Bioactive low-shrinkage-stress nanocomposite suppresses S. mutans biofilm and preserves tooth dentin hardness

Bhadila, Ghalia; Filemban, Hanan; Wang, Xiaohong; Melo, Mary Ann S.; Arola, D.; Tay, Franklin R.; Oates, Thomas W.; Weir, Michael D.; Sun, Jirun; Xu, Hockin H.K.

doi:10.1016/j.actbio.2020.07.057

Cited by 39 publications

(28 citation statements)

References 82 publications

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“…The results of the present study evidence that adding DMAHDM in PMMA resin can lead to an increase of compromised bacteria in the saliva-derived biofilms, and the percentage of dead and injured cells increased gradually with the higher mass ratio of DMAHDM in the modified resins. What is more, previous studies demonstrated that by copolymerizing with the resin, the DMAHDM is immobilized in resin and does not leach out over time, thus providing a durable antibacterial capability and mechanical properties [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Autopolymerizing acrylic repair resin containing low concentration of dimethylaminohexadecyl methacrylate to combat saliva-derived bacteria

Zhou

Zhao

et al. 2022

J Mater Sci: Mater Med

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Biofilm accumulation on the polymethyl methacrylate (PMMA) restorations negatively affect the prognosis of the provisional restorations or the following treatment. This study developed a novel antibacterial PMMA resin containing low concentration of dimethylaminohexadecyl methacrylate (DMAHDM). Four resins were tested: (1) PMMA resin (Control), (2) 1.25% DMAHDM, (3) 2.5% DMAHDM, (4) 5% DMAHDM. Adding 1.25% DMAHDM into the PMMA resin did not influence the mechanical properties, degree of conversion, monomer releasing, and color stability of the specimens (p > 0.05). The incorporation of DMAHDM into PMMA resin could greatly prevent saliva-derived biofilms adhesion compared with the control group (p < 0.05). The metabolism level of saliva-derived biofilms on the 1.25%, 2.5%, and 5% DMAHDM resins were reduced by 20%, 54%, and 62%, respectively. And the mechanism of DMAHDM disturbing the integrity of bacterial cell walls was confirmed by flow cytometric analysis. Adding 1.25% and 2.5% DMAHDM did not compromise cytocompatibility of the modified resin (p > 0.05). Therefore, novel PMMA resin containing low concentration DMAHDM is promising as a future antimicrobial provisional restoration material for preventing microbial-induced complications in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Autopolymerizing acrylic repair resin containing low concentration of dimethylaminohexadecyl methacrylate to combat saliva-derived bacteria

Zhou

Zhao

et al. 2022

J Mater Sci: Mater Med

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“…In this study, the assessment of Ca 2+ and PO 4 3– release was quite different from the previous reports, in which the cumulative ion release was measured in a large amount of immersion solution. 16 , 18 Practically, liquid in the mouth remains at a small amount and changes quickly. Therefore, a small volume of solution was applied for just immersing each resin composite and changed every day to better simulate the daily intake of acidic diet in this study.…”

Section: Discussionmentioning

confidence: 99%

“…CaP-containing dental composites have been actively developed and investigated regarding their mechanical properties, 14 , 15 Ca 2+ /PO 4 3– -release capability, 14 , 16 buffering ability, 17 enamel remineralization effect, 16 , 18 antibacterial activity, and so forth. 16 − 18 Among all the reported CaP fillers, nano-CaP particulates have drawn much attention, due to their significant specific surface area (ratio of surface area/volume). For instance, dicalcium phosphate anhydrous (DCPA) and tetracalcium phosphate (TTCP) nanoparticles were synthesized and incorporated into dental resins, respectively.…”

Section: Introductionmentioning

confidence: 99%

Size Dependence of Particulate Calcium Phosphate Fillers in Dental Resin Composites

Huang

Liang

et al. 2021

ACS Omega

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Resin composites that consist of polymeric resins and functional fillers are commonly used as restorative materials for dental caries. Various types of calcium phosphates (CaPs) are studied as remineralizing fillers in the formulation of dental resin composites, which are generally inhibitory to demineralization of teeth, but the performance of resin composites has not yet been investigated comprehensively with respect to the size of CaP particles. In this study, the same tricalcium phosphate (TCP) particles within two different size ranges, the as-received TCP particles (TCP) and those resulted from grinding (TCP-G), were tested to determine the size dependence of CaP fillers in dental resin composites. The buffering capability, mechanical properties, ion release, antibacterial performance, and remineralization effect of TCP/TCP-G-containing composites were experimentally characterized and compared against two other commercial dental materials. The integration of micrometer-sized TCP particles resulted in a similar buffering effect and Ca 2+ /PO 4 3– release behaviors compared to the resin composite containing much smaller TCP-G particles. The flexural strength of the TCP-G resin composite was lower than that of the TCP composite after immersion in water for 30 days. However, the TCP-G composite facilitated crystal deposition toward better gap-closing performance at the dentin–composite interface. This study explored detailed insights about the size effect of CaP fillers, which is useful for the development of functional dental resin composites and their clinical translation.

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“…The researchers developed a hydrolytically stable low-shrinkage-stress polymer containing UDMA and TEG-DVBE (U1V1). It was mixed with dimethylaminododecyl methacrylate monomer (DMAHDM)-with a carbon chain length of 16, which is a highly effective, contact-killing, long-lasting antibacterial material [110][111][112][113][114]. Moreover, adding bioactive nanoparticles of amorphous calcium phosphate (NACP) was advantageous to dental tissues to regenerate the lost minerals and buffer the acidic environment by releasing calcium and phosphate ions to the enamel and dentin under low pH conditions [110][111][112][113][114].…”

Section: Using Hydrolytically Stable Monomers With Antibacterial and ...mentioning

confidence: 99%

Low-Shrinkage Resin Matrices in Restorative Dentistry-Narrative Review

et al. 2022

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Dimethacrylate-based resin composites restorations have become widely-used intraoral materials in daily dental practice. The increasing use of composites has greatly enhanced modern preventive and conservative dentistry. They have many superior features, especially esthetic properties, bondability, and elimination of mercury and galvanic currents. However, polymeric materials are highly susceptible to polymerization shrinkage and stresses that lead to microleakage, biofilm formation, secondary caries, and restoration loss. Several techniques have been investigated to minimize the side effects of these shrinkage stresses. The primary approach is through fabrications and modification of the resin matrices. Therefore, this review article focuses on the methods for testing the shrinkage, as well as formulations of resinous matrices available to reduce polymerization shrinkage and its associated stress. Furthermore, this article reviews recent cutting-edge developments on bioactive low-shrinkage-stress nanocomposites to effectively inhibit the growth and activities of cariogenic pathogens and enhance the remineralization process.

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Bioactive low-shrinkage-stress nanocomposite suppresses S. mutans biofilm and preserves tooth dentin hardness

Cited by 39 publications

References 82 publications

Autopolymerizing acrylic repair resin containing low concentration of dimethylaminohexadecyl methacrylate to combat saliva-derived bacteria

Autopolymerizing acrylic repair resin containing low concentration of dimethylaminohexadecyl methacrylate to combat saliva-derived bacteria

Size Dependence of Particulate Calcium Phosphate Fillers in Dental Resin Composites

Low-Shrinkage Resin Matrices in Restorative Dentistry-Narrative Review

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