Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

Nie, Tongtong; Zou, Weijuan; Meng, Zheying; Wang, Longchen; Ying, Tao; Cai, Xiaojun; Wu, Jianrong; Zheng, Yuanyi; Hu, Bing

doi:10.1002/adma.202206286

Cited by 74 publications

(36 citation statements)

References 44 publications

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“…This was attributed to the strong electron synergistic effect of hcp Ir and Ni. [27] A similar tendency was observed in Ni 2p XPS profiles. The binding energies of the peaks of Ni 0 (853.20 eV) and Ni 2+ (856.72 eV) and satellite peak (862.14 eV) in the Ni 2p XPS profile of fcc Ir-Ni were higher than those of the corresponding peaks in the Ni 2p XPS profile of hcp Ir-Ni (Figure 2d).…”

Section: Resultssupporting

confidence: 72%

Homogeneous Metastable Hexagonal Phase Iridium Enhances Hydrogen Evolution Catalysis

Geng

et al. 2023

Advanced Science

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Catalytic reactions are surface-sensitive processes. Fabrication of homogeneous metastable metals can be used to promote phase-dependent catalytic performance; however, this has been a challenging task. Herein, homogeneous metastable hexagonal close-packed (hcp) Ir is epitaxially grown onto metastable phase hcp Ni, as demonstrated using spherical aberration electron microscopy. The as-fabricated metastable hcp Ir exhibits high intrinsic activity for the alkaline hydrogen evolution reaction (HER). In particular, metastable hcp Ir delivers a low overpotential of 17 mV at 10 mA cm −2 and presents a high specific activity of 8.55 mA cm −2 and a high turnover frequency of 38.26 s −1 at −0.07 V versus the reversible hydrogen electrode. Owing to its epitaxially grown structure, metastable hcp Ir is highly stable. Theoretical calculations reveal that metastable hcp Ir promotes H 2 O adsorption and fast H 2 O dissociation, which contributes to its remarkable HER activity. Findings can elucidate the crystal phase-controlled synthesis of advanced noble metal nanomaterials for the fundamental catalytic applications.

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Section: Resultssupporting

confidence: 72%

Homogeneous Metastable Hexagonal Phase Iridium Enhances Hydrogen Evolution Catalysis

Geng

et al. 2023

Advanced Science

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“…For detecting the ROS level, the tumor slices were stained with a DHE (Beyotime, China) probe for 1 h and observed under a fluorescence microscope at an excitation wavelength of 535 nm and an emission wavelength of 610 nm. For evaluating the LPOs, the slices were incubated with a Liperfluo fluorescent probe for 1 h and were then observed by fluorescence microscopy, at an excitation wavelength of 460–550 nm and an emission wavelength of 590 nm …”

Section: Methodsmentioning

confidence: 99%

Arsenic-Loaded Biomimetic Iron Oxide Nanoparticles for Enhanced Ferroptosis-Inducing Therapy of Hepatocellular Carcinoma

Liu

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Hepatocellular carcinoma (HCC) has a poor response to most available systemic therapies due to intrinsic or acquired resistance to apoptosis. Ferroptosis-based therapy is expected to circumvent those limitations. Therefore, the rational design of ferroptosis-based therapies with targeted delivery of ferroptosis inducers for HCC is in need. In this study, we found that arsenic trioxide (ATO) can efficiently induce ferroptosis in HCC cells, and this effect could be reversed by the iron chelator deferoxamine. On this basis, a drug delivery system was constructed to enhance the therapeutic efficacy of ATO by camouflaging ATO-loaded magnetic nanoparticles (Fe 3 O 4 ) with HCC cell membranes, termed AFN@CM. After AFN@CM treatment, glutathione peroxidase 4 was strongly inhibited and intracellular lipid peroxide species were significantly increased in HCC cells. In addition, enhanced ferroptosis and tumor suppression were observed both in vitro and in vivo. The bio-safety of AFN@CM was also demonstrated by the in vivo toxicity evaluation. In addition, benefiting from the cell membrane coating, AFN@CM showed enhanced accumulation at tumor sites and achieved continuous tumor elimination in the mouse model. In conclusion, AFN@CM exhibited satisfactory therapeutic efficacy in the treatment of HCC and provided a desirable ferroptosis-based strategy for safe and reliable HCC therapeutics.

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“…Ferroptosis-induced cell death may overcome chemoresistance and provide alternative therapeutic strategies for leukemia treatment. Ferroptosis has been extensively studied in solid tumors, ,− and ferroptosis-inducing nanoparticles show promising effects in tumor treatment. − The role of ferroptosis has also been indicated in leukemia. , However, efficient ferroptosis-inducing nanoparticles for leukemia treatment are missing. High GSH levels facilitate GPX4 to reduce the peroxidized lipid into nontoxic lipid alcohols in tumor cells and protect them from ferroptosis. , Our data showed that leukemic cells also have high GSH levels, and depletion of cellular GSH levels by the disulfide bonds in cysteine polymers efficiently induces ferroptosis in AML cells.…”

Section: Discussionmentioning

confidence: 99%

A Ferroptosis-Inducing and Leukemic Cell-Targeting Drug Nanocarrier Formed by Redox-Responsive Cysteine Polymer for Acute Myeloid Leukemia Therapy

Meng

et al. 2023

ACS Nano

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Ferroptosis is an alternative strategy to overcome chemoresistance, but effective therapeutic approaches to induce ferroptosis for acute myeloid leukemia (AML) treatment are limited. Here, we developed glutathione (GSH)-responsive cysteine polymer-based ferroptosis-inducing nanomedicine (GCFN) as an efficient ferroptosis inducer and chemotherapeutic drug nanocarrier for AML treatment. GCFN depleted intracellular GSH and inhibited glutathione peroxidase 4, a GSH-dependent hydroperoxidase, to cause lipid peroxidation and ferroptosis in AML cells. Furthermore, GCFN-loaded paclitaxel (PTX@GCFN) targeted AML cells and spared normal hematopoietic cells to limit the myeloablation side effects caused by paclitaxel. PTX@GCFN treatment extended the survival of AML mice by specifically releasing paclitaxel and simultaneously inducing ferroptosis in AML cells with restricted myeloablation and tissue damage side effects. Overall, the dual-functional GCFN acts as an effective ferroptosis inducer and a chemotherapeutic drug carrier for AML treatment.

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Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

Abstract: Figure 1. Schematic diagram of preparation process and therapeutic mechanism of the ferroptosis inducer, HSA-Ce6-IrO 2 (HCIr) nanoclusters.

Cited by 74 publications

References 44 publications

Homogeneous Metastable Hexagonal Phase Iridium Enhances Hydrogen Evolution Catalysis

Homogeneous Metastable Hexagonal Phase Iridium Enhances Hydrogen Evolution Catalysis

Arsenic-Loaded Biomimetic Iron Oxide Nanoparticles for Enhanced Ferroptosis-Inducing Therapy of Hepatocellular Carcinoma

A Ferroptosis-Inducing and Leukemic Cell-Targeting Drug Nanocarrier Formed by Redox-Responsive Cysteine Polymer for Acute Myeloid Leukemia Therapy

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