BioactiveNeo-Clerodane Diterpenoids TowardTenebrio MolitorLarvae fromTeucrium nudicauleH. andBaccharis spicata(Lam.) Beill

Gallardo, Osvaldo; Tonn, Carlos E.; Nieto, Matı́as; Morales, Glauco; Giordano, Óscar S.

doi:10.1080/10575639608044893

Cited by 17 publications

(6 citation statements)

References 19 publications

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“…Chiari et al 1996). From B. spicata bioactive neo-clerodane diterpenes toward Tenebrio molitor larvae were isolated (Gallardo et al 1996). Phytochemical studies on E. buniifolium showed the presence of flavonoids (Muschietti et al 1994) and ent-Labdanes (Carreras et al 1998).…”

Section: Resultsmentioning

confidence: 99%

In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine

et al. 2005

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Thirty-two organic and aqueous extracts, belonging to 12 Argentine medicinal plants were tested for their in vitro trypanocidal activity on epimastigote forms of Trypanosoma cruzi. Among the selected species, the organic extracts of Ambrosia scabra, Ambrosia tenuifolia, Baccharis spicata, Eupatorium buniifolium, Lippia integrifolia, Mulinum spinosum and Satureja parvifolia, and the aqueous extracts of E. buniifolium, L. integrifolia, M. spinosum and S. parvifolia showed trypanocidal activity with a percentage of growth inhibition higher than 70% at a concentration of 100 microg/ml.

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Section: Resultsmentioning

confidence: 99%

In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine

et al. 2005

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“…T. molitor is not a common pests on J. sambac . However, this model has widely been used in determining the insecticidal effect of triterpenes [ 34 ], diterprenes [ 35 ] and benzoylhydrazine [ 36 ], molting disruption effect of long chain n-alkanes [ 37 ], and the effect of growth development exerted by pyriproxyfen, a juvenile hormone analog in insect [ 38 ]. The use of a similar insect strain generates results that can be compared from various laboratories.…”

Section: Discussionmentioning

confidence: 99%

Molecular diversity and function of jasmintides from Jasminum sambac

et al. 2018

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BackgroundJasmintides jS1 and jS2 from Jasminum sambac were previously identified as a novel family of cysteine-rich peptides (CRPs) with an unusual disulfide connectivity. However, very little else is known about jasmintides, particularly their molecular diversity and functions. Here, we report the discovery and characterization of a novel suite of jasmintides from J. sambac using transcriptomic, peptidomic, structural and functional tools.ResultsTranscriptomic analysis of leaves, flowers and roots revealed 14 unique jasmintide precursors, all of which possess a three-domain architecture comprising a signal peptide, a pro-domain and a mature jasmintide domain. Peptidomic analysis, using fractionated mixtures of jasmintides and chemical derivatization of cysteine to pseudolysine, trypsin digestion and MS/MS sequencing, revealed an additional 86 jasmintides, some of which were post-translationally modified. NMR analysis showed that jasmintide jS3 has three anti-parallel β-strands with a three-disulfide connectivity of CysI−CysV, CysII−CysIV and CysIII−CysVI, which is similar to jasmintide jS1. Jasmintide jS3 was able to withstand thermal, acidic and enzymatic degradation and, importantly, exhibited antifeedant activity against mealworm Tenebrio molitor.ConclusionTogether, this study expands the existing library of jasmintides and furthers our understanding of the molecular diversity and cystine framework of CRPs as scaffolds and tools for engineering peptides targeting pests.Electronic supplementary materialThe online version of this article (10.1186/s12870-018-1361-y) contains supplementary material, which is available to authorized users.

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“…Experiments revealed that when the oxyrane ring was opened as a vecdihydroxy moiety (54) or as a formil group (55) the antifeedant properties disappeared (PFI = 45.0 and 41.0, respectively) (Gallardo et al 1996).…”

Section: Neo-clerodane-diterpenesmentioning

confidence: 99%

Plant secondary metabolites from Argentinean semiarid lands: bioactivity against insects

Sosa

Tonn

2007

Phytochem Rev

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BioactiveNeo-Clerodane Diterpenoids TowardTenebrio MolitorLarvae fromTeucrium nudicauleH. andBaccharis spicata(Lam.) Beill

Cited by 17 publications

References 19 publications

In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine

In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine

Molecular diversity and function of jasmintides from Jasminum sambac

Plant secondary metabolites from Argentinean semiarid lands: bioactivity against insects

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