy (SERS) allows the very sensitive structural detection of analytes at low concentrations by amplifying electromagnetic fields generated by the excitation of localized surface plasmons. In recent years, the use of graphene quantum dots amplified by SERS has increased for the diagnosis of inflammation. The known advantages of graphene quantum dots SERS include non-destructive analysis methods, sensitivity and specificity, and the generation of narrow spectral bands characteristic of the molecular components present, which have led to their increased application. In this article, we review recent advances in the diagnosis of inflammation using graphene quantum dots and their improved detection of SERS. In this review study, the graphene quantum dots synthesis method, bioactivation method, inflammatory biomarkers, plasma synthesis of GQDs and SERS GQD are investigated. Finally, the detection mechanisms of SERS and the detection of inflammation are presented.

show abstract

“…These immune-activated smart nanoexosomes may have beneficial effects on plasma in addition to the immunologic antibodies they contain, or they may have inhibitory effects on plasma. Smart nanoexosomes are used to translocate microRNA (miRNA) in viruses to decrease the production of mRNA genes [ 126 , 127 ].…”

Section: Clinical Translation Pathwaymentioning

confidence: 99%

Plasma-Enabled Smart Nanoexosome Platform as Emerging Immunopathogenesis for Clinical Viral Infection

et al. 2022

Self Cite

View full text Add to dashboard Cite

Smart nanoexosomes are nanosized structures enclosed in lipid bilayers that are structurally similar to the viruses released by a variety of cells, including the cells lining the respiratory system. Of particular importance, the interaction between smart nanoexosomes and viruses can be used to develop antiviral drugs and vaccines. It is possible that nanoexosomes will be utilized and antibodies will be acquired more successfully for the transmission of an immune response if reconvalescent plasma (CP) is used instead of reconvalescent plasma exosomes (CPExo) in this concept. Convalescent plasma contains billions of smart nanoexosomes capable of transporting a variety of molecules, including proteins, lipids, RNA and DNA among other viral infections. Smart nanoexosomes are released from virus-infected cells and play an important role in mediating communication between infected and uninfected cells. Infections use the formation, production and release of smart nanoexosomes to enhance the infection, transmission and intercellular diffusion of viruses. Cell-free smart nanoexosomes produced by mesenchymal stem cells (MSCs) could also be used as cell-free therapies in certain cases. Smart nanoexosomes produced by mesenchymal stem cells can also promote mitochondrial function and heal lung injury. They can reduce cytokine storms and restore the suppression of host antiviral defenses weakened by viral infections. This study examines the benefits of smart nanoexosomes and their roles in viral transmission, infection, treatment, drug delivery and clinical applications. We also explore some potential future applications for smart nanoexosomes in the treatment of viral infections.

show abstract

Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications

Cited by 87 publications

References 283 publications

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

Effect of Graphene Oxide and Nanosilica Modifications on Electrospun Core-Shell PVA–PEG–SiO2@PVA–GO Fiber Mats

Recent Advances in Inflammatory Diagnosis with Graphene Quantum Dots Enhanced SERS Detection

Plasma-Enabled Smart Nanoexosome Platform as Emerging Immunopathogenesis for Clinical Viral Infection

Contact Info

Product

Resources

About